Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jeremy A. Schofield"'
Autor:
Jeremy A. Schofield, Steven Hahn
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114593- (2024)
Summary: We describe a time-resolved nascent single-cell RNA sequencing (RNA-seq) approach that measures gene-specific transcriptional noise and the fraction of active genes in S. cerevisiae. Most genes are expressed with near-constitutive behavior,
Externí odkaz:
https://doaj.org/article/c6bacd5b8303404393c6b0008d8d2877
Autor:
Jeremy A. Schofield, Steven Hahn
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112387- (2023)
Summary: Three classes of yeast protein-coding genes are distinguished by their dependence on the transcription cofactors TFIID, SAGA, and Mediator (MED) Tail, but whether this dependence is determined by the core promoter, upstream activating sequen
Externí odkaz:
https://doaj.org/article/e3ba0d23183d4e36911ec9a749a5cb75
Autor:
Joshua T. Zimmer, Isaac W. Vock, Jeremy A. Schofield, Lea Kiefer, Michelle H. Moon, Matthew D. Simon
Publikováno v:
bioRxiv
RNA metabolic labeling using 4-thiouridine (s4U) captures the dynamics of RNA synthesis and decay. The power of this approach is dependent on appropriate quantification of labeled and unlabeled sequencing reads, which can be compromised by the appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2418faec35058c4a0a14e8aba3cd019
https://doi.org/10.1101/2023.05.24.542133
https://doi.org/10.1101/2023.05.24.542133
Autor:
Sarah A. Slavoff, Matthew D. Simon, Sowndarya Muthukumar, Alexandra Khitun, Yang Luo, Jeremy A. Schofield, Zhenkun Na, Stephanie Smelyansky, Eugene Valkov
Publikováno v:
Biochemistry
Proteogenomic identification of translated small open reading frames in human has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45248573e9d6416fc7b5fc4f8caaa35d
https://doi.org/10.1021/acs.biochem.0c00672
https://doi.org/10.1021/acs.biochem.0c00672
Publikováno v:
Biochemistry
Decapping is the first committed step in 5'-to-3' RNA decay, and in the cytoplasm of human cells, multiple decapping enzymes regulate the stabilities of distinct subsets of cellular transcripts. However, the complete set of RNAs regulated by any indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c56c22e9b9820d161214604a36d480e
https://doi.org/10.1021/acs.biochem.0c00069
https://doi.org/10.1021/acs.biochem.0c00069
Publikováno v:
Cell Chem Biol
Dcp2 is an important enzyme that controls the stability of a subset of human cellular RNAs encoding functions such as transcription and immune responses. While >1800 Dcp2 substrates have been identified in human cells, compensatory gene expression ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40779dc3acce5014f9c985d0f3a2f151
https://doi.org/10.26434/chemrxiv.12233102
https://doi.org/10.26434/chemrxiv.12233102
Publikováno v:
Journal of the American Chemical Society. 140:14567-14570
RNA-sequencing (RNA-seq) measures RNA abundance in a biological sample but does not provide temporal information about the sequenced RNAs. Metabolic labeling can be used to distinguish newly made RNAs from pre-existing RNAs. Mutations induced from ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dcf7dc90d989cc2c3b9fb39152e0d8
https://doi.org/10.1021/jacs.8b08554
https://doi.org/10.1021/jacs.8b08554
Autor:
Clara Liao, Nima Hooshdaran, Jeremy A. Schofield, Nadya Dimitrova, Jesse R. Zamudio, Christiane E. Olivero, Matthew D. Simon, Jordan Bendor, Elena Martínez-Terroba, Ephrath Tesfaye, Dorthy Fang, Joshua T. Zimmer
Publikováno v:
Mol Cell
Summary The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8390490f90e5bf48b7279fd18b1c6562
https://pubmed.ncbi.nlm.nih.gov/31973890
https://pubmed.ncbi.nlm.nih.gov/31973890
Publikováno v:
Wiley interdisciplinary reviews. RNA. 10(1)
Cellular RNA levels are the result of a juggling act between RNA transcription, processing, and degradation. By tuning one or more of these parameters, cells can rapidly alter the available pool of transcripts in response to stimuli. While RNA sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fce82653ca71ea6b716ccd32fef8a43
https://pubmed.ncbi.nlm.nih.gov/30370679
https://pubmed.ncbi.nlm.nih.gov/30370679
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5173c1c719631d39a2c66b869ef103c0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb23
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb23