Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Jeremiah D, Momper"'
Autor:
Kian Falah, Patrick Zhang, Anisha K. Nigam, Koustav Maity, Geoffrey Chang, Jeffry C. Granados, Jeremiah D. Momper, Sanjay K. Nigam
Publikováno v:
Nutrients, Vol 16, Iss 14, p 2242 (2024)
The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8) are drug transporters that are expressed in the kidney, with well-established roles in the in vivo transport of drugs and endogenous metabolites. A comparatively unexplored potential fu
Externí odkaz:
https://doaj.org/article/7bfb421bd4ce42b6a1d1f113292a1742
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 592 (2024)
The movement of organic anionic drugs across cell membranes is partly governed by interactions with SLC and ABC transporters in the intestine, liver, kidney, blood–brain barrier, placenta, breast, and other tissues. Major transporters involved incl
Externí odkaz:
https://doaj.org/article/22cfc76d521c43cf8c27e293b99e5443
Autor:
Xiaomei I. Liu, André Dallmann, Kristina Brooks, Brookie M. Best, Diana F. Clarke, Mark Mirochnick, John N. van denAnker, Edmund V. Capparelli, Jeremiah D. Momper
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 148-153 (2023)
Abstract Pregnant individuals are at high risk for severe illness from COVID‐19, and there is an urgent need to identify safe and effective therapeutics for this population. Remdesivir (RDV) is a SARS‐CoV‐2 nucleotide analog RNA polymerase inhi
Externí odkaz:
https://doaj.org/article/d52f04c0444447639aa5582982613a39
Autor:
Ben Boyarko, Sonia Podvin, Barry Greenberg, Jeremiah D. Momper, Yadong Huang, William H. Gerwick, Anne G. Bang, Luisa Quinti, Ana Griciuc, Doo Yeon Kim, Rudolph E. Tanzi, Howard H. Feldman, Vivian Hook
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Therapeutics discovery and development for Alzheimer’s disease (AD) has been an area of intense research to alleviate memory loss and the underlying pathogenic processes. Recent drug discovery approaches have utilized in silico computational strate
Externí odkaz:
https://doaj.org/article/d3f3f5cf111246e3bec8557366792dd9
Autor:
Alan K. Jarmusch, Alison Vrbanac, Jeremiah D. Momper, Joseph D. Ma, Maher Alhaja, Marlon Liyanage, Rob Knight, Pieter C. Dorrestein, Shirley M. Tsunoda
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 5, Pp 972-984 (2020)
Determining factors that contribute to interindividual and intra‐individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability
Externí odkaz:
https://doaj.org/article/4fae86d0d1c641e49a64ed7b6b51323f
Autor:
María L. Cafferata, María A. Toscani, Fernando Althabe, Jose M. Belizán, Eduardo Bergel, Mabel Berrueta, Edmund V. Capparelli, Álvaro Ciganda, Emmaria Danesi, Eric Dumonteil, Luz Gibbons, Pablo E. Gulayin, Claudia Herrera, Jeremiah D. Momper, Steven Rossi, Jeffrey G. Shaffer, Alejandro G. Schijman, Sergio Sosa-Estani, Candela B. Stella, Karen Klein, Pierre Buekens
Publikováno v:
Reproductive Health, Vol 17, Iss 1, Pp 1-23 (2020)
Resumen (Spanish) Antecedentes Estudios observacionales retrospectivos sugieren que la transmisión del Trypanosoma cruzi no ocurre en mujeres tratadas cuando quedan embarazadas más adelante. La carga parasitaria en la sangre es un factor de riesgo
Externí odkaz:
https://doaj.org/article/683cfa5293dc4f14bd873f0d1058feaf
Autor:
Morgan Panitchpakdi, Kelly C. Weldon, Alan K. Jarmusch, Emily C. Gentry, Arianna Choi, Yadira Sepulveda, Shaden Aguirre, Kunyang Sun, Jeremiah D. Momper, Pieter C. Dorrestein, Shirley M. Tsunoda
Publikováno v:
PLoS ONE, Vol 17, Iss 7 (2022)
Clinical testing typically relies on invasive blood draws and biopsies. Alternative methods of sample collection are continually being developed to improve patient experience; swabbing the skin is one of the least invasive sampling methods possible.
Externí odkaz:
https://doaj.org/article/d127b390ce8e45eb868dec29462c4c88
Autor:
Sherry Zhao, Mary Gockenbach, Manuela Grimstein, Hari Cheryl Sachs, Mark Mirochnick, Kimberly Struble, Yodit Belew, Jian Wang, Edmund V. Capparelli, Brookie M. Best, Tamara Johnson, Jeremiah D. Momper, Anil R. Maharaj
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokinetics. Physiologically-based pharmacokinetic (PBPK) models can serve to inform drug dosing decisions in unde
Externí odkaz:
https://doaj.org/article/255de7edd5bf4599bab6e29d0798c310
Autor:
Xiaomei I. Liu, Dionna J. Green, John N. van den Anker, Natella Y. Rakhmanina, Homa K. Ahmadzia, Jeremiah D. Momper, Kyunghun Park, Gilbert J. Burckart, André Dallmann
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: While physiologically based pharmacokinetic (PBPK) models generally predict pharmacokinetics in pregnant women successfully, the confidence in predicting fetal pharmacokinetics is limited because many parameters affecting placental drug t
Externí odkaz:
https://doaj.org/article/f4541b75f8c84cbd94df9dab5d82a079
Autor:
Kensuke Shoji, Jumpei Saito, Hidenori Nakagawa, Takanori Funaki, Akinari Fukuda, Seisuke Sakamoto, Mureo Kasahara, Jeremiah D. Momper, Edmund V. Capparelli, Isao Miyairi
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Methicillin-resistant Staphylococcus aureus infections are a significant cause of morbidity and mortality in pediatric liver transplant (LT) recipients. Physiological changes following LT may affect vancomycin pharmacokinetics; however, appr
Externí odkaz:
https://doaj.org/article/87a74edb86db42bca17204276cec3163