Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeremy D Weaver"'
Autor:
Niyas Kudukkil Pulloor, Sajith Nair, Kathleen McCaffrey, Aleksandar D Kostic, Pradeep Bist, Jeremy D Weaver, Andrew M Riley, Richa Tyagi, Pradeep D Uchil, John D York, Solomon H Snyder, Adolfo García-Sastre, Barry V L Potter, Rongtuan Lin, Stephen B Shears, Ramnik J Xavier, Manoj N Krishnan
Publikováno v:
PLoS Pathogens, Vol 10, Iss 2, p e1003981 (2014)
The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of
Externí odkaz:
https://doaj.org/article/f96658edd07f4b1fb196fa2464f3ef81
Publikováno v:
mBio, Vol 10, Iss 2, p e02819-18 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)
Proteins comprised of 50 or fewer amino acids have been shown to interact with and modulate the functions of larger proteins in a range of organisms. Despite the possible importance of small proteins, the true prevalence and capabilities of these reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16616c7d612b6f84751d49043f26765d
https://doaj.org/article/2d39ad6e6f3d4715aa21e30a85f59693
https://doaj.org/article/2d39ad6e6f3d4715aa21e30a85f59693
Publikováno v:
Advances in Biological Regulation. 53:19-27
The diphosphoinositol polyphosphates (“inositol pyrophosphates”; PP-InsPs) regulate many cellular processes in eukaryotes, including stress responses, apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, telomere maintenance, insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082e71c45328d347f3a10efede286c63
https://doi.org/10.1016/j.jbior.2012.10.002
https://doi.org/10.1016/j.jbior.2012.10.002
Publikováno v:
Annual Review of Animal Biosciences. 1:283-309
Phytases are phosphohydrolytic enzymes that initiate stepwise removal of phosphate from phytate. Simple-stomached species such as swine, poultry, and fish require extrinsic phytase to digest phytate, the major form of phosphorus in plant-based feeds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dad4955e6917fff234f51c53e179a7c
https://doi.org/10.1146/annurev-animal-031412-103717
https://doi.org/10.1146/annurev-animal-031412-103717
Autor:
Stephen B. Shears, Jeremy D. Weaver
Publikováno v:
The FASEB Journal. 28
Inositol pyrophosphates (PP-InsPs) such as 1-IP7 and IP8 serve as cellular signals that interface nutrient status with cellular growth and energy homeostasis; PP-InsP turnover may impact bioenerget...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cd495c1c4b49be2be5d83c81fffd32
https://doi.org/10.1096/fasebj.28.1_supplement.1013.12
https://doi.org/10.1096/fasebj.28.1_supplement.1013.12
Autor:
Huanchen, Wang, Himali Y, Godage, Andrew M, Riley, Jeremy D, Weaver, Stephen B, Shears, Barry V L, Potter
Publikováno v:
Chemistry & Biology
Summary Diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25f232d6f16e728d1da9b341d684ad4d
https://pubmed.ncbi.nlm.nih.gov/24768307
https://pubmed.ncbi.nlm.nih.gov/24768307
We illuminate the metabolism and the cell-signaling activities of inositol pyrophosphates, by showing that regulation of yeast cyclin-kinase by 1-InsP7 is not conserved for mammalian CDK5, and by kinetically characterizing Ddp1p/DIPP-mediated dephosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd66589071c8e684e694e2a442ab3fe
https://europepmc.org/articles/PMC3873756/
https://europepmc.org/articles/PMC3873756/
Publikováno v:
Bioscience Reports, Vol 33, Iss 2, p e00022 (2013)
ResearcherID
BASE-Bielefeld Academic Search Engine
Bioscience Reports
ResearcherID
BASE-Bielefeld Academic Search Engine
Bioscience Reports
We obtained detailed kinetic characteristics–stoichiometry, reaction rates, substrate affinities and equilibrium conditions–of human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). This enzyme synthesizes ‘high-energy’ PP-InsPs (dipho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8c0f22a5047a57600c91a149992109
http://www.bioscirep.org/bsr/033/e022/bsr033e022.htm
http://www.bioscirep.org/bsr/033/e022/bsr033e022.htm
Publikováno v:
Chemical Communications (Cambridge, England)
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Replacing the diphosphate (PP) motif of 5-PP-InsP5 with an α-phosphonoacetic acid (PA) ester gives 5-PA-InsP5, which is recognised by the catalytic domain of diphosphoinositol pentakisphosphate kinase 2.
We synthesised analogues of diphosphoino
We synthesised analogues of diphosphoino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff16a16ca496e1e8677bfdc0bbce261b
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Stephen B. Shears, Sindura B. Ganapathi, Yixing Zhou, Nikhil A. Gokhale, Huanchen Wang, Jeremy D. Weaver, Angelika Zaremba, Tobias M. H. Schenk
Publikováno v:
Subcellular Biochemistry ISBN: 9789400730144
Ins(1,4,5)P(3) is a classical intracellular messenger: stimulus-dependent changes in its levels elicits biological effects through its release of intracellular Ca(2+) stores. The Ins(1,4,5)P(3) response is "switched off" by its metabolism to a range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc855dc8da50b5a3478730114c86237
https://doi.org/10.1007/978-94-007-3015-1_13
https://doi.org/10.1007/978-94-007-3015-1_13