Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Jere P, Segrest"'
Autor:
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL). Here, the authors use simulations to assess the mechanism of AB
Externí odkaz:
https://doaj.org/article/fabaa2042cb346d69e7b13267b43befc
Autor:
Shimpi Bedi, Jamie Morris, Amy Shah, Rachel C. Hart, W. Gray Jerome, Stephen G. Aller, Chongren Tang, Tomas Vaisar, Karin E. Bornfeldt, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100168- (2022)
Because of its critical role in HDL formation, significant efforts have been devoted to studying apolipoprotein A-I (APOA1) structural transitions in response to lipid binding. To assess the requirements for the conformational freedom of its termini
Externí odkaz:
https://doaj.org/article/85e2394e2ac54dddbe32143770942ea7
Autor:
Stephen G Aller, Jere P Segrest
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0262746 (2022)
ABCA1 and ABCA4 are enigmatic because they transport substrates in opposite directions yet share >50% amino acid identity. ABCA4 imports lipid conjugates but ABCA1 exports lipids. Both hydrolyze ATP to drive transport, and both contain cytoplasmic re
Externí odkaz:
https://doaj.org/article/e6291241e92d47a8a335a5d72ea6ab61
Autor:
John T. Melchior, Scott E. Street, Tomas Vaisar, Rachel Hart, Jay Jerome, Zsuzsanna Kuklenyik, Noemie Clouet-Foraison, Carissa Thornock, Shimpi Bedi, Amy S. Shah, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100099- (2021)
Human high-density lipoproteins (HDLs) are a complex mixture of structurally related nanoparticles that perform distinct physiological functions. We previously showed that human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein A-II (A
Externí odkaz:
https://doaj.org/article/7ba703fa36364086ac73b700fa50b5e4
Autor:
Allison L. Cooke, Jamie Morris, John T. Melchior, Scott E. Street, W.Gray Jerome, Rong Huang, Andrew B. Herr, Loren E. Smith, Jere P. Segrest, Alan T. Remaley, Amy S. Shah, Thomas B. Thompson, W.Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1244-1255 (2018)
APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-pa
Externí odkaz:
https://doaj.org/article/60cd0651eb994e51bcbbc5b9d090567b
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 620-634 (2015)
LCAT is activated by apoA-I to form cholesteryl ester. We combined two structures, phospholipase A2 (PLA2) that hydrolyzes the ester bond at the sn-2 position of oxidized (short) acyl chains of phospholipid, and bacteriophage tubulin PhuZ, as C- and
Externí odkaz:
https://doaj.org/article/56d0ea2feeec4c4193719fb62e6d3b66
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3244-3257 (2013)
HDL removes cell cholesterol and protects against atherosclerosis. ApoA-I provides a flexible structural scaffold and an important functional ligand on the HDL surface. We propose structural models for apoA-IMilano (R173C) and apoA-IParis (R151C) mut
Externí odkaz:
https://doaj.org/article/31a532c41c8443b4a32af3b1de33b44b
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2733-2744 (2013)
Although HDL is inversely correlated with coronary heart disease, elevated HDL-cholesterol is not always protective. Additionally, HDL has biological functions that transcend any antiatherogenic role: shotgun proteomics show that HDL particles contai
Externí odkaz:
https://doaj.org/article/6daa8b01785945a88ce8e2a58fba86d8
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2718-2732 (2013)
Since spheroidal HDL particles (sHDL) are highly dynamic, molecular dynamics (MD) simulations are useful for obtaining structural models. Here we use MD to simulate sHDL with stoichiometries of reconstituted and circulating particles. The hydrophobic
Externí odkaz:
https://doaj.org/article/a4efc8c8b38e45c09b7e21a506635110
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1939-1948 (2013)
Many of the apolipoproteins in HDL can elicit cholesterol efflux via ABCA1, a critical initial step in HDL formation. Recent work has indicated that omnipresent amphipathic helices play a critical role, and these have been studied intensively in the
Externí odkaz:
https://doaj.org/article/72782ba5628349fb9bc2e3149bba4439