Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jerald J. McClenahan"'
Autor:
Radhika Venkataraman, William C. Groutas, He Huang, Jeffrey B. Epp, Lee S. Chong, Nadene Houser-Archield, Jerald J. McClenahan
Publikováno v:
Journal of Medicinal Chemistry. 36:3178-3181
A series of saccharin derivatives I has been synthesized and evaluated for their inhibitory activity toward human leukocyte elastase and cathepsin G. Most of the compounds were found to be efficient and time-dependent inhibitors of elastase. Inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a8b9a86cb28ded84330ecf597d71b1
https://doi.org/10.1021/jm00073a019
https://doi.org/10.1021/jm00073a019
Autor:
Michael A. Stanga, Jeffrey B. Epp, Lee S. Chong, William C. Groutas, Jerald J. McClenahan, Radhika Venkataraman, Michael J. Brubaker, F. Tagusagawa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1164:283-288
A series of 3-( alkylthio )-N- hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether side chain (compounds 1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540c6b7189a0c443faec00a5d10c6acf
https://doi.org/10.1016/0167-4838(93)90260-x
https://doi.org/10.1016/0167-4838(93)90260-x
Autor:
Radhika Venkataraman, He Huang, Nadene Houser-Archield, Lee S. Chong, Jeffrey B. Epp, Jerald J. McClenahan, Rongze Kuang, Michael J. Brubaker, William C. Groutas
Publikováno v:
Biochemical and Biophysical Research Communications. 194:1491-1499
Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro inhibitory activity of some n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7684fefef7c072ee920afbe26f4475
https://doi.org/10.1006/bbrc.1993.1993
https://doi.org/10.1006/bbrc.1993.1993
Autor:
William C. Groutas, Michael J. Brubaker, Charles E. Keller, Jerald J. McClenahan, He Huang, Jeffrey B. Epp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1565-1570
A general approach toward the rational design of potential inhibitors of serine proteinases is described. The approach is exemplified and validated through the use of appropriate heterocyclic systems in inhibiting human leukocytes elastase (HLE).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b27102e3cabf487589a2f0640ff7ab3
https://doi.org/10.1016/s0960-894x(00)80431-x
https://doi.org/10.1016/s0960-894x(00)80431-x
Autor:
Michael J. Brubaker, Jeffrey B. Epp, Lee S. Chong, William C. Groutas, Nadene Houser-Archield, Jerald J. McClenahan, Radhika Venkataraman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:175-180
The design, synthesis, and inhibitory activity toward human neutropil elastase, of a series of potential mechanims-based inhibitors is described. The design, synthesis, and inhibitory activity toward human neutrophile elastase, of a series of potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c47b25163211209d000d6e70049936dc
https://doi.org/10.1016/s0960-894x(01)80445-5
https://doi.org/10.1016/s0960-894x(01)80445-5
Autor:
Michael J. Brubaker, Radhika Venkataraman, William C. Groutas, Jeffrey B. Epp, Michael A. Stanga, Jerald J. McClenahan
Publikováno v:
Archives of biochemistry and biophysics. 294(1)
The interaction of a series of sulfonate and phosphate esters derived from N-hydroxysuccinimide with human leukocyte cathepsin G was investigated. The synthesized compounds were found to be time-dependent inhibitors of the enzyme. The composite inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b5efa6eed8fbfa9dbde17816c8cf27
https://pubmed.ncbi.nlm.nih.gov/1497704
https://pubmed.ncbi.nlm.nih.gov/1497704