Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jerónimo Rodríguez-Beltran"'
Autor:
Thi Thuy Do, Jerónimo Rodríguez-Beltran, Esmeralda Cebrián-Sastre, Alexandro Rodríguez-Rojas, Alfredo Castañeda-García, Jesús Blázquez
Publikováno v:
Antibiotics, Vol 11, Iss 4, p 509 (2022)
Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. Rifampicin resistance in mycobacteria is mainly caused by mutations in the rpoB gene; ho
Externí odkaz:
https://doaj.org/article/5815e3ea947647d789c7381c438a95d9
Autor:
Cristina Herencias, Laura Álvaro-Llorente, Paula Ramiro-Martínez, Ariadna Fernández-Calvet, Ada Muñoz-Cazalla, Javier DelaFuente, Fabrice E. Graf, Laura Jaraba-Soto, Juan Antonio Castillo-Polo, Rafael Cantón, Álvaro San Millán, Jerónimo Rodríguez-Beltrán
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Major antibiotic groups are losing effectiveness due to the uncontrollable spread of antimicrobial resistance (AMR) genes. Among these, β-lactam resistance genes –encoding β-lactamases– stand as the most common resistance mechanism in
Externí odkaz:
https://doaj.org/article/4459ee25c64b452a9a925117443935ea
Autor:
J. Carlos R. Hernandez-Beltran, Jerónimo Rodríguez-Beltrán, Oscar Bruno Aguilar-Luviano, Jesús Velez-Santiago, Octavio Mondragón-Palomino, R. Craig MacLean, Ayari Fuentes-Hernández, Alvaro San Millán, Rafael Peña-Miller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The rise of antibiotic resistance is a critical public health concern, requiring an understanding of mechanisms that enable bacteria to tolerate antimicrobial agents. Bacteria use diverse strategies, including the amplification of drug-resis
Externí odkaz:
https://doaj.org/article/e03a6d9559a543168547e6a8826f40dc
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT This year we commemorate the centennial of the birth of the mature concept of bacteriostasis by John W. Churchman at Cornell University Medical School. The term bacteriostasis has primarily been applied to antibiotics (bacteriostatic antibio
Externí odkaz:
https://doaj.org/article/158619463a094c399d4dda7a7b9dd72b
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 76 (2024)
The acquisition and expression of antibiotic resistance implies changes in bacterial cell physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as those causing urinary tract or bloodstream infections, colonize the gu
Externí odkaz:
https://doaj.org/article/ab083c925d924814af4681d7b8df299e
Autor:
Aida Alonso-del Valle, Ricardo León-Sampedro, Jerónimo Rodríguez-Beltrán, Javier DelaFuente, Marta Hernández-García, Patricia Ruiz-Garbajosa, Rafael Cantón, Rafael Peña-Miller, Alvaro San Millán
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The variability of plasmid fitness effects on wild-type bacterial hosts have been largely unknown until this study, which shows that plasmid persistence increases with bacterial diversity and becomes less dependent on conjugation. This could explain
Externí odkaz:
https://doaj.org/article/46212f3f45ec448aae37660a0d2c7cb6
Autor:
Fernando Baquero, José-Luis Martínez, Alvaro Sánchez, Miguel D. Fernández-de-Bobadilla, Alvaro San-Millán, Jerónimo Rodríguez-Beltrán
Publikováno v:
Biology, Vol 12, Iss 5, p 640 (2023)
Epistasis refers to the way in which genetic interactions between some genetic loci affect phenotypes and fitness. In this study, we propose the concept of “structural epistasis” to emphasize the role of the variable physical interactions between
Externí odkaz:
https://doaj.org/article/a2c95856157448daa0dcd45f330a5ce8
Autor:
Fernando Baquero, José L. Martínez, Ângela Novais, Jerónimo Rodríguez-Beltrán, Laura Martínez-García, Teresa M. Coque, Juan Carlos Galán
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Allogeneous selection occurs when an antibiotic selects for resistance to more advanced members of the same family. The mechanisms of allogenous selection are (a) collateral expansion, when the antibiotic expands the gene and gene-containing bacteria
Externí odkaz:
https://doaj.org/article/c9e787fd8bed47439798934e15ff3fa7
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001308 (2021)
The horizontal transfer of mobile DNA is one of the signature moves of bacterial evolution, but the specific rules that govern this transfer remain elusive. In this PLOS Biology issue, Haudiquet and colleagues revealed that the interactions between m
Externí odkaz:
https://doaj.org/article/2dc4f7298eb641a883de708e610e33d2
Autor:
Cristina Herencias, Jerónimo Rodríguez-Beltrán, Ricardo León-Sampedro, Aida Alonso-del Valle, Jana Palkovičová, Rafael Cantón, Álvaro San Millán
Publikováno v:
eLife, Vol 10 (2021)
Collateral sensitivity (CS) is a promising alternative approach to counteract the rising problem of antibiotic resistance (ABR). CS occurs when the acquisition of resistance to one antibiotic produces increased susceptibility to a second antibiotic.
Externí odkaz:
https://doaj.org/article/c2d0354829ac479db07608ff95e9568f