Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jer-Hong Chong"'
Autor:
Lin Zhang, Annie Raditsis, Istvan J. Enyedy, Jianhua Chao, Ishchenko Alexey, Brian Elenbaas, Laura Silvian, Jer Hong Chong, Victor Sukbong Hong, Douglas Marcotte, Junhua Fan, Aparna Hingway, Jean-Yves Le Brazidec, Latika Singh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:474-480
PIM kinases are implicated in variety of cancers by promoting cell survival and proliferation and are targets of interest for therapeutic intervention. We have identified a low-nanomolar pan-PIM inhibitor (PIM1/2/3 potency 5:14:2nM) using structure b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f957718a29c892d89d0d2f01a1c02c95
https://doi.org/10.1016/j.bmcl.2014.12.041
https://doi.org/10.1016/j.bmcl.2014.12.041
Autor:
Lin Zhang, Art Taveras, Jer-Hong Chong, Jianhua Chao, Min Teng, Nuzhat Pathan, Angela Pasis, Betty Tam, Jean-Yves Le Brazidec, Michael J. Choi, Junhua Fan, Leona E. Ling, Deping Wang, Christina Boykin, Cheryl Black, Tony Li, Khanh Nguyen, Shuo Zhao, Laura Silvian, Gisela Claassen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2070-2074
Since the early 2000s, the Aurora kinases have become major targets of oncology drug discovery particularly Aurora-A and Aurora-B kinases (AKA/AKB) for which the selective inhibition in cells lead to different phenotypes. In addition to targeting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305d6a2f7a009fcf16ad3cbdfedcb372
https://doi.org/10.1016/j.bmcl.2012.01.019
https://doi.org/10.1016/j.bmcl.2012.01.019
Publikováno v:
Journal of Propulsion and Power. 19:497-505
In the course of exploiting spacecraft formations for use in separated interferometry (or other missions), it is possible that the separation distance between vehicles will be on the order of 10 m. The effects of spacecraft charging on the dynamics o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b797bbb1ad0a157bbbae786174e97ab
https://doi.org/10.2514/2.6133
https://doi.org/10.2514/2.6133
Autor:
Jer-Hong Chong, Michael J. Choi, Douglas Marcotte, Tony Li, Junhua Fan, Deping Wang, Leona E. Ling, Lin Zhang, Art Taveras, Nuzhat Pathan, Khanh Nguyen, Min Teng, Gisela Claassen, Jean-Yves Le Brazidec, Shuo Zhao, Christina Boykin, Betty Tam, Laura Silvian, Angela Pasis, Jianhua Chao
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(12)
This Letter reports the optimization of a pyrrolopyrimidine series as dual inhibitors of Aurora A/B kinases. This series derived from a pyrazolopyrimidine series previously reported as inhibitors of aurora kinases and CDKs. In an effort to improve th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04c16b379ccb805ccedbd00429b130f
https://pubmed.ncbi.nlm.nih.gov/22607669
https://pubmed.ncbi.nlm.nih.gov/22607669
Autor:
Liang-Shang Gan, Betty Tam, Khang Vu, Jinhua Piao, Douglas Marcotte, Shuo Zhao, Min Teng, Jianhua Chao, Charles A. Iii Gilson, Dikran Aivazian, Qin Wang, Guangqing Xiao, Arthur G. Taveras, Samina Khan, Tony Li, Junhua Fan, Jean-Yves Le Brazidec, Wen-Cherng Lee, Noel Timple, Khanh Nguyen, Lin Zhang, Jer-Hong Chong, Kevin Hong, Laura Silvian, Nicole Takeda, Mitchell Reff, Angela Cesena, Ron A. Morena, Deping Wang, Karen Lundgren, Leona E. Ling, Christina Boykin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
A novel class of pyrazolopyrimidine-sulfonamides was discovered as selective dual inhibitors of aurora kinase A (AKA) and cyclin-dependent kinase 1 (CDK1). These inhibitors were originally designed based on an early lead (compound I). SAR development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c36dadf5f7bf00efcdb5a0ac2fe8944
https://pubmed.ncbi.nlm.nih.gov/21798738
https://pubmed.ncbi.nlm.nih.gov/21798738