Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeremy D, Mason"'
Autor:
Angela M. Lam, Ravi R. Dugyala, Muhammed Sheraz, Fei Liu, Emily P. Thi, Ingrid E. Graves, Andrea Cuconati, Holly Micolochick Steuer, Andrzej Ardzinski, Nathan Overholt, Jeremy D. Mason, Dimitar Gotchev, Andrew G. Cole, Troy O. Harasym, Michael J. Sofia
Publikováno v:
Viruses, Vol 16, Iss 3, p 323 (2024)
HBV RNA destabilizers are a class of small-molecule compounds that target the noncanonical poly(A) RNA polymerases PAPD5 and PAPD7, resulting in HBV RNA degradation and the suppression of viral proteins including the hepatitis B surface antigen (HBsA
Externí odkaz:
https://doaj.org/article/0908b4ef0b784f98b382f882d0593288
Publikováno v:
Journal of the American Chemical Society. 143:11019-11025
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic amino acid residue, is presented. A pivotal transformation in the route involves an intramolecular hydrosilylation-oxidation sequence to set the ring-fusion stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccb13267bbda40290edfddfbbb246b3
https://doi.org/10.1021/jacs.1c03529
https://doi.org/10.1021/jacs.1c03529
Autor:
Kelvin J. Y. Wu, Giambattista Testolin, Alexander S. Mankin, Daniel W. Terwilliger, Amarnath Pisipati, Katherine J. Silvestre, Andrew G. Myers, Matthew J. Mitcheltree, Kelly Chatman, Egor A Syroegin, Jeremy D. Mason, Richard Porter Ladley, Aditya R. Pote, Yury S. Polikanov, Dorota Klepacki
Publikováno v:
Nature. 599(7885)
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e9add280ea59a94a0a3ef98030545
https://pubmed.ncbi.nlm.nih.gov/34754106
https://pubmed.ncbi.nlm.nih.gov/34754106
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic amino acid residue, is presented. A pivotal transformation in the route involves an intramolecular hydrosilylation–oxidation sequence to set the ring-fusion ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0a859488c09086326d5abe8603055e
https://doi.org/10.26434/chemrxiv.14333411.v1
https://doi.org/10.26434/chemrxiv.14333411.v1
Autor:
Jeremy D. Mason, Steven M. Weinreb
Publikováno v:
The Journal of Organic Chemistry. 83:5877-5896
A divergent synthetic strategy has been developed for stereoselective total syntheses of alstoscholarisines A-E, monoterpenoid indole alkaloids which are modulators of adult neuronal stem cells. A pivotal step includes an intermolecular Michael addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bdfb11583078060df27409e7126e7e
https://doi.org/10.1021/acs.joc.8b00889
https://doi.org/10.1021/acs.joc.8b00889
Autor:
Jeremy D. Mason, Chad N. Ungarean, Jaimie M. Mong, Benjamin R. Eyer, S. Shaun Murphree, Nicholas S. Duca
Publikováno v:
Synthesis. 49:2177-2181
An antifouling sesquiterpene isolated from Sinularia sp. was synthesized from citronellyl acetate in eight steps and 9% overall yield. The furan moiety was constructed using a multifunctional sulfone reagent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08c4655193e7960a0acc738b473526f5
https://doi.org/10.1055/s-0036-1588711
https://doi.org/10.1055/s-0036-1588711
Autor:
Jeremy D, Mason, Steven M, Weinreb
Publikováno v:
The Alkaloids. Chemistry and biology. 81
The alstoscholarisines are a small family of biologically and structurally interesting polycyclic monoterpenoid indole alkaloids isolated from the leaf extracts of Alstonia scholaris. The alkaloids can be divided into three different subtypes based u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65e38d3bc90eb72e76832f865071a130
https://pubmed.ncbi.nlm.nih.gov/30685049
https://pubmed.ncbi.nlm.nih.gov/30685049
Autor:
Jeremy D. Mason, Steven M. Weinreb
The alstoscholarisines are a small family of biologically and structurally interesting polycyclic monoterpenoid indole alkaloids isolated from the leaf extracts of Alstonia scholaris. The alkaloids can be divided into three different subtypes based u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbc791cbd0d516593b0bf7d726145e89
https://doi.org/10.1016/bs.alkal.2018.09.001
https://doi.org/10.1016/bs.alkal.2018.09.001
Autor:
Jeremy D. Mason, Steven M. Weinreb
Publikováno v:
Angewandte Chemie. 129:16901-16903
Total syntheses of the monoterpenoid indole alkaloids (±)-alstoscholarisine B and C were accomplished starting from a readily available indole-2-acetic ester and an α,β-unsaturated N-sulfonyllactam.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fff1289214ba016b77ae42317e256ec
https://doi.org/10.1002/ange.201710943
https://doi.org/10.1002/ange.201710943
Publikováno v:
Synthetic Communications. 42:1979-1986
Ketones and aldehydes are conveniently and rapidly reduced to the corresponding alcohols in good yields using sodium borohydride under sealed-tube microwave conditions in either 95% ethanol or water. In purely aqueous systems, highly aliphatic substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bdf5bad50669146dce9ccc2c7699499
https://doi.org/10.1080/00397911.2010.551171
https://doi.org/10.1080/00397911.2010.551171