Zobrazeno 1 - 10
of 608
pro vyhledávání: '"Jeremy C, Smith"'
Autor:
Udyogi N. K. Conthagamage, Rajitha Rajeshwar T, Stijn van der Ham, Nasim Akhtar, Macallister L. Davis, Senuri G. Jayawardana, Lilia Lopez, Hanumantha Rao Vutukuri, Jeremy C. Smith, Micholas Dean Smith, Víctor García-López
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Rotaxanes equipped with actuators hold great potential for developing highly functional molecular machines. Such systems could significantly enhance our ability to study and manipulate biological and artificial membranes. Here, we introduce
Externí odkaz:
https://doaj.org/article/f55b24d22d5649629a7332907601fe00
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 365-376 (2024)
Abstract GPRC6A, a member of the Family C G‐protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L‐amino acids, the osteocalcin (Ocn) peptide and the steroid hor
Externí odkaz:
https://doaj.org/article/6595614307174a96a72a2183c31401dd
Autor:
Mood Mohan, Omar N. Demerdash, Blake A. Simmons, Seema Singh, Michelle K. Kidder, Jeremy C. Smith
Publikováno v:
ACS Omega, Vol 9, Iss 17, Pp 19548-19559 (2024)
Externí odkaz:
https://doaj.org/article/d2438e50ef7d4399b68203b91061cda4
TCR-H: explainable machine learning prediction of T-cell receptor epitope binding on unseen datasets
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Artificial-intelligence and machine-learning (AI/ML) approaches to predicting T-cell receptor (TCR)-epitope specificity achieve high performance metrics on test datasets which include sequences that are also part of the training set but fail to gener
Externí odkaz:
https://doaj.org/article/f54062259f564308852a53b8e5f33930
Autor:
Zhousheng Xiao, Li Cao, Micholas Dean Smith, Hanxuan Li, Wei Li, Jeremy C. Smith, Leigh Darryl Quarles
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood. Here, we used mouse genetics, mechanical loading, and pharmacological approaches to test the possibility that polycyst
Externí odkaz:
https://doaj.org/article/b1342bf5341549638853c605e0999f4a
Autor:
Rupesh Agarwal, Pawat Pattarawat, Michael R. Duff, Hwa-Chain Robert Wang, Jerome Baudry, Jeremy C. Smith
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 867 (2024)
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal. Herein,
Externí odkaz:
https://doaj.org/article/8c72edc793fc47ea81c5a0326e30330a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background In a previous paper, we classified populated HLA class I alleles into supertypes and subtypes based on the similarity of 3D landscape of peptide binding grooves, using newly defined structure distance metric and hierarchical clust
Externí odkaz:
https://doaj.org/article/e4d13c8451d94829a094ab17984ee4ec
Autor:
David M. Rogers, Rupesh Agarwal, Josh V. Vermaas, Micholas Dean Smith, Rajitha T. Rajeshwar, Connor Cooper, Ada Sedova, Swen Boehm, Matthew Baker, Jens Glaser, Jeremy C. Smith
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Measurement(s) equilibrium association constant (KA) Technology Type(s) molecular docking by scoring function Factor Type(s) Chemical formula and connectivity Sample Characteristic - Organism Severe acute respiratory syndrome-related coronavirus Samp
Externí odkaz:
https://doaj.org/article/fa2418daad2b42f89bea3f819d7b07ae
Autor:
Inga V. Leus, Jon W. Weeks, Vincent Bonifay, Yue Shen, Liang Yang, Connor J. Cooper, Dinesh Nath, Adam S. Duerfeldt, Jeremy C. Smith, Jerry M. Parks, Valentin V. Rybenkov, Helen I. Zgurskaya
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Two membrane cell envelopes act as selective permeability barriers in Gram-negative bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are being directed toward understanding how small molecules per
Externí odkaz:
https://doaj.org/article/c8beeb71c6274a14889057ff8ee519e0
Autor:
Barbara A. Bensing, Haley E. Stubbs, Rupesh Agarwal, Izumi Yamakawa, Kelvin Luong, Kemal Solakyildirim, Hai Yu, Azadeh Hadadianpour, Manuel A. Castro, Kevin P. Fialkowski, KeAndreya M. Morrison, Zdzislaw Wawrzak, Xi Chen, Carlito B. Lebrilla, Jerome Baudry, Jeremy C. Smith, Paul M. Sullam, T. M. Iverson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selecti
Externí odkaz:
https://doaj.org/article/b700213795704bd98ce0a30827b2135e