Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jerónimo Bravo"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Ribosome biogenesis is an emerging therapeutic target. It has been proposed that cancer cells are addicted to ribosome production which is therefore considered a druggable pathway in cancer therapy. Cancer cells have been shown to be more sensitive t
Externí odkaz:
https://doaj.org/article/a7274c2791f641d1937e34aff45e0610
Autor:
Jerónimo Bravo, José L. Neira
Publikováno v:
The Scientific World Journal, Vol 10, Pp 1612-1633 (2010)
Pancreatic cancer (PC) is one of the most difficult illnesses to treat, since the 5-year survival rate is lower than 5% in patients and no substantial advances in its treatment have been achieved in the last 20 years. Since cancer deregulation and pr
Externí odkaz:
https://doaj.org/article/a9df83d316ea49199435f328e5699647
Autor:
Jose L Ortega Roldan, Salvador Casares, Malene Ringkjøbing Jensen, Nayra Cárdenes, Jerónimo Bravo, Martin Blackledge, Ana I Azuaga, Nico A J van Nuland
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73018 (2013)
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 dom
Externí odkaz:
https://doaj.org/article/f0dfce6381094a71b4f4d8cd64cd8eef
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6433 (2009)
BACKGROUND:Breast cancer metastasis suppressor 1 (BRMS1) reduces the number and the size of secondary tumours in a mouse model without affecting the growth of the primary foci upon its re-expression. Knockdown of BRMS1 expression associates with meta
Externí odkaz:
https://doaj.org/article/82965e31731f4e079c285c80e6022120
Autor:
Jerónimo Bravo, Xiguang Zhang, Lu Tian, Angelita Rebollo, Sylvain Choquet, Etienne Waelkens, Veerle Janssens, Severine Loisel, Jesús Fominaya, Jean Marc Zini, Dorien Haesen
Publikováno v:
International Journal of Peptide Research and Therapeutics. 24:479-488
Protein phosphatase 2A (PP2A) is known to be a negative regulator of several survival and proliferating pathways that are frequently altered in cancer. In addition to chemical enzymatic inhibitors of the PP2A activity, the oncoprotein SET has been de
Autor:
Jerónimo Bravo, Magda Villarroya, Adrián Velázquez-Campoy, Rafael Ruiz-Partida, Silvia Prado, M-Eugenia Armengod
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
JOURNAL OF MOLECULAR BIOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Oberta de Catalunya (UOC)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
instname
JOURNAL OF MOLECULAR BIOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Oberta de Catalunya (UOC)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
21 páginas, 11 figuras, 4 tablas. Material suplementario en http://dx.doi.org/10.1016/j.jmb.2018.05.035
The Escherichia coli homodimeric proteins MnmE and MnmG form a functional complex, MnmEG, that modifies tRNAs using GTP, methylene-tetrahydr
The Escherichia coli homodimeric proteins MnmE and MnmG form a functional complex, MnmEG, that modifies tRNAs using GTP, methylene-tetrahydr
Autor:
M. Dolores Marcos, José Ramón Murguía, Leticia Dominguez-Berrocal, Jerónimo Bravo, Cristina de la Torre, Ramón Martínez-Máñez, Félix Sancenón
Publikováno v:
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
instname
[EN] Apoptotic signaling pathways are altered in numerous pathologies such as cancer. In this scenario, caspase-9/PP2Ac alpha interaction constitutes a key target with pharmacological interest to re-establish apoptosis in tumor cells. Very recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83d54202d9289e062a39f3605d48995
Publikováno v:
Nucleic Acids Research
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
14 páginas, 6 figuras.
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given the importance of this process in proliferating cells, it is obvious that understanding the macro
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given the importance of this process in proliferating cells, it is obvious that understanding the macro
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:684-687
Acidic leucine-rich nuclear phosphoprotein 32A (PP32A) is a tumour suppressor whose expression is altered in many cancers. It is an apoptotic enhancer that stimulates apoptosome-mediated caspase activation and also forms part of a complex involved in
Autor:
Jesús Ruiz-Cabello, Aránzazu Pintor-Chocano, Bárbara González-Terán, Guadalupe Sabio, Luis Leiva-Vega, Marcos Malumbres, Jerónimo Bravo, Juan A. Bernal, Marta Roche-Molina, Yulia A. Nevzorova, Nuria Matesanz, Hannah E. Mischo, Jesús Vázquez, Antonia Tomás-Loba, Ainoa Caballero, Valle Montalvo-Romeral, Miguel Marcos, Elisa Manieri, Beatriz Caballero, Ferran Feixas, Lourdes Hernández-Cosido, Marianna Trakala, Marta León, Rafael Romero-Becerra, Francisco Javier Cubero, Elena Rodríguez, Alfonso Mora, Oscar Blanco, Jorge L Torres, Juan Antonio López, Sílvia Osuna, Ayelén M Santamans, Diego Miranda-Saavedra
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Tomás-loba, A, Manieri, E, González-terán, B, Mora, A, Leiva-vega, L, Santamans, A M, Romero-becerra, R, Rodríguez, E, Pintor-chocano, A, Feixas, F, López, J A, Caballero, B, Trakala, M, Blanco, Ó, Torres, J L, Hernández-cosido, L, Montalvo-romeral, V, Matesanz, N, Roche-molina, M, Bernal, J A, Mischo, H, León, M, Caballero, A, Miranda-saavedra, D, Ruiz-cabello, J, Nevzorova, Y A, Cubero, F J, Bravo, J, Vázquez, J, Malumbres, M, Marcos, M, Osuna, S & Sabio, G 2019, ' p38γ is essential for cell cycle progression and liver tumorigenesis ', Nature, vol. 568, no. 7753, pp. 557-560 . https://doi.org/10.1038/s41586-019-1112-8
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Tomás-loba, A, Manieri, E, González-terán, B, Mora, A, Leiva-vega, L, Santamans, A M, Romero-becerra, R, Rodríguez, E, Pintor-chocano, A, Feixas, F, López, J A, Caballero, B, Trakala, M, Blanco, Ó, Torres, J L, Hernández-cosido, L, Montalvo-romeral, V, Matesanz, N, Roche-molina, M, Bernal, J A, Mischo, H, León, M, Caballero, A, Miranda-saavedra, D, Ruiz-cabello, J, Nevzorova, Y A, Cubero, F J, Bravo, J, Vázquez, J, Malumbres, M, Marcos, M, Osuna, S & Sabio, G 2019, ' p38γ is essential for cell cycle progression and liver tumorigenesis ', Nature, vol. 568, no. 7753, pp. 557-560 . https://doi.org/10.1038/s41586-019-1112-8
27 páginas, 4 figuras. Contiene material suplementario, método, 6 figuras en: https://doi.org/10.1038/s41586-019-1112-8
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin prot
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin prot