Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jeremy A. Leonard"'
Autor:
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo exposure. When c
Externí odkaz:
https://doaj.org/article/fcd7d8b3f0a74dc38672d8c4d72eb9ac
Autor:
Mario Gaudino, Stephen E. Fremes, N. Bryce Robinson, Katia Audisio, Hillary Lia, Jeremy R. Leonard, Michelle Demetres, Giovanni J. Soletti, Leonard N. Girardi, Mohamed Rahouma
Publikováno v:
J Thorac Cardiovasc Surg
Objective The study objective was to investigate the impact of multiple arterial grafting on long-term all-cause mortality in women undergoing isolated coronary artery bypass grafting. Methods A comprehensive search was performed to identify observat
Autor:
Christopher Lau, Richard B. Devereux, Jonathan W. Weinsaft, Maria Chiara Palumbo, Christine Park, Jiwon Kim, Arindam RoyChoudury, Matthew Wingo, Lisa Q. Rong, Leonard N. Girardi, Katherine A Tak, Jeremy R. Leonard, Mary J. Roman, Alberto Redaelli, Hannah W. Mitlak, Mario Gaudino
Publikováno v:
Eur J Cardiothorac Surg
OBJECTIVES Among patients with ascending thoracic aortic aneurysms, prosthetic graft replacement yields major benefits but risk for recurrent aortic events persists for which mechanism is poorly understood. This pilot study employed cardiac magnetic
Supporting systems science through in silico applications: A focus on informing metabolic mechanisms
Autor:
Jeremy A. Leonard
Publikováno v:
Current Opinion in Toxicology. 16:1-8
Despite the advent of new in silico methodologies to characterize exposure and pharmacokinetic properties of environmental chemicals, numerous limitations remain in the understanding and predicting of metabolic processes. Metabolomics has arisen as m
Autor:
Jeremy A. Leonard, Paul S. Price
Publikováno v:
Curr Opin Toxicol
Currently, there is no single taxonomy for organizing data on the various types of chemical interactions that may affect risks from combined exposures. A taxonomy of chemical interactions is proposed that is based on a combination of the aggregate ex
Autor:
Paolo de Angelis, Jeremy R. Leonard, Matthew Wingo, Leonard N. Girardi, Berhane Worku, Christopher Lau, Mario Gaudino, Faiza M. Khan, Irbaz Hameed
Publikováno v:
Journal of Cardiac Surgery. 34:400-403
Objective Sinus of Valsalva (SOV) aneurysms are rare and data on operative management are limited. They can cause right ventricular outflow tract or pulmonary artery compression, and rupture may be fatal. In this study, we describe our experience wit
Autor:
Monica Munjal, Leonard N. Girardi, Christopher Lau, Giovanni J. Soletti, Mario Gaudino, Ahmed Abouarab, Jeremy R. Leonard, Alexandra N. Schwann
Publikováno v:
The Annals of Thoracic Surgery. 107:1126-1131
Background Cardiac tumors are uncommon, occurring in less than 1% of the population, and are comprised of numerous tumor types. Management of certain tumors types such as sarcoma have evolved and improved in the recent era. We evaluate the outcomes o
Autor:
Irbaz Hameed, Christopher Lau, Berhane Worku, Faiza M. Khan, Antonino Di Franco, Jeremy R. Leonard, Leonard N. Girardi, Arash Salemi, Matthew Wingo, Mario Gaudino, Mohamed Rahouma
Publikováno v:
Journal of Cardiac Surgery. 34:170-180
Background AngioVac is a new device for filtering intravascular thrombi and emboli. Publications on the device are limited and underpowered to objectively estimate its safety and efficacy. We aimed to overcome this by performing a meta-analysis on th
Autor:
Mario Gaudino, Irbaz Hameed, Leonard N. Girardi, Jeremy R. Leonard, T. Sloane Guy, Faiza M. Khan, Matthew Wingo, Matthew Henry, Mohamed Rahouma, Antonino Di Franco
Publikováno v:
International Journal of Cardiology. 278:300-306
Background Minimally invasive mitral valve surgery (MIMVS) is performed with increasing frequency. However, patients undergoing MIMVS might be at increased risk of perioperative stroke, mainly due to retrograde aortic embolization during femoral card
Publikováno v:
Seminars in Thoracic and Cardiovascular Surgery. 31:11-16
Thoracoabdominal aortic aneurysms are most commonly asymptomatic until there is either an impending aortic catastrophe or one that has already occurred. While open surgery remains the gold-standard method for repair, modern technology has led to the