Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jeremie, Boucher"'
Autor:
Ritesh K. Baboota, Rosa Spinelli, Malin C. Erlandsson, Bruna B. Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria I. Bokarewa, Jeremie Boucher, C. Ronald Kahn, Ulf Smith
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101558- (2022)
Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-
Externí odkaz:
https://doaj.org/article/82af05ba8e3a4d02a32750880a3b60a8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The prevalence of obesity and metabolic diseases continues to rise, which has led to an increased interest in studying adipose tissue to elucidate underlying disease mechanisms. The use of genetic mouse models has been critical for understanding the
Externí odkaz:
https://doaj.org/article/1d7dd6c245794c8e9ef4310dbcdad811
Autor:
Laurianne Bonnet, Ida Alexandersson, Ritesh K. Baboota, Tobias Kroon, Jan Oscarsson, Ulf Smith, Jeremie Boucher
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Cellular senescence is a state of irreversible cell cycle arrest and has been shown to play a key role in many diseases, including metabolic diseases. To investigate the potential contribution of hepatocyte cellular senescence to the metabolic derang
Externí odkaz:
https://doaj.org/article/e07ac7d9dbb3475c9b853917c66c53c3
Autor:
Matúš Soták, Meenu Rohini Rajan, Madison Clark, Matthew Harms, Alankrita Rani, Jamie D. Kraft, David Tandio, Tong Shen, Kamil Borkowski, Oliver Fiehn, John W. Newman, Marianne Quiding-Järbrink, Christina Biörserud, Peter Apelgren, Trude Staalesen, Carolina E. Hagberg, Jeremie Boucher, Ville Wallenius, Stephan Lange, Emma Börgeson
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104602- (2022)
Summary: Adipose tissue inflammation drives obesity-related cardiometabolic diseases. Enhancing endogenous resolution mechanisms through administration of lipoxin A4, a specialized pro-resolving lipid mediator, was shown to reduce adipose inflammatio
Externí odkaz:
https://doaj.org/article/c5ff3de8e19d47f9bfddeae805cb559f
Autor:
Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 15-26 (2020)
Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WA
Externí odkaz:
https://doaj.org/article/f9ddf0eaf4ad46ecababbbec31f4fdd4
Autor:
Kristina Wallenius, Tobias Kroon, Therese Hagstedt, Lars Löfgren, Maria Sörhede-Winzell, Jeremie Boucher, Daniel Lindén, Nicholas D. Oakes
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100176- (2022)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to increase ketone bodies in patients with type 2 diabetes; however, the underlying mechanisms have not been fully elucidated. Here we examined the effect of the SGLT2 inhibitor dapagl
Externí odkaz:
https://doaj.org/article/776ec5390e114d3cb999d3075c5b5a12
Publikováno v:
Bio-Protocol, Vol 11, Iss 24 (2021)
Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend
Externí odkaz:
https://doaj.org/article/9ee2dc0f1e3648a28248eb6ee9abbfa1
Autor:
Se-Hyung Park, Robert N. Helsley, Leila Noetzli, Ho-Chou Tu, Kristina Wallenius, Gavin O’Mahony, Jeremie Boucher, Jianming Liu, Samir Softic
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100731- (2021)
Summary: Ketohexokinase (KHK) catalyzes the first step of fructose metabolism. Inhibitors of KHK enzymatic activity are being evaluated in clinical trials for the treatment of non-alcoholic fatty liver disease (NAFLD) and diabetes. Here, we present a
Externí odkaz:
https://doaj.org/article/8ad1dc90a7ee458c9814f80a26cdf195
Autor:
Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247300 (2021)
ObjectiveGremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 dia
Externí odkaz:
https://doaj.org/article/56874d5e62914cb6835372b1a006b4c0
Autor:
Tobias Kroon, Matthew Harms, Stefanie Maurer, Laurianne Bonnet, Ida Alexandersson, Anna Lindblom, Andrea Ahnmark, Daniel Nilsson, Peter Gennemark, Gavin O'Mahony, Victoria Osinski, Coleen McNamara, Jeremie Boucher
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: Peroxisome proliferator-activated receptors (PPARs) are key transcription factors that regulate adipose development and function, and the conversion of white into brown-like adipocytes. Here we investigated whether PPARα and PPARγ activa
Externí odkaz:
https://doaj.org/article/c8f7d5b18d4a454e9d17350c34792a8f