Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jerald J. Killion"'
Publikováno v:
International Journal of Immunopharmacology. 22:431-443
We determined whether the expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMPs (TIMP) in murine macrophages is regulated by the novel synthetic bacterial lipopeptide JBT 3002. Multilamellar liposomes (MLV) encapsulating JBT 300
Autor:
Jerald J. Killion, Alan J. Schroit
Publikováno v:
Emerging Therapeutic Targets. 3:453-468
Cell membranes contain numerous species of glycosphingolipids (GSL) and glycerophospholipids. Changes in the surface expression of these moieties that accompany malignant transformation are potential targets for immune therapies. There is increasing
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 14:221-230
We determined whether the angiogenesis and growth of murine colon carcinomas growing in the wall of the cecum is dependent on infiltrating leukocytes. Syngeneic BALB/c or SCID mice were treated with a myelosuppressive, maximally tolerated dose of dox
Publikováno v:
Thrombosis Research. 92:91-97
Beta-2-glycoprotein I (beta2GPI), a 50-kDA serum glycoprotein that binds negatively charged phospholipids plays a role in coagulation, thrombosis, and the clearance of phosphatidylserine expressing cells. Because of its recently recognized role in se
Publikováno v:
Journal of Immunotherapy. 21:340-351
We studied activation to the tumoricidal state of murine peritoneal macrophages by liposomes containing a new synthetic analogue, JBT3002, of a lipoprotein from the outer wall of a gram-negative bacterium. The liposomes containing JBT3002 or CGP31362
Autor:
Steven J. Norris, Eric L. Brown, L C Stephens, Jerald J. Killion, Michael W. Pride, Margaret L. Kripke
Publikováno v:
Journal of Leukocyte Biology. 63:542-549
Although humoral responses to Borrelia burgdorferi (Bb) have been shown to be protective in some animal models of Lyme disease, the role of T cells in this disease is less well understood. This work describes three Bb-specific T cell lines that preve
Publikováno v:
Cancer and Metastasis Reviews. 17:279-284
Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of cancer and elucidation of their mechanisms of action require the use of relevant animal models. It is well established that the faithful reproduction of the tum
Autor:
Jerald J. Killion, Colin P.N. Dinney, Randi Fishbeck, Dominic Fan, Corazon D. Bucana, Beryl Y. Eve, Nicholas Brown, Rakesh K. Singh, Isaiah J. Fidler, Bei Xie, Sen Pathak
Publikováno v:
The Journal of Urology. :1532-1538
Purpose: These studies were designed to develop an orthotopic model for human bladder cancer and to isolate variant metastatic cell lines.Materials and Methods: The human bladder cancer cell line 253J was implanted into the muscular wall of the bladd
Publikováno v:
Cytokine. 6:443-449
The antiproliferative effect of interferon alpha (IFN-alpha) against cultured 253J human bladder tumour cells was enhanced when IFN-alpha was encapsulated into multilamellar phospholipid liposomes (MLV). Moreover, significant cytostasis of a variant