Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jeremy D Scheff"'
Autor:
Panteleimon D. Mavroudis, Jeremy D. Scheff, John C. Doyle, Yoram Vodovotz, Ioannis P. Androulakis
Publikováno v:
Computation, Vol 7, Iss 1, p 3 (2018)
The dysregulation of inflammation, normally a self-limited response that initiates healing, is a critical component of many diseases. Treatment of inflammatory disease is hampered by an incomplete understanding of the complexities underlying the infl
Externí odkaz:
https://doaj.org/article/8969d5e2cbec4650b09be42dad308288
Autor:
Jeremy D Scheff, Dimitris K. Agrafiotis, Eric Yang, Victor S. Lobanov, Shih C Shen, Michael A Farnum, James Sefton
Publikováno v:
Database: The Journal of Biological Databases and Curation
Clinical trial data are typically collected through multiple systems developed by different vendors using different technologies and data standards. That data need to be integrated, standardized and transformed for a variety of monitoring and reporti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46070d51d633b9ac31fbe38ef5081bbc
https://doi.org/10.1093/database/baz032
https://doi.org/10.1093/database/baz032
Publikováno v:
Biophysical Journal. 109(2):182-193
The heat-shock response is a key factor in diverse stress scenarios, ranging from hyperthermia to protein folding diseases. However, the complex dynamics of this physiological response have eluded mathematical modeling efforts. Although several compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6563adde2d545edbb9df684cdbece965
Publikováno v:
Journal of Theoretical Biology. 338:9-15
The human body can be viewed as a dynamical system, with physiological states such as health and disease broadly representing steady states. From this perspective, and given inter- and intra-individual heterogeneity, an important task is identifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1813a18cf4bd6d4de6bda2186c3ddd7
https://doi.org/10.1016/j.jtbi.2013.08.011
https://doi.org/10.1016/j.jtbi.2013.08.011
Autor:
John Doyle, Ioannis P. Androulakis, Yoram Vodovotz, Jeremy D. Scheff, Panteleimon D. Mavroudis
Publikováno v:
Computation
Volume 7
Issue 1
Computation, Vol 7, Iss 1, p 3 (2018)
Volume 7
Issue 1
Computation, Vol 7, Iss 1, p 3 (2018)
The dysregulation of inflammation, normally a self-limited response that initiates healing, is a critical component of many diseases. Treatment of inflammatory disease is hampered by an incomplete understanding of the complexities underlying the infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1742b22bf21a6234f8450dcba77f87a
https://doi.org/10.3390/computation7010003
https://doi.org/10.3390/computation7010003
Autor:
Panagiota T. Foteinou, Ioannis P. Androulakis, Jeremy D. Scheff, Stephen F. Lowry, Gary An, John Doyle, Yoram Vodovotz, Panteleimon D. Mavroudis, Thomas E. Dick, Steve E. Calvano
Publikováno v:
Journal of Computational Physics. 244:279-289
Inflammation is a critical component in the body's response to injury. A dysregulated inflammatory response, in which either the injury is not repaired or the inflammatory response does not appropriately self-regulate and end, is associated with a wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::926d0eb764c5ada93858346d5efd7f2c
https://doi.org/10.1016/j.jcp.2012.09.024
https://doi.org/10.1016/j.jcp.2012.09.024
Publikováno v:
Systems Pharmacology and Pharmacodynamics ISBN: 9783319445328
In this chapter we explore the characteristics underlying the development of mechanistic-based models of inflammation. The discussion covers the three basic arms of developing mechanistic models. We begin by exploring the likely experimental analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ed6dd40a777c0f25792c8127b9a03a
https://doi.org/10.1007/978-3-319-44534-2_15
https://doi.org/10.1007/978-3-319-44534-2_15
Autor:
Steven E. Calvano, Ioannis P. Androulakis, Jeremy D. Scheff, Stephen F. Lowry, Alyssa K. Kosmides
Publikováno v:
IEEE Transactions on Biomedical Engineering. 58:3504-3507
Glucocorticoids are steroid hormones which, among other functions, exert an antiinflammatory effect. Endogenous glucocorticoids are normally secreted by the adrenal gland in discrete bursts. It is becoming increasingly evident that this pulsatile sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7295b9f25c7ac7963fec923f7e21b224
https://doi.org/10.1109/tbme.2011.2162236
https://doi.org/10.1109/tbme.2011.2162236
Autor:
Richard R. Almon, Ioannis P. Androulakis, William J. Jusko, Jeremy D. Scheff, Debra C. DuBois
Publikováno v:
Pharmaceutical Research. 28:1081-1089
The area under the curve (AUC) is commonly used to assess the extent of exposure of a drug. The same concept can be applied to generally assess pharmacodynamic responses and the deviation of a signal from its baseline value. When the initial conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffda37a7394acf2143bdd40a7daabf76
https://doi.org/10.1007/s11095-010-0363-8
https://doi.org/10.1007/s11095-010-0363-8
Publikováno v:
Journal of Theoretical Biology. 264:1068-1076
A wide variety of modeling techniques have been applied towards understanding inflammation. These models have broad potential applications, from optimizing clinical trials to improving clinical care. Models have been developed to study specific syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75eda17bf3ffc6f232a4ffcbf146ab5
https://doi.org/10.1016/j.jtbi.2010.03.026
https://doi.org/10.1016/j.jtbi.2010.03.026