Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jeremy A. Pike"'
Autor:
Christopher W. Smith, Zoltan Nagy, Mitchell J. Geer, Jeremy A. Pike, Pushpa Patel, Yotis A. Senis, Alexandra Mazharian
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 6, Pp 102557- (2024)
Background: Inhibition of platelet responsiveness is important for controlling thrombosis. It is well established that platelet endothelial cell adhesion molecule-1 (PECAM-1) serves as a physiological negative regulator of platelet-collagen interacti
Externí odkaz:
https://doaj.org/article/38769b28081b440eaf046853e7c5f3af
Autor:
Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, Lingling Zhang, Raul Maqueda Alfaro, Yousuke Takahama, Izumi Ohigashi, Geoffrey Brown, Tomohiro Kurosaki, Victor L. J. Tybulewicz, Antal Rot, Anja E. Hauser, Menna R. Clatworthy, Kai-Michael Toellner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to pot
Externí odkaz:
https://doaj.org/article/1cb0d96134a549388a75aab8fcbbbcaf
Autor:
Zahra Maqsood, Joanne C Clark, Eleyna M Martin, Yam Fung Hilaire Cheung, Luis A Morán, Sean E T Watson, Jeremy A Pike, Ying Di, Natalie S Poulter, Alexandre Slater, Bodo M H Lange, Bernhard Nieswandt, Johannes A Eble, Mike G Tomlinson, Dylan M Owen, David Stegner, Lloyd J Bridge, Christoph Wierling, Steve P Watson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010708 (2022)
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) dom
Externí odkaz:
https://doaj.org/article/4aa0aa11395e4e1d8253e586a4861727
Autor:
Jeremy A. Pike, Victoria A. Simms, Christopher W. Smith, Neil V. Morgan, Abdullah O. Khan, Natalie S. Poulter, Iain B. Styles, Steven G. Thomas
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 54-58 (2021)
The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segm
Externí odkaz:
https://doaj.org/article/222a62998c644c59bb42c5bc19d835a7
Autor:
Chiara Pallini, Jeremy A. Pike, Christopher O’Shea, Robert K. Andrews, Elizabeth E. Gardiner, Steve P. Watson, Natalie S. Poulter
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 59-73 (2021)
Collagen, the most thrombogenic constituent of blood vessel walls, activates platelets through glycoprotein VI (GPVI). In suspension, following platelet activation by collagen, GPVI is cleaved by A Disintegrin And Metalloproteinase (ADAM)10 and ADAM1
Externí odkaz:
https://doaj.org/article/5e7b1596d96d4c4aadc66a0f0873e18a
Autor:
Abdullah O. Khan, Jeremy A. Pike
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 559-569 (2020)
Recent advances in super-resolution (sub-diffraction limited) microscopy have yielded remarkable insights into the nanoscale architecture and behavior of cells. In addition to the capacity to provide sub 100 nm resolution, these technologies offer un
Externí odkaz:
https://doaj.org/article/a9ad916bdd9a45b7b8501d3f6156706a
Autor:
Marie-Blanche Onselaer, Magdolna Nagy, Chiara Pallini, Jeremy A Pike, Gina Perrella, Lourdes Garcia Quintanilla, Johannes A Eble, Natalie S. Poulter, Johan W.M. Heemskerk, Steve P Watson
Publikováno v:
Platelets, Vol 31, Iss 2, Pp 187-197 (2020)
Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind dire
Externí odkaz:
https://doaj.org/article/2e71e59d119541d1ac9e18548a387795
Autor:
Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan
Publikováno v:
Haematologica, Vol 107, Iss 1 (2020)
In specialized cells, the expression of specific tubulin isoforms and their subsequent post-translational modifications drive and coordinate unique morphologies and behaviors. The mechanisms by which β1-tubulin, the platelet and megakaryocyte (MK) l
Externí odkaz:
https://doaj.org/article/499818eef52141fda25ba5aa4841cfc0
Autor:
Daniel J. Nieves, Jeremy A. Pike, Florian Levet, David J. Williamson, Mohammed Baragilly, Sandra Oloketuyi, Ario de Marco, Juliette Griffié, Daniel Sage, Edward A. K. Cohen, Jean-Baptiste Sibarita, Mike Heilemann, Dylan M. Owen
Publikováno v:
Nature Methods. 20:259-267
This analysis compares the performance of seven algorithms for cluster analysis of single-molecule localization microscopy data. The results provide a framework for comparing these types of methods and point users to the best tools.
Single-molec
Single-molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffce103240f0caded806d5e89497481
https://doi.org/10.1038/s41592-022-01750-6
https://doi.org/10.1038/s41592-022-01750-6
Autor:
Abdullah O. Khan, Annabel Maclachlan, Gillian C. Lowe, Phillip L.R. Nicolson, Rashid Al Ghaithi, Steven G. Thomas, Steve P. Watson, Jeremy A. Pike, Neil V. Morgan
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/841b56189aed4bee91ddf86401a6496e