Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Jeremy A. Squire"'
Autor:
Antonia A. Gazola, William Lautert-Dutra, Leticia Frohlich Archangelo, Rodolfo B. dos Reis, Jeremy A. Squire
Publikováno v:
Molecular Cytogenetics, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract In recent years, the expansion of molecularly targeted cancer therapies has significantly advanced precision oncology. Parallel developments in next-generation sequencing (NGS) technologies have also improved precision oncology applications,
Externí odkaz:
https://doaj.org/article/2ad6ed3d1d3b42d0a1ae06eb3f5f9ab4
Autor:
William Lautert-Dutra, Camila M. Melo, Luiz P. Chaves, Cheryl Crozier, Fabiano P. Saggioro, Rodolfo B. dos Reis, Jane Bayani, Sandro L. Bonatto, Jeremy A. Squire
Publikováno v:
Molecular Cytogenetics, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background In prostate cancer (PCa), well-established biomarkers such as MSI status, TMB high, and PDL1 expression serve as reliable indicators for favorable responses to immunotherapy. Recent studies have suggested a potential association b
Externí odkaz:
https://doaj.org/article/506ccc0825c94ba5a2768f71738573d5
Autor:
William Lautert-Dutra, Camila M. Melo, Luiz P. Chaves, Francisco C. Souza, Cheryl Crozier, Adam E. Sundby, Elizabeth Woroszchuk, Fabiano P. Saggioro, Filipe S. Avante, Rodolfo B. dos Reis, Jeremy A. Squire, Jane Bayani
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The diverse clinical outcomes of prostate cancer have led to the development of gene signature assays predicting disease progression. Improved prostate cancer progression biomarkers are needed as current RNA biomarker tests have varying success for i
Externí odkaz:
https://doaj.org/article/a1fb79af93bd4f06adfa1592578150c9
Autor:
Véronique Ouellet, Armen Aprikian, Alain Bergeron, Fadi Brimo, Robert G. Bristow, Simone Chevalier, Darrel Drachenberg, Ladan Fazli, Neil E. Fleshner, Martin Gleave, Pierre Karakiewicz, Laurence Klotz, Louis Lacombe, Jean-Baptiste Lattouf, Theodorus van der Kwast, Jeremy A. Squire, Mathieu Latour, Dominique Trudel, Anne-Marie Mes-Masson, Fred Saad
Publikováno v:
BMC Urology, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Refinement of parameters defining prostate cancer (PC) prognosis are urgently needed to identify patients with indolent versus aggressive disease. The Canadian Prostate Cancer Biomaker Network (CPCBN) consists of researchers from
Externí odkaz:
https://doaj.org/article/925f32af011249508d5bb084d1f7c820
Publikováno v:
Molecular Cytogenetics, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20–30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the PI3K/AKT pathway,
Externí odkaz:
https://doaj.org/article/0b6303a3f776412a80df305ec7fd9c18
Autor:
Muhammad Nawaz, Farah Fatima, Krishna C. Vallabhaneni, Patrice Penfornis, Hadi Valadi, Karin Ekström, Sharad Kholia, Jason D. Whitt, Joseph D. Fernandes, Radhika Pochampally, Jeremy A. Squire, Giovanni Camussi
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair. Hitherto, signifi
Externí odkaz:
https://doaj.org/article/e9e2017e3fdc426f87507d8aaab4a3e6
Autor:
Georges Maire, Maisa Yoshimoto, Susan Chilton-MacNeill, Paul S. Thorner, Maria Zielenska, Jeremy A. Squire
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 3, Pp 260-268 (2009)
Osteosarcoma (OS) is an aggressive bone tumor with complex abnormal karyotypes and a highly unstable genome, exhibiting both numerical- and structural-chromosomal instability (N- and S-CIN). Chromosomal rearrangements and genomic imbalances affecting
Externí odkaz:
https://doaj.org/article/d8888d1e7b044b74829abd70c06f354e
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 10, Pp 1057-1065 (2008)
Sporadic ovarian cancer is a particularly aggressive tumor characterized by highly abnormal karyotypes exhibiting many features of genomic instability. More complex genomic changes in tumors arise as a consequence of chromosomal instability (CIN), wh
Externí odkaz:
https://doaj.org/article/574041fa53fe4704873c865390a06af0
Autor:
Khaldoun Al-Romaih, Bekim Sadikovic, Maisa Yoshimoto, Yuzhuo Wang, Maria Zielenska, Jeremy A. Squire
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 5, Pp 471-480 (2008)
GADD45 genes are epigenetically inactivated in various types of cancer and tumor cell lines. To date, defects of the GADD45 gene family have not been implicated in osteosarcoma (OS) oncogenesis, and the role of this pathway in regulating apoptosis in
Externí odkaz:
https://doaj.org/article/a6e179040aac4e4b90b28ce998efab9c
Autor:
Arezou A. Ghazani, Nona Ameson, Keisha Warrent, Melania Pintilie, Jane Bayani, Jeremy A. Squire, Susan J. Done
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 6, Pp 511-520 (2007)
Synchronous primary breast cancer describes the occurrence of multiple tumors affecting one or both breasts at initial diagnosis. This provides a unique opportunity to identify tissue-specific genomic markers that characterize each tumor while contro
Externí odkaz:
https://doaj.org/article/80a34101950f40c1a312cb3e468cb58e