Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jere E Meredith"'
Autor:
Jere E Meredith, Sethu Sankaranarayanan, Valerie Guss, Anthony J Lanzetti, Flora Berisha, Robert J Neely, J Randall Slemmon, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Holly Soares, Michael Ahlijanian, Charles F Albright
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76523 (2013)
Cerebral spinal fluid (CSF) Aβ42, tau and p181tau are widely accepted biomarkers of Alzheimer's disease (AD). Numerous studies show that CSF tau and p181tau levels are elevated in mild-to-moderate AD compared to age-matched controls. In addition, th
Externí odkaz:
https://doaj.org/article/1cf423c06b374b6aa3a7e3df8f786b15
Autor:
Amy Easton, Marianne L. Jensen, Congwei Wang, Peter H. Hagedorn, Yuwen Li, Michael Weed, Jere E. Meredith, Valerie Guss, Kelli Jones, Martin Gill, Carol Krause, Jeffrey M. Brown, Lisa Hunihan, Joanne Natale, Alda Fernandes, Yifeng Lu, Joe Polino, Mark Bookbinder, Greg Cadelina, Yulia Benitex, Ramola Sane, John Morrison, Dieter Drexler, Stephen E. Mercer, Charlotte Bon, Nikhil J. Pandya, Ravi Jagasia, Tai-Hsien Ou Yang, Tania Distler, Fiona Grüninger, Michael Meldgaard, Marco Terrigno, John E. Macor, Charles F. Albright, James Loy, Anja M. Hoeg, Richard E. Olson, Angela M. Cacace
Publikováno v:
Molecular therapy. Nucleic acids. 29
Tau is a microtubule-associated protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc4302dcff03d41215dd8c99c37d729
https://pubmed.ncbi.nlm.nih.gov/36090761
https://pubmed.ncbi.nlm.nih.gov/36090761
Autor:
John E. Macor, Yunhui Zhang, James E. Grace, Lorin A. Thompson, Jeremy H. Toyn, Lawrence R. Marcin, Subramaniam Krishnananthan, Jianliang Shi, Dmitry Zuev, Daniel Smith, Jianqing Li, Yong-Jin Wu, Jason M. Guernon, Xiaoliang Zhuo, Tatyana Zvyaga, Xu Li, Arvind Mathur, John Morrison, Jere E. Meredith, Charles F. Albright, S. Roy Kimura, Mendi A. Higgins, Kimberley A. Lentz, Richard E. Olson, Rex Denton, Kenneth M. Boy, Catherine R. Burton, Ashok K. Trehan, Michael K. Ahlijanian
Publikováno v:
ACS Medicinal Chemistry Letters
A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed62d494eee5e78e1c6f0f7838951135
http://europepmc.org/articles/PMC6421538
http://europepmc.org/articles/PMC6421538
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
Alan S. Robertson, Dieter M. Drexler, Michael K. Ahlijanian, Lawrence G. Iben, Charles F. Albright, Richard E. Olson, Lorin A. Thompson, Martyn Banks, Gregory D. Vite, Jeremy H. Toyn, Cong Wei, Jere E. Meredith
Publikováno v:
European Journal of Pharmacology. 812:104-112
Alzheimer's disease is associated with the accumulation of amyloid-β (Aβ) in the brain. In particular, the 42-amino acid form, Aβ1-42, is thought to play a key role in the disease. It is therefore of interest that diverse compounds, known as γ-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ef13a72a3178b74444c96d0fe0f4ee
https://doi.org/10.1016/j.ejphar.2017.07.019
https://doi.org/10.1016/j.ejphar.2017.07.019
Autor:
Joseph L. Cantone, Cong Wei, Michael K. Ahlijanian, Craig Polson, Valerie Guss, Jere E. Meredith, Dieter M. Drexler
Publikováno v:
Analytical Methods. 9:3477-3484
The research on neurodegenerative diseases is challenged by accurate disease diagnosis and evaluation of treatment response, thus there is a need for indicators at the molecular level, specifically biomarkers, that reliably provide disease diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4547f3d6229cf0d7aff659951eb5a83
