Výsledky vyhledávání - "Jeremy Andrew Squire"

Akademický článek

Identification of a rare copy number polymorphic gain at 3q12.2 with candidate genes for familial endometriosis

Autor: Flávia Gaona Oliveira, Júlio Cesar Rosa-e-Silva, Alexandra Galvão Gomes, Juliana Dourado Grzesiuk, Thiago Vidotto, Jeremy Andrew Squire, Rodrigo Alexandre Panepucci, Juliana Meola, Lúcia Martelli

Publikováno v: Revista Brasileira de Ginecologia e Obstetrícia, Vol 46 (2024)

Abstract Endometriosis is a complex disease that affects 10-15% of women of reproductive age. Familial studies show that relatives of affected patients have a higher risk of developing the disease, implicating a genetic role for this disorder. Little

Externí odkaz: https://doaj.org/article/c2183d27e75649eaabab77e1ff1cf12d

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Akademický článek

Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review

Autor: Danielle Barbosa Brotto, Ádamo Davi Diógenes Siena, Isabela Ichihara de Barros, Simone da Costa e Silva Carvalho, Bruna Rodrigues Muys, Lucas Goedert, Cibele Cardoso, Jessica Rodrigues Plaça, Anelisa Ramão, Jeremy Andrew Squire, Luiza Ferreira Araujo, Wilson Araújo da Silva

Publikováno v: Tumor Biology, Vol 42 (2020)

Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved i

Externí odkaz: https://doaj.org/article/ed091ebde5264aefb7a51bb29eb25d49

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Akademický článek

Telomere Attrition in Isolated High-Grade Prostatic Intraepithelial Neoplasia and Surrounding Stroma Is Predictive of Prostate Cancer

Autor: Anthony Michael Joshua, Bisera Vukovic, Ilan Braudey, Sundus Hussein, Maria Zielenska, John Srigleyb, Andrew Evans, Jeremy Andrew Squire

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 1, Pp 81-89 (2007)

The causes of early genomic events underlying the development of prostate cancer (CaP) remain unclear. The onset of chromosomal instability is likely to facilitate the formation of crucial genomic aberrations both in the precursor lesion high-grade p

Externí odkaz: https://doaj.org/article/8ab38427015e4d25a85491c9c5158421

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Akademický článek

Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization

Autor: Marcelo Razera Baruffi, Edgard Edward Engel, Jeremy Andrew Squire, Luis Gonzaga Tone, Silvia Regina Rogatto

Publikováno v: Genetics and Molecular Biology, Vol 26, Iss 2, Pp 107-113 (2003)

We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losse

Externí odkaz: https://doaj.org/article/79194d7f97fa45059d5d8b4ae38a082a

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Abstract 6099: Differential gene expression related to TMPRSS2-ERG fusion, CDK12, RB1, TP53, AR and ZEB1 based on transcriptomic analysis of the TCGA PRAD cohort

Autor: William Lautert-Dutra, Camila Morais Melo, Luiz Paulo Chaves, André Luiz Caliari, Francisco Cesar Souza Silva, Jeremy Andrew Squire

Publikováno v: Cancer Research. 82:6099-6099

Prostate Cancer (PCa) is considered an immunologically excluded tumor, unable to generate an effective T-cell response against cancer cells. Inactivating mutations of the PTEN tumor suppressor are one of the most common events in human malignancies t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc280399dbda54a271aabcc6d5eede0
https://doi.org/10.1158/1538-7445.am2022-6099

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Abstract 6098: Analysis of the impact of ZEB1 expression on pathway enrichment and immune cell abundance in prostate cancer

Autor: Luiz Paulo Chaves, André Luiz Caliari, William Lautert-Dutra, Francisco Cesar Souza Silva, Camila Morais Melo, Fabiano Pinto Saggioro, Rodolfo Borges dos Reis, Jeremy Andrew Squire

Publikováno v: Cancer Research. 82:6098-6098

Prostate cancer (PCa) reactivates a latent embryonic program called epithelial-mesenchymal transition during disease progression. The mesenchymal phenotype contributes to invasion, metastasis and therapy response variation. In this study, we characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d175f28f3864ba096122f839537a3b9a
https://doi.org/10.1158/1538-7445.am2022-6098

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Genotype-phenotype correlation in apparently balanced chromosome translocation carriers

Autor: Tatiana Mozer Joaquim

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Translocações aparentemente equilibradas (TAE) envolvem a troca de segmentos entre cromossomos não-homólogos sem que haja perda ou ganho de material genético detectável pelo método do cariótipo. Este tipo de rearranjo geralmente não causa ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e4f486965f555e4df1a625ece5706

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Caracterização estrutural de Dectin-1 humana e análise de interação com seus alvos moleculares β-glucanos e Syk

Autor: Elvira Regina Tamarozzi

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

Dectin-1 humana é um receptor transmembranar expresso na maioria das células que atuam na imunidade inata, apresenta um único C-type lectin-like domain (CTLD) em sua porção extracelular e um único motivo imunorreceptor de ativação baseada em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d727861cd8c9247f9df9e8fb97f03c88
https://doi.org/10.11606/t.17.2020.tde-09042021-094503

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Dual specificity Phosphatase 1 regulates YAP1 phosphorylation in pancreatic ductal adenocarcinoma

Autor: Ilze Mari Olivi Gomes

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

O adenocarcinoma ductal pancreático (ADP) é um tumor agressivo que representa 85% dos casos de câncer na região exócrina do pâncreas. A sobrevida livre de eventos em 5 anos é de aproximadamente 8%, sendo uma consequência do diagnóstico tardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9641bdf92cb051bb0053a31e6c0cdc95

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Expressão de miRNAs como fator de predição de resposta a quimioterapia primária em pacientes com câncer de mama

Autor: Fabiana de Oliveira Buono

Publikováno v: Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP

OBJETIVO: O objetivo deste estudo é identificar miRNAs e seus RNAm-alvos associados à resposta à quimioterapia primária em pacientes com câncer de mama. METODOLOGIA: Foram utilizadas amostras de pacientes com suspeita de diagnóstico de carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267325d096ad227bd5c844cae6d6587c
https://doi.org/10.11606/d.17.2020.tde-05102020-132026

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