Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jeremy A. Pike"'
Autor:
Christopher W. Smith, Zoltan Nagy, Mitchell J. Geer, Jeremy A. Pike, Pushpa Patel, Yotis A. Senis, Alexandra Mazharian
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 6, Pp 102557- (2024)
Background: Inhibition of platelet responsiveness is important for controlling thrombosis. It is well established that platelet endothelial cell adhesion molecule-1 (PECAM-1) serves as a physiological negative regulator of platelet-collagen interacti
Externí odkaz:
https://doaj.org/article/38769b28081b440eaf046853e7c5f3af
Autor:
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor L. J. Tybulewicz, Antal Rot, Anja E. Hauser, Menna R. Clatworthy, Kai-Michael Toellner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to pot
Externí odkaz:
https://doaj.org/article/1cb0d96134a549388a75aab8fcbbbcaf
Autor:
Jeremy A. Pike, Victoria A. Simms, Christopher W. Smith, Neil V. Morgan, Abdullah O. Khan, Natalie S. Poulter, Iain B. Styles, Steven G. Thomas
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 54-58 (2021)
The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segm
Externí odkaz:
https://doaj.org/article/222a62998c644c59bb42c5bc19d835a7
Autor:
Chiara Pallini, Jeremy A. Pike, Christopher O’Shea, Robert K. Andrews, Elizabeth E. Gardiner, Steve P. Watson, Natalie S. Poulter
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 59-73 (2021)
Collagen, the most thrombogenic constituent of blood vessel walls, activates platelets through glycoprotein VI (GPVI). In suspension, following platelet activation by collagen, GPVI is cleaved by A Disintegrin And Metalloproteinase (ADAM)10 and ADAM1
Externí odkaz:
https://doaj.org/article/5e7b1596d96d4c4aadc66a0f0873e18a
Autor:
Abdullah O. Khan, Jeremy A. Pike
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 559-569 (2020)
Recent advances in super-resolution (sub-diffraction limited) microscopy have yielded remarkable insights into the nanoscale architecture and behavior of cells. In addition to the capacity to provide sub 100 nm resolution, these technologies offer un
Externí odkaz:
https://doaj.org/article/a9ad916bdd9a45b7b8501d3f6156706a
Autor:
Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan
Publikováno v:
Haematologica, Vol 107, Iss 1 (2020)
In specialized cells, the expression of specific tubulin isoforms and their subsequent post-translational modifications drive and coordinate unique morphologies and behaviors. The mechanisms by which β1-tubulin, the platelet and megakaryocyte (MK) l
Externí odkaz:
https://doaj.org/article/499818eef52141fda25ba5aa4841cfc0
Autor:
Abdullah O. Khan, Annabel Maclachlan, Gillian C. Lowe, Phillip L.R. Nicolson, Rashid Al Ghaithi, Steven G. Thomas, Steve P. Watson, Jeremy A. Pike, Neil V. Morgan
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/841b56189aed4bee91ddf86401a6496e
Autor:
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Externí odkaz:
https://doaj.org/article/488fe4d4fc05448a940504d50e98e98e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Single molecule imaging approaches like dSTORM and PALM resolve structures at 10–20 nm, and allow for unique insights into protein stoichiometry and spatial relationships. However, key obstacles remain in developing highly accurate quantit
Externí odkaz:
https://doaj.org/article/ffd5b73c61df47d892c81639af4e4a98
Autor:
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes
Publikováno v:
Haematologica, Vol 104, Iss 8 (2019)
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induce
Externí odkaz:
https://doaj.org/article/a5b1b1ff5b2c4c9e817869ca2c198e0a