Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jer R. Kuszak"'
Autor:
Juliet A Moncaster, Roberto Pineda, Robert D Moir, Suqian Lu, Mark A Burton, Joy G Ghosh, Maria Ericsson, Stephanie J Soscia, Anca Mocofanescu, Rebecca D Folkerth, Richard M Robb, Jer R Kuszak, John I Clark, Rudolph E Tanzi, David G Hunter, Lee E Goldstein
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10659 (2010)
Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease
Externí odkaz:
https://doaj.org/article/68140f0c02854f30afc460197196eda9
Autor:
Brian J. Day, Jer R. Kuszak, Gregg Duester, J. Bronwyn Bateman, Tia Estey, Lisa M. Hines, Natalie Lassen, Joram Piatigorsky, Vasilis Vasiliou, Jie Huang, David W. Nees
Publikováno v:
Journal of Biological Chemistry. 282:25668-25676
ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cornea but undetectable in the lens, and ALDH1A1 is present at lower (catalytic) levels in the cornea and lens. To test the hypothesis that ALDH3A1 and ALDH1A1 protect the anterior segment
Autor:
Benjamin Heilbrunn, Eric C. Beyer, Peter J. Minogue, June Chung, Rebecca K. Zoltoski, L.A. Novak, Lisa Ebihara, Xiaoqin Liu, Jer R. Kuszak, Viviana M. Berthoud
Publikováno v:
Experimental Eye Research. 84:513-528
To examine the effects of increased expression of Cx50 in the mouse lens, transgenic mice were generated using a DNA construct containing the human Cx50 coding region and a C-terminal FLAG epitope driven by the chicken betaB1-crystallin promoter. Exp
Autor:
Alan R. Prescott, A.M. Hutcheson, Jer R. Kuszak, Shigeo Masaki, Alfred Wegener, Aileen Sandilands, Rebecca K. Zoltoski, Roy A. Quinlan
Publikováno v:
Experimental Eye Research. 76:385-391
In this report, the phenotype associated with the first targeted knockout of the lens specific intermediate filament gene CP49 is described. Several surprising observations have been made. The first was that no cataract was observed despite the fact
Publikováno v:
Experimental Eye Research. 72:533-545
Populations of control, C, and glutathione peroxidase-1 (GPx-1) knockout mice, K, were studied over a period of 2 years. No significant difference was observed between the C and K populations with respect to longevity, vitality, weight, lens biochemi
Autor:
Christopher D. Freel, K. J. Al-Ghoul, Jer R. Kuszak, Rachel K. Nordgren, M. Joseph Costello, Adam J. Kuszak
Publikováno v:
Experimental Eye Research. 72:199-214
This study was conducted to quantify structural change associated with human nuclear fiber compaction as a function of ageing and nuclear cataract formation. Normal donor lenses in three age ranges, young (15–25 years), middle-aged (36–46 years)
Publikováno v:
Journal of Cataract and Refractive Surgery. 25:268-277
Purpose: To quantitatively analyze the clarity of regenerated lens material afterendocapsular lens extraction and restoration of the lens capsular bag with and without implantation of an intralenticular disc lens. Setting: Shepherd Research Center, A
Autor:
Rudolph E. Tanzi, Stephanie J. Soscia, Suqian Lu, Rebecca D. Folkerth, Joy Ghosh, Anca Mocofanescu, Jer R. Kuszak, Maria Ericsson, Richard M. Robb, Roberto Pineda, Juliet A. Moncaster, David G. Hunter, Mark Burton, Robert D. Moir, John I. Clark, Lee E. Goldstein
Publikováno v:
Alzheimer's & Dementia. 6
Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication of chromosome 21 invariably includes the APP gene (21q21) encoding the Alzheimer's disease
Autor:
Yajun Tang, R. Antonio Herrera, Xiangyang Liu, Isabelle Richard, Jer R. Kuszak, Rebecca K. Zoltoski, L.A. Novak, Nalin M. Kumar
Publikováno v:
Investigative ophthalmologyvisual science. 48(6)
Gap junctions consist of two hexameric structures of connexin (Cx) molecules called connexons, which are located in the plasma membranes of two neighboring cells. So far, more than 20 connexin genes have been identified in vertebrates.1,2 Three conne
Publikováno v:
Molecular vision. 12
The purpose of this study was to use qualitative and quantitative structural data from nonprimate lenses with branched (Y and line) sutures to generate computer models (animations) of secondary fiber development and suture formation.A minimum of 12-1