https://doi.org/10.1039/c7ay00869d
https://doi.org/10.1039/c7ay00869d
Autor:
Craig Polson, John D. Graef, Nina Hoque, Lawrence G. Iben, Yang Cao, Jere E. Meredith, Nino Devidze, Ling Yang, Michael K. Ahlijanian
Synucleinopathies are a group of neurodegenerative diseases characterized by the presence of pathological accumulations of misfolded, phosphorylated α-synuclein (αSyn) protein. Multiple lines of evidence indicate that synucleinopathy disease progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c91ec852b8b0650639d9646e82a1897
Autor:
John Morrison, Kenneth M. Boy, Alan S. Robertson, Malaz AbuTarif, Jeremy H. Toyn, Valerie Guss, Xiaoliang Zhuo, Maciej Gasior, James E. Grace, Cong Wei, Jun-Sheng Wang, Quan Hong, Joseph Raybon, Lynda S. Cook, Nina Hoque, Richard E. Olson, Wendy Clarke, Rex Denton, Lorin A. Thompson, Francis Sweeney, Flora Berisha, Jere E. Meredith, Dieter M. Drexler, Holly Soares, Kimberly A. Lentz, Charlie F. Albright, Ramesh Padmanabha, Michael J. Furlong, John E. Macor, Michael K. Ahlijanian, Dmitry Zuev, Kimberly Snow
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The amyloid-β peptide (Aβ)-in particular, the 42-amino acid form, Aβ1-42-is thought to play a key role in the pathogenesis of Alzheimer's disease (AD). Thus, several therapeutic modalities aiming to inhibit Aβ synthesis or increase the clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c27817650721b910af7d1d2e922680b
https://doi.org/10.1124/jpet.116.232249
https://doi.org/10.1124/jpet.116.232249
Autor:
Andrew C. Good, Joe Shi, Catherine R. Burton, Samuel Gerritz, John E. Macor, Weixu Zhai, Shirong Zhu, Richard E. Olson, Jeremy H. Toyn, James E. Grace, Donna M. Barten, Yunhui Zhang, Jere E. Meredith, Kimberley A. Lentz, Lorin A. Thompson, Yong-Jin Wu, Charles F. Albright, Jason M. Guernon, Kenneth M. Boy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5040-5047
The synthesis, evaluation, and structure-activity relationships of a class of acyl guanidines which inhibit the BACE-1 enzyme are presented. The prolinyl acyl guanidine chemotype (7c), unlike compounds of the parent isothiazole chemotype (1), yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b930dff1463e1d5670f3e942574f4e4b
https://doi.org/10.1016/j.bmcl.2015.10.031
https://doi.org/10.1016/j.bmcl.2015.10.031
Autor:
Claude A. Quesnelle, Patrice Gill, Richard Rampulla, Ching Su, Gerry Everlof, George L. Trainor, Ke Chen, Vinod Arora, Richard A. Westhouse, Celia D’Arienzo, Andrew J. Tebben, Weifang Shan, John T. Hunt, Derek J. Norris, Louis J. Lombardo, Zheng Yang, Arvind Mathur, Mei-Li Wen, Yingru Zhang, Dauh-Rurng Wu, Wen-Ching Han, Krista Menard, Victor R. Guarino, Asoka Ranasinghe, Richard E. Olson, Ashvinikumar V. Gavai, Bruce S. Fischer, Phil S. Baran, Anne Rose, Lan Xiao, Ronald E. White, Mary Ellen Cvijic, Gregory D. Vite, Ding Ren Shen, Jere E. Meredith, Haiqing Wang, Francis Y. Lee, Aaron Balog
Publikováno v:
ACS Medicinal Chemistry Letters. 6:523-527
Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On the basis of its robust in vivo efficacy at tolerated dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3995231a45ba8104a424851cf0a94b
https://doi.org/10.1021/acsmedchemlett.5b00001
https://doi.org/10.1021/acsmedchemlett.5b00001