Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeremy Bullough"'
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1681cbb614c99d18db4a719f8206e70
https://doi.org/10.1158/1535-7163.c.6536250
https://doi.org/10.1158/1535-7163.c.6536250
Supplementary Figure Legends from Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figure Legends - PDF file 41K, Legends for supplemental figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06832d9dfe0e27d733354edca60423ca
https://doi.org/10.1158/1535-7163.22499760
https://doi.org/10.1158/1535-7163.22499760
Autor:
Steven B. Kanner, Koc-Kan Ho, Michael V. McCullar, Marc O'Reilly, Kevin Wright, Scott Pearce, Xiao-Hui Liu, Michael Saunders, Yong Xu, Virgil McCarthy, Jihua Liu, David Vollmer, Anna Senina, Bai Luo, Jeremy Bullough, Adrianne Clifford, Rebecca N. Nix, Jason M. Foulks, K. Mark Parnell
Supplementary Figures 1-4 - PDF file 294K, Supplementary Figure 1: PKM2 activation by screening hit XC-409; Supplementary Figure 2: Phosphorylation state of PKM2 at Tyr105 in cancer cell lines; supplementary Figure 3: Viability of a selection of lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a47597581c335365308895b32c34bb
https://doi.org/10.1158/1535-7163.22499757
https://doi.org/10.1158/1535-7163.22499757
Autor:
Xiao-Hui Liu, Hendrickson Thomas, Kevin Wright, Adrianne Clifford, Michael V. McCullar, Rebecca N. Nix, Steven B. Kanner, Michael Saunders, Jeremy Bullough, Jason M. Foulks, Yong Xu, Scott Pearce, K. Mark Parnell, Koc-Kan Ho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:515-519
Activators of the pyruvate kinase M2 (PKM2) are currently attracting significant interest as potential anticancer therapies. They may achieve a novel antiproliferation response in cancer cells through modulation of the classic ‘Warburg effect’ ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a8997aa61a17e2872460ed59236263
https://doi.org/10.1016/j.bmcl.2013.12.028
https://doi.org/10.1016/j.bmcl.2013.12.028
Autor:
Linda L. Kelley, Mariluz P. Mojica Henshaw, Michael E. Hogan, Jeremy Bullough, Jennifer Morgan, Heather M. Martinez, L. Hammond, P. P. J. Dunn
Publikováno v:
Biopreservation and Biobanking. 8:133-138
Two technologies for dry-state, ambient temperature transport of biospecimens were evaluated in this study. Umbilical cord blood (UCB) samples from 4 individuals were transported at ambient temperature using GenPlates, and the DNA recovered was compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efae4221337265f2f650d63994856204
https://doi.org/10.1089/bio.2010.0014
https://doi.org/10.1089/bio.2010.0014
Autor:
Anna Senina, David Vollmer, Xiao-Hui Liu, Kevin Wright, Virgil McCarthy, Scott Pearce, Marc O'Reilly, Jason M. Foulks, K. Mark Parnell, Steven B. Kanner, Jihua Liu, Bai Luo, Jeremy Bullough, Koc-Kan Ho, Adrianne Clifford, Rebecca N. Nix, Michael Saunders, Yong Xu, Michael V. McCullar
Publikováno v:
Molecular cancer therapeutics. 12(8)
Inactivation of the M2 form of pyruvate kinase (PKM2) in cancer cells is associated with increased tumorigenicity. To test the hypothesis that tumor growth may be inhibited through the PKM2 pathway, we generated a series of small-molecule PKM2 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90d2d6c90d134e7e9c28f8e4947900
https://pubmed.ncbi.nlm.nih.gov/23720766
https://pubmed.ncbi.nlm.nih.gov/23720766
Autor:
Matthew Shaffer, Scott Pearce, Kan Ho, Yong Xu, Michael V. McCullar, Virgil McCarthy, David Vollmer, Xiao-Hui Liu, Jeremy Bullough, Adrianne Clifford, Bai Luo, Steven B. Kanner, Michael Saunders, Jihua Liu, Anna Senina, Jason M. Foulks, K. Mark Parnell
Publikováno v:
Molecular Cancer Therapeutics. 10:B143-B143
Tumor cells primarily utilize aerobic glycolysis, rather than oxidative phosphorylation, to metabolize glucose (the Warburg effect). The M2 splice form of pyruvate kinase (PKM2), the enzyme catalyzing the rate-limiting final step of glycolysis, is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0e403b2420f520327f44030c7feca6
https://doi.org/10.1158/1535-7163.targ-11-b143
https://doi.org/10.1158/1535-7163.targ-11-b143
Autor:
S., Adinarayana1, Choudhary, Prakash C.2 prakash.ch81@gmail.com
Publikováno v:
Chemistry & Biology Interface. Mar/Apr2018, Vol. 8 Issue 2, p115-127. 13p.
Publikováno v:
Molecular Ecology; Jul2006, Vol. 15 Issue 8, p2223-2238, 16p
Autor:
Robert Connor
Imagine driving 16,000 miles in 25 days over some of the roughest terrain in the world, at altitudes up to 16,000 feet, where engines and lungs gasp for air. Imagine 500-mile speed trials over rocky mountain tracks, racing against the clock and 95 ot