COVID-19 patients display changes in lymphocyte subsets with a higher frequency of dysfunctional CD8lo T cells associated with disease severity

Autor: Luisina Ines Onofrio, Constanza Marin, Jeremías Dutto, María Belén Brugo, Ruth Eliana Baigorri, Sabrina Noemi Bossio, Juan Nahuel Quiróz, Laura Almada, Federico Ruiz Moreno, Carolina Olivera, Silene M. Silvera-Ruiz, Nicolás Eric Ponce, Paula Alejandra Icely, María Carolina Amezcua Vesely, Laura Fozzatti, María Cecilia Rodríguez-Galán, Cinthia Carolina Stempin, Laura Cervi, ImmunoCovid-CBA, Belkys Angélica Maletto, Eva Virginia Acosta Rodríguez, Mariana Bertone, Claudio Daniel Abiega, Daiana Escudero, Adrián Kahn, Juan Pablo Caeiro, Mariana Maccioni, Claudia Cristina Motrán, Adriana Gruppi, Claudia Elena Sotomayor, Laura Silvina Chiapello, Carolina Lucia Montes, Fabio Cerban, Pablo Iribarren, Daniela Soledad Arroyo, Gabriel Moron

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

This work examines cellular immunity against SARS-CoV-2 in patients from Córdoba, Argentina, during two major waves characterized by different circulating viral variants and different social behavior. Using flow cytometry, we evaluated the main lymp

Externí odkaz: https://doaj.org/article/63f9ae4b37974b18965ff300505a53e7

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

Autor: Gerardo Gatti, Courtney Betts, Darío Rocha, Maribel Nicola, Verónica Grupe, Cecilia Ditada, Nicolas G. Nuñez, Emiliano Roselli, Paula Araya, Jeremías Dutto, Lucia Boffelli, Elmer Fernández, Lisa M. Coussens, Mariana Maccioni

Publikováno v: Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)

Abstract Background Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2, and Ki67 has been useful as a predictive and therapeutic tool. Also, assessment of tumor-infiltrating lymphocytes has b

Externí odkaz: https://doaj.org/article/2407c5f713e8417d9bcfd3f90edf443d

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

Autor: Emiliano Roselli, Cecilia Ditada, Elmer Andrés Fernández, Mariana Maccioni, Maribel Nicola, Courtney Betts, Darío Rocha, Lisa M. Coussens, Verónica Grupe, Gerardo Gatti, Lucia Boffelli, Nicolás Gonzalo Núñez, Paula Araya, Jeremías Dutto

Publikováno v: Breast Cancer Research : BCR
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)
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Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2 and Ki67 has been useful as a predictive and therapeutic tool. Also, assessment of tumor-infiltrating lymphocytes has been proposed as an im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff673914fb22b58ae9c0b7bc0891c4
https://pubmed.ncbi.nlm.nih.gov/33888121