Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jeremie Kalfon"'
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David E. Root, James M. McFarland, Rameen Beroukhim, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Reducing disparities is vital for equitable access to precision treatments in cancer. Socioenvironmental factors are a major driver of disparities, but differences in genetic variation likely also contribute. The impact of genetic ancestry o
Externí odkaz:
https://doaj.org/article/f5fc9a4be68842a79c2275a29dc90764
Autor:
Sean Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, Thomas Green, Adam Brown, John Doench, David Root, James McFarland, Rameen Beroukhim, Jesse Boehm
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cancer Pharmacology.
Autor:
Sean A. Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G. Doench, David Root, James McFarland, Rameen Beroukhim, Jesse S. Boehm
Reducing disparities is critical to promote equity of access to precision treatments for all patients with cancer. While socioenvironmental factors are a major driver behind such disparities, biological differences also are likely to contribute. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0df55af9b2b0a3fe1d1e8632f4f48ec
https://doi.org/10.1101/2022.11.18.517155
https://doi.org/10.1101/2022.11.18.517155
Autor:
Taku Harada, Monika Perez, Jeremie Kalfon, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley, Kimberly Stegmaier, Stuart Orkin, Maxim Pimkin
Publikováno v:
Cancer Research. 83:5749-5749
Cell states are established by small sets of lineage-restricted transcription factors (TFs). A generally accepted model posits that core regulatory TFs positively regulate their own and each other’s genes, forming a network of interconnected feed-f
Autor:
Joshua M. Dempster, Guillaume Kugener, Charles Y. Lin, Monika Perez, Neekesh V. Dharia, Jazmin Ewers, Jost Vrabic Koren, Taku Harada, Stuart H. Orkin, Kimberly Stegmaier, Maxim Pimkin, Vikram R Paralkar, Kenneth Eagle, Yaser Heshmati, Jeremie Kalfon
Relapse of acute myeloid leukemia (AML) after allogeneic bone marrow transplantation (alloSCT) has been linked to immune evasion due to reduced expression of major histocompatibility complex class II (MHC-II) proteins through unknown mechanisms. We d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cfdd3eb2f808fc6892f9971a2eafadf
https://doi.org/10.1101/2021.08.23.457351
https://doi.org/10.1101/2021.08.23.457351
Autor:
Jayamanna Wickramasinghe, Kim Stegmaier, Monika Perez, Jeremie Kalfon, Yaser Heshmati, Ferrucio Jx, Joshua M. Dempster, Behnam Nabet, Chengtao Li, Maxim Pimkin, Qian Zhu, Zachary T. Herbert, Guillaume Kugener, Joanna S. Yi, Neekesh V. Dharia, Charles Y. Lin, Andrew V. Kossenkov, Kenneth Eagle, Taku Harada, Jost Vrabic Koren, David M. Weinstock, Stuart H. Orkin, Vikram R Paralkar, Bowker A, Jazmin Ewers, Jana M. Ellegast
SummaryA small set of lineage-restricted transcription factors (TFs), termed core regulatory circuitry (CRC), control cell identity and malignant transformation. Here, we integrated gene dependency, chromatin architecture and TF perturbation datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bc6d35183132d3c11abd6a5a61142d9
https://doi.org/10.1101/2021.08.03.454902
https://doi.org/10.1101/2021.08.03.454902
Abstract 2710: Associations between structural variant signatures and drug sensitivity in cell lines
Autor:
Simona Dalin, Frank Dubois, Shu Zhang, Alexander Crane, Jeremie Kalfon, Javad Noorbakhsh, Rameen Beroukhim
Publikováno v:
Cancer Research. 82:2710-2710
Structural variants (SVs) within the cancer genome reflect defects in DNA damage repair, impact gene regulation, and alter the genomic landscape. SVs impact a larger fraction of the cancer genome than any other genetic aberration, yet their effects o
Autor:
Sean Alexander Misek, Aaron Fultineer, Jeremie Kalfon, Javad Noorbakhsh, Isabella Boyle, Joshua Dempster, Lia Petronio, Katherine Huang, James McFarland, Rameen Beroukhim, Jesse Boehm
Publikováno v:
Cancer Research. 82:2173-2173
Socioeconomic factors and discrimination play major roles in variable cancer treatment outcomes across individuals from different ancestral backgrounds. Tumors from patients of different ancestry groups also have divergent patterns of somatic and ger
Autor:
Radha L. Kalekar, Francisca Vazquez, Jesse S. Boehm, Thomas A. Skipper, Andrew J. Aguirre, Andrew L. Hong, Chen Yuan, Todd R. Golub, Guillaume Kugener, Westley W. Wu, Kimberly Stegmaier, Adam D. Durbin, Nancy Dumont, Michael V. Rothberg, Jasper E. Neggers, David E. Root, Neekesh V. Dharia, Mai Abdusamad, Andrew D. Cherniack, Adhana Asfaw, Brian M. Wolpin, Jeremie Kalfon, Liam F. Spurr, Brenton R. Paolella, Alfredo Gonzalez, William C. Hahn, Aviad Tsherniak, John M. Krill-Burger, Federica Piccioni, Annan Yang, Yvonne Y. Li
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493-(2020)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
SUMMARY Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosoma
Publikováno v:
Journal of the Royal Society Interface
The genetic code is necessarily degenerate with 64 possible nucleotide triplets being translated into 20 amino acids. Eighteen out of the 20 amino acids are encoded by multiple synonymous codons. While synonymous codons are clearly equivalent in term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca15df7501c2b65abd13a891ebb9155
https://kar.kent.ac.uk/70473/9/rsif.2019.0819.pdf
https://kar.kent.ac.uk/70473/9/rsif.2019.0819.pdf