Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeremiah J. Bearss"'
Autor:
Neha Singh, Varune R. Ramnarine, Jin H. Song, Ritu Pandey, Sathish K. R. Padi, Mannan Nouri, Virginie Olive, Maxim Kobelev, Koichi Okumura, David McCarthy, Michelle M. Hanna, Piali Mukherjee, Belinda Sun, Benjamin R. Lee, J. Brandon Parker, Debabrata Chakravarti, Noel A. Warfel, Muhan Zhou, Jeremiah J. Bearss, Ewan A. Gibb, Mohammed Alshalalfa, R. Jefferey Karnes, Eric J. Small, Rahul Aggarwal, Felix Feng, Yuzhuo Wang, Ralph Buttyan, Amina Zoubeidi, Mark Rubin, Martin Gleave, Frank J. Slack, Elai Davicioni, Himisha Beltran, Colin Collins, Andrew S. Kraft
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.
Externí odkaz:
https://doaj.org/article/fe3ffb322dcb47a8b750da286a3e5ab2
Autor:
Neha Singh, Sathish K. R. Padi, Jeremiah J. Bearss, Ritu Pandey, Koichi Okumura, Himisha Beltran, Jin H. Song, Andrew S. Kraft, Virginie Olive
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 974-990 (2020)
The proviral integration site for Moloney murine leukemia virus (PIM) serine/threonine kinases have an oncogenic and prosurvival role in hematological and solid cancers. However, the mechanism by which these kinases drive tumor growth has not been co
Externí odkaz:
https://doaj.org/article/b3dab6a6d6fa4a5b92c050c80dd2ee7e
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
Autor:
Neha Singh, Jaime M.C. Gard, Andrew D. L. Nelson, Jeremiah J. Bearss, J. Ross Buchan, Koichi Okumura, Marina Cardó-Vila, Yang Li, Wolfgang Peti, Anne E. Cress, Ghassan Mouneimne, Nikita Fernandes, Andrew S. Kraft, Jin H. Song, Sathish K.R. Padi, Matthew R. Harter
Publikováno v:
EMBO Rep
Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P‐bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to t
Autor:
Andrew S. Kraft, Marina Cardó-Vila, Koichi Okumura, Sathish K.R. Padi, Virginie Olive, Jeremiah J. Bearss, Jin H. Song, Neha Singh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(41)
The Pim and AKT serine/threonine protein kinases are implicated as drivers of cancer. Their regulation of tumor growth is closely tied to the ability of these enzymes to mainly stimulate protein synthesis by activating mTORC1 (mammalian target of rap
Autor:
Andrew S. Kraft, Koichi Okumura, Neha Singh, Sathish K.R. Padi, Virginie Olive, Jeremiah J. Bearss, Himisha Beltran, Ritu Pandey, Jin H. Song
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 14, Iss 5, Pp 974-990 (2020)
Molecular Oncology, Vol 14, Iss 5, Pp 974-990 (2020)
The proviral integration site for Moloney murine leukemia virus (PIM) serine/threonine kinases have an oncogenic and prosurvival role in hematological and solid cancers. However, the mechanism by which these kinases drive tumor growth has not been co
Autor:
Jeremiah J. Bearss, Andrew S. Kraft, Marina Cardó-Vila, Neha Singh, Sathish K.R. Padi, Koichi Okumura
Publikováno v:
Cancer Research. 81:2296-2296
Processing bodies (P-bodies) are cytoplasmic mRNA granules that form a hub to regulate mRNA translation via controlling decapping, degradation, and storage. P-bodies markedly increase as part of a stress response for example during nutrient deprivati
Autor:
James M Bogenberger, Katherine K. Soh, Steven D. Weitman, Wontak Kim, Steven L. Warner, David J. Bearss, Peter Peterson, Adam Siddiqui-Jain, Raoul Tibes, Jeremiah J. Bearss, Ye Sol Lee, Clifford J. Whatcott
Publikováno v:
Blood. 126:1343-1343
Despite significant efforts, the clinical mechanism of action of hypomethylating agents such as 5-azacytidine (5-aza) is still poorly understood. 5-aza is currently indicated for the treatment of patients with myelodysplastic syndrome (MDS). While 5-
Autor:
Steven D. Weitman, David J. Bearss, Brigham L. Bahr, Clifford J. Whatcott, Steven L. Warner, Ye Sol Lee, Katherine K. Soh, Jeremiah J. Bearss, Adam Siddiqui-Jain, Peter Peterson, Wontak Kim
Publikováno v:
Blood. 126:3799-3799
Alvocidib has demonstrated a significant improvement in the complete response rates of newly diagnosed acute myeloid leukemia (AML) patients when administered before cytarabine and mitoxantrone (FLAM regimen) in a randomized Phase 2 study compared to
Autor:
Peter Peterson, Wontak Kim, Clifford J. Whatcott, Adam Siddiqui-Jain, Jeremiah J. Bearss, Brigham L. Bahr, David J. Bearss, Katherine K. Soh, Steven L. Warner
Publikováno v:
Blood. 126:3253-3253
Mesenchymal stem cells (MSCs) contribute to the regeneration of mesenchymal tissues, and are essential in providing support for the growth and differentiation of primitive hemopoietic cells within the bone marrow microenvironment. It is becoming incr
Autor:
Jeremiah J. Bearss, Clifford J. Whatcott, Katherine K. Soh, Adam Siddiqui-Jain, Brigham L. Bahr, Ye Sol Lee, Steven L. Warner, Steven D. Weitman, David J. Bearss, Peter Peterson, Wontak Kim
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:S18