Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jeremy Allegood"'
Autor:
Kim H. H. Liss, Muhammad Mousa, Shria Bucha, Andrew Lutkewitte, Jeremy Allegood, L. Ashley Cowart, Brian N. Finck
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common cause for liver transplantation in many parts of the world. Moreover, the prevalence of MASLD not only increases the deman
Externí odkaz:
https://doaj.org/article/5e48b89e7cc74125961d1b3caf57ad4d
Autor:
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101523- (2022)
Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism is unclear. We have previ
Externí odkaz:
https://doaj.org/article/36b4fda04a2243168e4f494f47289685
Autor:
Timothy D. Rohrbach, April E. Boyd, Pamela J. Grizzard, Sarah Spiegel, Jeremy Allegood, Santiago Lima
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 953-967 (2020)
MS-assisted lipidomic tissue analysis is a valuable tool to assess sphingolipid metabolism dysfunction in disease. These analyses can reveal potential pharmacological targets or direct mechanistic studies to better understand the molecular underpinni
Externí odkaz:
https://doaj.org/article/2d2587a90f85415790e84a5fca109808
Autor:
Deanna L. Davis, Usha Mahawar, Victoria S. Pope, Jeremy Allegood, Carmen Sato-Bigbee, Binks W. Wattenberg
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 505-522 (2020)
Myelin is a unique lipid-rich membrane structure that accelerates neurotransmission and supports neuronal function. Sphingolipids are critical myelin components. Yet sphingolipid content and synthesis have not been well characterized in oligodendrocy
Externí odkaz:
https://doaj.org/article/dae4b46939ec4670b6e03c8e2ecab695
Autor:
Ryan S D'Souza, Jun Y Lim, Alper Turgut, Kelly Servage, Junmei Zhang, Kim Orth, Nisha G Sosale, Matthew J Lazzara, Jeremy Allegood, James E Casanova
Publikováno v:
eLife, Vol 9 (2020)
Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration. Many studies have shown that FA disassembly requires Ca2+ influx, however our understanding of this process remains incomplete. Here, we
Externí odkaz:
https://doaj.org/article/ccb351f40ae24823b1c3f79d2970f156
Autor:
Hui Qi, Shrestha Priyadarsini, Sarah E. Nicholas, Akhee Sarker-Nag, Jeremy Allegood, Charles E. Chalfant, Nawajes A. Mandal, Dimitrios Karamichos
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 636-648 (2017)
The pathophysiology of human keratoconus (KC), a bilateral progressive corneal disease leading to protrusion of the cornea, stromal thinning, and scarring, is not well-understood. In this study, we investigated a novel sphingolipid (SPL) signaling pa
Externí odkaz:
https://doaj.org/article/f49e47c6a60f4fdfa022c91ad2ee9d5e
Autor:
Lin Cai, Clement Oyeniran, Debolina D. Biswas, Jeremy Allegood, Sheldon Milstien, Tomasz Kordula, Michael Maceyka, Sarah Spiegel
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1412-1422 (2016)
The bioactive sphingolipid metabolite, ceramide, regulates physiological processes important for inflammation and elevated levels of ceramide have been implicated in IL-1-mediated events. Although much has been learned about ceramide generation by ac
Externí odkaz:
https://doaj.org/article/b5476c5c1ae144bca1ac9d9ca819d272
Autor:
Megan Stiles, Hui Qi, Eleanor Sun, Jeremy Tan, Hunter Porter, Jeremy Allegood, Charles E. Chalfant, Douglas Yasumura, Michael T. Matthes, Matthew M. LaVail, Nawajes A. Mandal
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 5, Pp 818-831 (2016)
Retinal degeneration (RD) affects millions of people and is a major cause of ocular impairment and blindness. With a wide range of mutations and conditions leading to degeneration, targeting downstream processes is necessary for developing effective
Externí odkaz:
https://doaj.org/article/03f2d67dc29e4cf4ad3286ee06bbb9b1
Autor:
Diem-Hang Nguyen-Tran, Nitai C. Hait, Henrik Sperber, Junlin Qi, Karin Fischer, Nick Ieronimakis, Mario Pantoja, Aislinn Hays, Jeremy Allegood, Morayma Reyes, Sarah Spiegel, Hannele Ruohola-Baker
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 1, Pp 41-54 (2014)
Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease. Studies in Drosophila showed that genetic increase of the levels of the bioactive sphingolipid sphingosine-1-phosphate (S1P) or delivery of 2-acetyl-5-tetrahydroxybutyl imidazole (
Externí odkaz:
https://doaj.org/article/8882fdb5b28248409e6f922a2a11cbc5
Autor:
Masayuki Nagahashi, Akimitsu Yamada, Tomoyoshi Aoyagi, Jeremy Allegood, Toshifumi Wakai, Sarah Spiegel, Kazuaki Takabe
Publikováno v:
Heliyon, Vol 2, Iss 12 (2016)
Background: Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator that regulates many physiological and pathological processes. It has been suggested that S1P gradient with high concentrations in the blood and lymphatic fluid and lo
Externí odkaz:
https://doaj.org/article/1b09bdaf467948b3b6fefe6d3cabbc16