Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jeremy C. Prodger"'
The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, “quats”, from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6d44cf1e14c7492f4fba890efd5892
https://doi.org/10.1016/0040-4039(94)85222-7
https://doi.org/10.1016/0040-4039(94)85222-7
Autor:
Geracimos Rassias, Neil R. Curtis, John M. Northall, Matthew Gray, Neil G. Stevenson, Andrew J. Walker, Jeremy C. Prodger
Publikováno v:
Organic Process Research & Development. 14:92-98
The supply route to GlaxoSmithKline’s 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742ea08d1ff05825c70919217da5f4a2
https://doi.org/10.1021/op900188v
https://doi.org/10.1021/op900188v
Autor:
Jeremy C. Prodger, Alexandra E. Sherlock, Martin P. Green, Matthew D. Selby, Christopher J. Hayes, Alexander J. Blake, Claire Wilson
Publikováno v:
The Journal of Organic Chemistry. 73:2041-2051
An alkylidene carbene 1,5-CH insertion has been used as a key step in an enantioselective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin. An additional noteworthy feature of the synthesis is the use of a novel oxidative deprotection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956d74b8223ecc2bf199b35244af1023
https://doi.org/10.1021/jo7027695
https://doi.org/10.1021/jo7027695
Publikováno v:
Tetrahedron. 63:6216-6231
A 5- exo -dig radical cyclisation of the bromoamide 34 derived from the enantiopure α-ethynyl substituted amino alcohol 31 led to a 2:1 mixture of β-C3 and α-C3 methyl epimers of the pyrrolidinone 35a – 36a in a combined yield of 73%. Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9938b3937998b531a40649e1dca416
https://doi.org/10.1016/j.tet.2007.03.043
https://doi.org/10.1016/j.tet.2007.03.043
Autor:
Rajnikant Patel, Terry W. Packham, Matthew J. Fuchter, Mark B. Schilling, Andrew J. Burton, Matthew D. Walker, Jeremy C. Prodger, Mika Kristian Lindvall, Kevin S. Cardwell
Publikováno v:
Tetrahedron Letters. 44:5653-5656
Unusual regiochemistry is observed in the products arising from the reaction of lithiated 1,2,4-trichlorobenzene with N,N-dimethylformamide and tetraalkyloxamides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96eaac4e69e9e4e2f00ec2795723ad62
https://doi.org/10.1016/s0040-4039(03)01360-1
https://doi.org/10.1016/s0040-4039(03)01360-1
Autor:
Darren J. Dixon, Gilles J.-M. Doisneau, Jeremy C. Prodger, Hitesh J. Sanganee, Stephen G. Davies
Publikováno v:
Tetrahedron: Asymmetry. 13:647-658
The synthesis and utility of the 3,3-dimethyl-5-substituted-2-pyrrolidinone 'Quat' chiral auxiliary in stereoselective enolate reactions of attached N-acyl side chains combined with the mild and non-racemising conditions required for the ultimate rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c5c6b6c714c4eb047d7ff0e79969ce
https://doi.org/10.1016/s0957-4166(02)00166-0
https://doi.org/10.1016/s0957-4166(02)00166-0
Publikováno v:
Tetrahedron Letters. 43:2649-2652
As part of our studies directed towards a total synthesis of lactacystin, we have developed a reliable and environmentally acceptable method to oxidise 2,2,4-trisubstituted 3-pyrrolines to the corresponding 3-pyrrolin-2-ones. Several protocols were e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f62a907cfac9ae8719e0c3b0f21a376
https://doi.org/10.1016/s0040-4039(02)00285-x
https://doi.org/10.1016/s0040-4039(02)00285-x
Publikováno v:
Tetrahedron Letters. 49:6279-6281
A high yielding and selective method for producing methyl 5-amino-2H-1-benzopyran-8-carboxylate derivatives via gold(I)-catalysed intramolecular alkyne hydroarylation has been developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc6e88e13b647ded1c78b1860cdda2
https://doi.org/10.1016/j.tetlet.2008.08.022
https://doi.org/10.1016/j.tetlet.2008.08.022
Publikováno v:
Tetrahedron Letters. 38:7243-7246
The trifuoroethyl ester was studied as a protection group for sulfate monoesters in carbohydrates. The ester was formed from the sulfate by treatment with trifluorodiazoethane and was compatible with other common protecting groups used in carbohydrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d03d400a7971c70290a1daf38a4af15
https://doi.org/10.1016/s0040-4039(97)01681-x
https://doi.org/10.1016/s0040-4039(97)01681-x
Autor:
Victoria Saez, Duncan S. Holmes, Mark J. Bamford, Paul M. Gore, Richard Priest, Jeremy C. Prodger, Michael I. Bird
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:239-244
Two conformationally constrained analogues of sialyl Lewis X have been synthesised in which the GlcNAc residue has been replaced with cyclohexyl and phenyl rings. The cyclohexyl derived compound was equipotent to sLex and sLea in vitro, suggesting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef3b91ca68fa0a0833e10157d260790
https://doi.org/10.1016/0960-894x(96)00008-x
https://doi.org/10.1016/0960-894x(96)00008-x