11p13 microduplication: a differential diagnosis of Silver–Russell syndrome?

Autor: Asmaa K. Amin, Jeremias Krause, Thomas Eggermann

Publikováno v: Molecular Cytogenetics, Vol 17, Iss 1, Pp 1-5 (2024)

Abstract Background Silver–Russel syndrome (SRS) is a congenital disorder which is mainly characterized by intrauterine and postnatal growth retardation, relative macrocephaly, and characteristic (facial) dysmorphisms. The majority of patients show

Externí odkaz: https://doaj.org/article/153e4c9ef32146559747e1e862ef44c1

An Introduction to Deep Learning in Pathology

Autor: Jeremias Krause, Heike I. Grabsch, Jakob Nikolas Kather

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e7a02b7b2922974a4e9fff0017da104
https://doi.org/10.1142/9781800611399_0007

[Artificial intelligence in gastroenterology]

Autor: Jakob Nikolas, Kather, Jeremias, Krause, Tom, Luedde

Publikováno v: Deutsche medizinische Wochenschrift (1946). 145(20)

Artificial intelligence (AI) is currently transforming all aspects of our daily life, including the practice of medicine. Artificial neural networks are a key method of AI. They can very effectively detect subtle patterns in imaging data and speech o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50f364ad4ffd6fb0f93370165382c022
https://pubmed.ncbi.nlm.nih.gov/33022724

Pan-cancer image-based detection of clinically actionable genetic alterations

Autor: Peter Boor, Chiara Loeffler, Akash Patnaik, Heike I. Grabsch, Jefree J. Schulte, Piet A. van den Brandt, Kai A. J. Sommer, Alexander T. Pearson, Loes F. S. Kooreman, Lara R. Heij, Jakob Nikolas Kather, Amelie Echle, Nadina Ortiz-Brüchle, Jan M. Niehues, Andrew Srisuwananukorn, Hermann Brenner, Nicole A. Cipriani, Andrew M. Hanby, Peter Bankhead, Hannah Sophie Muti, Sara Kochanny, Valerie Speirs, Roman D. Buelow, Jeremias Krause, Michael Hoffmeister, Tom Luedde, Dirk Jäger, Christian Trautwein

Publikováno v: Nature Cancer, 1(8), 789-799. Nature Publishing Group
Nat Cancer
Nature Cancer
Kather, J N, Heij, L R, Grabsch, H, Loeffler, C, Echle, A, Muti, H S, Krause, J, Niehues, J M, Sommer, K A J, Bankhead, P, Kooreman, L F S, Schulte, J J, Cipriani, N A, Buelow, R D, Boor, P, Ortiz-Bruchle, N, Hanby, A M, Speirs, V, Kochanny, S, Patnaik, A, Srisuwananukorn, A, Brenner, H, Hoffmeister, M, Brandt, P A V D, Jäger, D, Trautwein, C, Pearson, A T & Luedde, T 2020, ' Pan-cancer image-based detection of clinically actionable genetic alterations ', nature cancer, vol. 1, no. 8, pp. 789–799 . https://doi.org/10.1038/s43018-020-0087-6

Molecular alterations in cancer can cause phenotypic changes in tumor cells and their microenvironment. Routine histopathology tissue slides, which are ubiquitously available, can reflect such morphological changes. Here, we show that deep learning c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5844bb58820a02ee29033be9fcdc522b
https://cris.maastrichtuniversity.nl/en/publications/054bcab0-00a9-4667-b697-9fbf758dba2f

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Autor: Alexander Marx, Takaki Yoshikawa, Jeremias Krause, Jenny Chang-Claude, Ulf P. Neumann, Christian Trautwein, Heike I. Grabsch, Niels Halama, Jakob Nikolas Kather, Michael Hoffmeister, Tom Luedde, Dirk Jäger, Alexander T. Pearson, Peter Boor, Hermann Brenner, Frank Tacke, Sven H. Loosen

Publikováno v: Nat Med
Nature Medicine
Nature medicine 25(7), 1054-1056 (2019). doi:10.1038/s41591-019-0462-y special issue: "Programmable bacteria fight tumors"
Nature Medicine, 25(7), 1054-1056. Nature Publishing Group

Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ebda104105683307f44065c3db50a0
https://pubmed.ncbi.nlm.nih.gov/31160815