Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jeremy A. O'Sullivan"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed by eosinophils and mast cells that exhibits priming status- and cell type-dependent inhibitory activity. On eosinophils that have been primed with IL-
Externí odkaz:
https://doaj.org/article/5786e146a72f4317828ee7f778030fb2
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020)
Abstract Objective Little has been reported regarding the reliability of methods for the purification of human blood eosinophils. We retrospectively reviewed our experience with 350 consecutive eosinophil isolations. Results Between January 2014 and
Externí odkaz:
https://doaj.org/article/80104cf7b88a4b85853faa747e97f637
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM, respectively) that is selectively expressed on eosinophils, mast cells, and, to
Externí odkaz:
https://doaj.org/article/dacba8be84b643058268c1a96c1faa4b
Autor:
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan
Publikováno v:
Cells, Vol 11, Iss 7, p 1138 (2022)
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. Siglec-6 is
Externí odkaz:
https://doaj.org/article/aa4a409462d94394aa31a086eef4afb4
Autor:
Bradford A. Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C. Brock, Bhupinder Singh, Alan T. Chang, Jeremy A. O’Sullivan, Robert P. Schleimer, Nenad Tomasevic, Christopher R. Bebbington, Bruce S. Bochner
Publikováno v:
Cells, Vol 10, Iss 1, p 19 (2020)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosi
Externí odkaz:
https://doaj.org/article/3a9df22d546640558f4cd6fc839dc654
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
The historical focus on protein–protein interactions in biological systems, at the expense of attention given to interactions between other classes of molecules, has overlooked important and clinically relevant processes and points of potential cli
Externí odkaz:
https://doaj.org/article/f40563cbfc534d8c988b2caf5c676472
Autor:
Frederick J. Kohlhapp, Jeremy A. O’Sullivan, Tamson V. Moore, Andrew Zloza, José A. Guevara-Patiño
Publikováno v:
Mol Immunol
CD8 T cells play a critical role in immunity against intracellular pathogens and cancer. A primary objective of T cell-based vaccine strategies is the induction of durable and effective immune responses. Achieving this goal involves more than simply
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bfda013de95e8285ce0bce7acacad2
https://europepmc.org/articles/PMC9992161/
https://europepmc.org/articles/PMC9992161/
Publikováno v:
Molecular Aspects of Medicine. 90:101104
The term "allergic diseases" encompasses several common, IgE-mediated conditions that range from being annoying to those that are life-threatening. Available treatments include active avoidance of the instigating allergen and the use of a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3923f8337417050959d8b8085e7a35f8
https://doi.org/10.1016/j.mam.2022.101104
https://doi.org/10.1016/j.mam.2022.101104
Autor:
Gunther Marsche, Bruce S. Bochner, Rebecca A. Krier-Burris, Eva Knuplez, Jeremy A. O'Sullivan, Yun Cao
Publikováno v:
Journal of Leukocyte Biology. 108:43-58
Eosinophils are important multifunctional granulocytes. When studying eosinophil function and its contribution to diseases, mouse models are often used. Mouse eosinophils selectively express sialic acid-binding immunoglobulin-like lectin (Siglec)-F.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f127c18c8cebf3c3087811dbac338f8e
https://doi.org/10.1002/jlb.3hi0120-381r
https://doi.org/10.1002/jlb.3hi0120-381r
Publikováno v:
J Leukoc Biol
Mast cells and eosinophils are innate immune cells involved in both acute and chronic inflammatory responses. Siglecs are a family of cell surface receptors that share sialic acid binding activity. Over the past 20 years, our knowledge of the express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d7f94b0479fbd133e42c41e39aea25
https://doi.org/10.1002/jlb.2mr0120-352rr
https://doi.org/10.1002/jlb.2mr0120-352rr