Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jeremy D. A. Kitson"'
Publikováno v:
Oligonucleotide-Based Drugs and Therapeutics
The gapmer design strategy, combined with developments in nucleoside chemistry, provided the means to design potent antisense oligonucleotides (ASOs) that bind target sequence with high affinity while retaining the compatibility with RNase H1 enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b834e3075adf4a343314509931ef6ba
https://doi.org/10.1002/9781119070153.ch7
https://doi.org/10.1002/9781119070153.ch7
Autor:
Susan L. Dyos, Emma Hiley, Angela A. Dunne, Mary A. Morse, Fiona Flett, Martin Rüdiger, Edward Hollingsworth, Namir J. Hassan, Martin Hibbs, Jonathan P. Hutchinson, David G. Tew, Amanda Emmons, David J. Powell, Jeremy D. A. Kitson, Sheraz Gul
Publikováno v:
Biochemical Journal. 419:65-73
Identification of small-molecule inhibitors by high-throughput screening necessitates the development of robust, reproducible and cost-effective assays. The assay approach adopted may utilize isolated proteins or whole cells containing the target of
Autor:
Jeremy D. A. Kitson, Kenneth L. Clark, Mark R. Edbrooke, Nigel J. Gooderham, Emma Koppe, William E. Wixted, Gaelle A. Douillard Guilloux, Linda C. Warnock, Joel D. Parry, Aliza Panjwani, Gemma Turner, Piotr J. Kamola, Paul A. Wilson, Klio Maratou, Stephen A. Hughes, Sofie Eriksson, Kitty Moores, Timothy W. Gant
Publikováno v:
Nucleic Acids Research
With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as therapeutic entities. The increase in potency realized by 'third generation chemistries' may, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01232cad7ce261e9e3cf77f33d86c7c2
http://hdl.handle.net/10044/1/26355
http://hdl.handle.net/10044/1/26355
Autor:
Peter J. M. Openshaw, Onn Min Kon, Robert D. Murdoch, Trevor T. Hansel, Andrew J. Tan, Jaideep Dhariwal, Tanushree Tunstall, Grace Francombe, Reema E. Jones, Grant C. Nicholson, Jane Gilbert, Jeremy D. A. Kitson, Ross P. Walton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0135363 (2015)
PLoS ONE, Vol 10, Iss 9, p e0135363 (2015)
BackgroundPractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4. To measure LPS respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce83fe6eb3f3d6379fbb17db380b1ca
http://hdl.handle.net/10044/1/26525
http://hdl.handle.net/10044/1/26525
Autor:
Barbara G. Avitabile, Paul Bamborough, John A. Christopher, Michael J. Wilson, Aurelie C. Champigny, Geoffrey W. Mellor, Ken Grace, Jeremy D. A. Kitson, Nicholas Probst, Clive A. Smith, Champa Patel, Susan L. Dyos, William L. Rumsey, Jeffrey K. Kerns, James V. Morey, Mary A. Morse, Carolyn F. O’Malley, Geoffrey J. Cutler
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
A potent and selective series of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β is described. The most potent compounds are 8h , 8r and 8v , with IKK-β inhibitory potencies of pIC 50 7.0, 6.8 and 6.8, respectively. The series has excell