Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jeremy, Travins"'
Autor:
Ross L. Levine, Ari Melnick, Craig B. Thompson, Katharine Yen, Christopher E. Mason, Camelia Gliser, Kim Straley, Jeremy Travins, Jacob Glass, Kristina Knapp, Eytan M. Stein, Abbas Nazir, Andrew M. Intlekofer, Patrick S. Ward, Francine E. Garrett-Bakelman, Kaitlyn Shank, Cem Meydan, Alan H. Shih
Supplementary Figure S1. Response of Tet2-/- Flt3ITD leukemia model to 5-Aza therapy Tet2-/-Flt3ITD leukemia model treated with vehicle or 5-Aza (n=5). Supplementary Figure S2. Idh2R140QFlt3ITD leukemia model phenotype. Supplementary Figure S3. Idh2R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb047766b332d82bdb30da30dd645034
https://doi.org/10.1158/2159-8290.22531861
https://doi.org/10.1158/2159-8290.22531861
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Figure 1. Synthesis and pharmacokinetic characterization of AG-221. Supplementary Figure 2. Biochemical attributes of AG-221. Supplementary Figure 3. Biochemistry of AG-221 with respect to substrate and cofactor. Supplementary Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1
https://doi.org/10.1158/2159-8290.22531945.v1
Autor:
Ross L. Levine, Ari Melnick, Craig B. Thompson, Katharine Yen, Christopher E. Mason, Camelia Gliser, Kim Straley, Jeremy Travins, Jacob Glass, Kristina Knapp, Eytan M. Stein, Abbas Nazir, Andrew M. Intlekofer, Patrick S. Ward, Francine E. Garrett-Bakelman, Kaitlyn Shank, Cem Meydan, Alan H. Shih
Supplementary Methods, Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f50db1655f45b758b8f8601e87f41eb
https://doi.org/10.1158/2159-8290.22531858
https://doi.org/10.1158/2159-8290.22531858
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Table 1. Drug metabolism and pharmacokinetic attributes of AG-221. Supplementary Table 2. Selectivity of AG-221 confirmed by testing against a panel of kinases. Supplementary Table 3. Clinical characteristics of patients with IDH2R140Q-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936
https://doi.org/10.1158/2159-8290.22531936
Autor:
Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939
https://doi.org/10.1158/2159-8290.22531939
Autor:
Ross L. Levine, Ari Melnick, Craig B. Thompson, Katharine Yen, Christopher E. Mason, Camelia Gliser, Kim Straley, Jeremy Travins, Jacob Glass, Kristina Knapp, Eytan M. Stein, Abbas Nazir, Andrew M. Intlekofer, Patrick S. Ward, Francine E. Garrett-Bakelman, Kaitlyn Shank, Cem Meydan, Alan H. Shih
Supplementary Table S1. List of Synergy Genes. Supplementary Table S2. A, Statistical testing of DMCs identified in combination therapy compared to single treatment. B, Differentially methylated CpGs in response to combination therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e36b4e9cb63cb8c9f7235cdc2901b42
https://doi.org/10.1158/2159-8290.22531855
https://doi.org/10.1158/2159-8290.22531855
Autor:
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 574-587 (2016)
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP). Here, we used shRNA screening and identified the metabolic enzyme, met
Externí odkaz:
https://doaj.org/article/bd77de65b22f4da89618bc5269d7f141
Autor:
Joshua Murtie, Anil K. Padyana, Lei Jin, Marc L. Hyer, Zhixiao Liu, Scott A. Biller, Jeremy Travins, Amelia Barnett, Katya Marjon, Brandon Nicolay, Wentao Wei, Raj Nagaraja, Cheng Fang, Yi Gao, Yabo Sun, Ye Zhixiong, Fan Jiang, Peter Kalev, Stefan Gross, Zenon D. Konteatis, Byron DeLaBarre, Zhihua Sui, Kevin Marks, Lenny Dang, Jie Yu, Everton Mandley, Yue Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:4430-4449
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97283e129d6853ac6b9ff735db2724ec
https://doi.org/10.1021/acs.jmedchem.0c01895
https://doi.org/10.1021/acs.jmedchem.0c01895
Autor:
Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik
Publikováno v:
Journal of medicinal chemistry. 65(6)
Inhibition of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd4665a566b3b92c2d5c0229953dea0
https://pubmed.ncbi.nlm.nih.gov/35293760
https://pubmed.ncbi.nlm.nih.gov/35293760
Autor:
Zenon, Konteatis, Jeremy, Travins, Stefan, Gross, Katya, Marjon, Amelia, Barnett, Everton, Mandley, Brandon, Nicolay, Raj, Nagaraja, Yue, Chen, Yabo, Sun, Zhixiao, Liu, Jie, Yu, Zhixiong, Ye, Fan, Jiang, Wentao, Wei, Cheng, Fang, Yi, Gao, Peter, Kalev, Marc L, Hyer, Byron, DeLaBarre, Lei, Jin, Anil K, Padyana, Lenny, Dang, Joshua, Murtie, Scott A, Biller, Zhihua, Sui, Kevin M, Marks
Publikováno v:
Journal of medicinal chemistry. 64(8)
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ec9204e0504cb32589dbe975f9a1cd3
https://pubmed.ncbi.nlm.nih.gov/33829783
https://pubmed.ncbi.nlm.nih.gov/33829783