Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili

Autor: Kimberly A. Coggan, Matthew G. Higgs, Evan D. Brutinel, Jeremiah N. Marden, Peter J. Intile, Hanne C. Winther-Larsen, Michael Koomey, Timothy L. Yahr, Matthew C. Wolfgang

Publikováno v: mBio, Vol 13, Iss 1 (2022)

ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa relies upon type IV pili (Tfp) for host colonization and virulence. Tfp are retractile surface appendages that promote adherence to host tissue and mediate twitching motility, a form of surfa

Externí odkaz: https://doaj.org/article/5e005aff4a7f4d8cb04e84fbfbf5906f

PmtA Regulates Pyocyanin Expression and Biofilm Formation in Pseudomonas aeruginosa

Autor: Jeremiah N. Marden, Joerg Graf, Clare Melchiorre, Amy V. Thees, Kathryn Pietrosimone, Michael A. Lynes, Michele Maltz-Matyschsyk

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 12 (2021)

The opportunistic pathogen Pseudomonas aeruginosa expresses a small molecular weight, cysteine-rich protein (PmtA), identified as a metallothionein (MT) protein family member. The MT family proteins have been well-characterized in eukaryotes as essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ea98b56fb4f9f7300445199cec3a5b
http://europepmc.org/articles/PMC8636135

Identification and characterization of putative Aeromonas spp. T3SS effectors

Autor: Sophie M. Colston, Jeremiah N. Marden, Joerg Graf, João C. Setubal, Luiz Thiberio Rangel, Johann Peter Gogarten

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0214035 (2019)

The genetic determinants of bacterial pathogenicity are highly variable between species and strains. However, a factor that is commonly associated with virulent Gram-negative bacteria, including manyAeromonasspp., is the type 3 secretion system (T3SS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21d0e90f03b0813071218085c31434d

An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa

Autor: Manisha R. Diaz, Cindy J. Gode, Laurie Betts, William G. Walton, Matthew C. Wolfgang, Matthew R. Redinbo, Mark L. Urbanowski, Jeremiah N. Marden, Timothy L. Yahr

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 110(37)

Members of the CsrA family of prokaryotic mRNA-binding proteins alter the translation and/or stability of transcripts needed for numerous global physiological processes. The previously described CsrA family member in Pseudomonas aeruginosa (RsmA) pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0415dd220deeec33329e47636bbc2270
https://pubmed.ncbi.nlm.nih.gov/23980177

Cyclic GMP controls Rhodospirillum centenum cyst development

Autor: Jeremiah N, Marden, Qian, Dong, Sugata, Roychowdhury, James E, Berleman, Carl E, Bauer

Publikováno v: Molecular microbiology. 79(3)

Adenylyl cyclases are widely distributed across all kingdoms whereas guanylyl cyclases are generally thought to be restricted to eukaryotes. Here we report that the α-proteobacterium Rhodospirillum centenum secretes cGMP when developing cysts and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fb3164a9b5143e86ee626281cbc9cce
https://pubmed.ncbi.nlm.nih.gov/21214648