Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Jeremy, Chataway"'
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 9, Pp 2372-2381 (2024)
Abstract Objectives Hypoperfusion and tissue hypoxia have been implicated as contributory mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to study cortical oxygenation in vivo in patients with MS and age‐matched
Externí odkaz:
https://doaj.org/article/73805677220743bfafcb3ade5d5462dc
Autor:
Alan J Thompson, Charles Wade, Nevin John, Jeremy Chataway, Gavin Giovannoni, Rachael Hunter, Sreedharan Harikrishnan, Floriana De Angelis, Olga Ciccarelli, Eli Silber, John Greenwood, Thomas Williams, Martin Duddy, Basil Sharrack, Annie Hawton, Siddharthan Chandran, Sue Pavitt, Paul Gallagher, Ian Galea, Jennifer M Nicholas, Tarunya Arun, Miriam Mattoscio, Richard Nicholas, Neil Robertson, Carolyn Young, Jeremy Hobart, David Rog, Owen Pearson, Anisha Doshi, Timothy Harrower, Leonora Fisniku, Ruth Geraldes, Nikos Evangelou, Judy Beveridge, Matthew Craner, Don Mahad, Stefano Pluchino, Suresh Chhetri, Susan Tebbs, Marie Braisher, Seema Kalra, Charles Hillier, Chris Frost, Gavin McDonnell, Stuart J Nixon, Helen L Ford, Jeban Ganesalingam, Claire Rice, Alberto Calvi, Cord Spilker, Abdullah Shehu, Martin Lee, James Blackstone, Alessia Bianchi, Agne Straukiene, Gil Barton, Fayyaz Ahmed, Dawn Lyle, Ekaterina Bordea, Sean Apap Mangion, Rachel Merry, Elisabeth Jarman
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Introduction There remains a high unmet need for disease-modifying therapies that can impact disability progression in secondary progressive multiple sclerosis (SPMS). Following positive results of the phase 2 MS-STAT study, the MS-STAT2 phase 3 tria
Externí odkaz:
https://doaj.org/article/69619bde66e34a6986cbeaf0b8bdc802
Autor:
Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Francesco Grussu, Anita Karsa, Becky Samson, Marco Battiston, Claudia A.M. Gandini Wheeler-Kingshott, Karin Shmueli, Olga Ciccarelli, Frederik Barkhof, Jeremy Chataway, Wallace Brownlee, Claudia AM. Gandini Wheeler-Kingshott, Jonathan Stutters, Ferran Prados Carrasco, Marios Yiannakas, Megan Wynne, Marie Braisher, James Blackstone, Leanne Hockey, Josephine Parker, Jennifer Flight, Chris Frost, Jennifer Nicholas, Stuart Nixon, Judy Beveridge
Publikováno v:
Neuroimage: Reports, Vol 4, Iss 3, Pp 100216- (2024)
Background: Deep grey matter pathology is a key driver of disability worsening in people with multiple sclerosis. Quantitative susceptibility mapping (QSM) is an advanced magnetic resonance imaging (MRI) technique which quantifies local magnetic susc
Externí odkaz:
https://doaj.org/article/a5f0c83cc2dc4adf9dbc117e4d8f1ca0
Autor:
Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 2 (2024)
Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated with reduced p
Externí odkaz:
https://doaj.org/article/03779c5cc9264a67966bb74f4a5ef24d
Autor:
Sean Apap Mangion, Jeremy Chataway
Publikováno v:
Advances in Clinical Neuroscience & Rehabilitation, Vol , Iss (2024)
The recent availability of disease modifying treatments (DMTs) for progressive multiple sclerosis (PMS) is a welcome change, yet the limitations of clinical trial design and the real-world makeup of the PMS population necessitate a balanced view of t
Externí odkaz:
https://doaj.org/article/9bbbed9350f844369444f6612631575f
Publikováno v:
Advances in Clinical Neuroscience & Rehabilitation, Vol , Iss (2024)
Comorbid conditions are common in people with multiple sclerosis (MS) and can lead to diagnostic delay and poorer outcomes. Neurologists have an opportunity to identify and address comorbidities within routine care, without major time or resource bur
Externí odkaz:
https://doaj.org/article/36d91468360d4e1d90f234676a4509f6
Autor:
Thomas Williams, Sarah Alexander, James Blackstone, Floriana De Angelis, Nevin John, Anisha Doshi, Judy Beveridge, Marie Braisher, Emma Gray, Jeremy Chataway, on behalf of the MS-SMART and MS-STAT2 Investigators
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Slower than planned recruitment is a major factor contributing to the delay or failure of randomised controlled trials to report on time. There is a limited evidence base regarding the optimisation of recruitment strategies. Here
Externí odkaz:
https://doaj.org/article/c087029f72aa4fbd9f27eeaa9a7a0d7f
Autor:
Jeremy Chataway, Tim Soane, Suvankar Pal, Malcolm Macleod, Jing Liao, Fraser S Brown, Charis Wong, Ankur Singh, Gavin Langlands, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Robert Swingler, Peter Connick, Suzanne Quigley, Peter Foley, Alexandra Thompson, Stella A Glasmacher, D Leighton, Arpan R Mehta, Aimal Ahmad Khan, John Cafferkey, Kieren Egan, Hanna M Vesterinen, Maarij Anwar, Caitlin Beagan, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina Kaddouri, Jamie Kiernan, Jiaming Liu, James Lyon, Alyssa Meng, Vivienne Nguyen, Na Hyun Park, Yousuf Rashid, Andrea Salzinger, Bethany Shiell, Olaf Tomala, Fergal M Waldron, Bhuvaneish T Selvaraj
Publikováno v:
BMJ Open, Vol 13, Iss 2 (2023)
Objectives Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Here, we detail a systematic and s
Externí odkaz:
https://doaj.org/article/8485ba3c3ebb46a882ab95ef3fcbf8c4
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1244 (2023)
Background: We assessed the prevalence and risks associated with pain during and after a multiple sclerosis (MS) relapse, and the impact of pain on quality of life (QoL), in MS patients. Methods: 117 patients suffering an acute MS relapse were evalua
Externí odkaz:
https://doaj.org/article/6a28a13380ad4c999be72b6ae9ea673b
Autor:
Thomas Williams, Amanda Heslegrave, Henrik Zetterberg, Katherine A Miszkiel, Frederik Barkhof, Olga Ciccarelli, Wallace J Brownlee, Jeremy Chataway
Publikováno v:
Brain and Behavior, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background Improved prognostication remains vital in multiple sclerosis to inform personalized treatment approaches. Blood neurofilament light (bNfL) is a promising prognostic biomarker, but to what extent it provides additional information,
Externí odkaz:
https://doaj.org/article/779a3d58730f4a6a8e9bac45c4742f43