Ocean Data Visualization on a Touchtable Demonstrates Group Content Learning, Science Practices Use, and Potential Embodied Cognition

Autor: Annie Luc, Kathryn A. Stofer, Nikita Soni, Alice Darrow, Lisa Anthony, Brittani Kirkland, Peter Chang, Carrie Schuman, Amanda Morales, Hannah Neff, Jeremy Alexandre

Publikováno v: Research in Science Education. 52:445-457

Conceptualizing and understanding global, physical systems like Earth’s ocean is challenging. Data visualizations on touch-based technology allow learners to explore systems and facilitate embodied experiences, promoting deeper understanding. We in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::934bf615ff78aa18794e710e91ec56f7
https://doi.org/10.1007/s11165-020-09951-9

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

Autor: Agnès Hovasse, Manjula Vinod, Jérôme Eeckhoute, Jeremy Alexandre, Alexandre Berthier, Julie Dubois-Chevalier, Fabrice Bray, Maheul Ploton, Xavier Marechal, Bart Staels, Christine Schaeffer-Reiss, Agata Steenackers, Hélène Duez, Philippe Lefebvre, Geoffrey Porez, Sarah Cianférani, Christian Rolando, Nao Yamakawa, Céline Gheeraert, Tony Lefebvre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, Epub ahead of print. ⟨10.1073/pnas.1805397115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (47), pp.11033-11042. ⟨10.1073/pnas.1805397115⟩

Significance Using an interactomic approach, we have identified the nuclear receptor REV-ERBα as a O-GlcNAc transferase (OGT) protein partner. REV-ERBα protects cytoplasmic OGT from proteasomal degradation and facilitates cytosolic and nuclear prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fffa5683cae464f4eb9d55a699cd33
https://www.hal.inserm.fr/inserm-01924835/document

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ

Autor: François F, Firmin, Frederik, Oger, Céline, Gheeraert, Julie, Dubois-Chevalier, Anne-Sophie, Vercoutter-Edouart, Fawaz, Alzaid, Claire, Mazuy, Hélène, Dehondt, Jeremy, Alexandre, Bruno, Derudas, Quentin, Dhalluin, Maheul, Ploton, Alexandre, Berthier, Eloise, Woitrain, Tony, Lefebvre, Nicolas, Venteclef, François, Pattou, Bart, Staels, Jérôme, Eeckhoute, Philippe, Lefebvre

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.14087. ⟨10.1038/s41598-017-14570-y⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports, 2017, 7 (1), pp.14087. ⟨10.1038/s41598-017-14570-y⟩

International audience; Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4ff2a3c1cfd4ab1ca0b30cc307ffff91
https://www.hal.inserm.fr/inserm-02159068

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

Autor: Geoffrey Porez, Fleur Lien, Hélène Dehondt, Alain Van Dorsselaer, Hélène Diemer, Emmanuel Bouchaert, Alexandre Berthier, Alexandre Patrice, Bart Staels, Jelena Kamilic, Céline Gheeraert, Albert K. Groen, Jeremy Alexandre, Anthony Lucas, François Pattou, Maheul Ploton, Janne Prawitt, Philippe Lefebvre, Sophie Colin, Christophe Rachez

Publikováno v: CLIN Journal, 124(3), 1037-1051. AMER SOC CLINICAL INVESTIGATION INC

The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcriptional regulator of bile acid, lipid, and glucose metabolism. FXR is highly expressed in the liver and intestine and controls the synthesis and enterohepatic circulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012406b7728b8ebd10304b7ce0f756e4
https://research.rug.nl/en/publications/592abb8c-8ae2-4660-9128-78a22f82bf23

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients

Autor: Daniel Margerie, Philippe Lefebvre, Violeta Raverdy, Uwe Schwahn, Hartmut Ruetten, Philip Larsen, Alain Duhamel, Julien Labreuche, Dorothée Thuillier, Bruno Derudas, Céline Gheeraert, Hélène Dehondt, Quentin Dhalluin, Jérémy Alexandre, Robert Caiazzo, Pamela Nesslany, Helene Verkindt, François Pattou, Bart Staels

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-10 (2019)

Abstract Background Clinical data identified an association between the use of HMG-CoA reductase inhibitors (statins) and incident diabetes in patients with underlying diabetes risk factors such as obesity, hypertension and dyslipidemia. The molecula

Externí odkaz: https://doaj.org/article/9dfc1476bb6445368598bcee1cad784b