Suicide gene therapy by canine mesenchymal stem cell transduced with thymidine kinase in a u-87 glioblastoma murine model: Secretory profile and antitumor activity

Autor: Antonio J. Villatoro, Cristina Alcoholado, María del Carmen Martín-Astorga, Nuria Rubio, Jerónimo Blanco, Cristina Pilar Garrido, José Becerra

Publikováno v: PLoS ONE, Vol 17, Iss 2 (2022)

The role played by certain domestic species such as dogs as a translational model in comparative oncology shows great interest to develop new therapeutic strategies in brain tumors. Gliomas are a therapeutic challenge that represents the most common

Externí odkaz: https://doaj.org/article/d38f5ddf5ff84839a2d2407172ccee53

Application of an assay Cascade methodology for a deep preclinical characterization of polymeric nanoparticles as a treatment for gliomas

Autor: Cristina Fornaguera, Miguel Ángel Lázaro, Pau Brugada-Vilà, Irene Porcar, Ingrid Morera, Marta Guerra-Rebollo, Cristina Garrido, Núria Rubio, Jerónimo Blanco, Anna Cascante, Salvador Borrós

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 472-483 (2018)

Glioblastoma multiforme (GBM) is the most devastating primary brain tumor due to its infiltrating and diffuse growth characteristics, a situation compounded by the lack of effective treatments. Currently, many efforts are being devoted to find novel

Externí odkaz: https://doaj.org/article/af241c1d276f4c4fbc8482279955acb8

Polymeric Composite Dressings Containing Calcium-Releasing Nanoparticles Accelerate Wound Healing in Diabetic Mice

Autor: Jerónimo Blanco, Soledad Pérez-Amodio, Mercè Alsina-Giber, Elisabeth Engel, Claudia Navarro-Requena, Oscar Castaño, Joan Marti-Munoz, Aitor Sanchez-Ferrero, Olaia F. Vila, Nuria Rubio

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Adv Wound Care (New Rochelle)

[Objective] Wound healing is a complex process that involves the interaction between different cell types and bioactive factors. Impaired wound healing is characterized by a loss in synchronization of these interactions, resulting in nonhealing chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039bfc606108813eefd5ce9d39210ff
http://hdl.handle.net/10261/265594

Engineered microtissues for the bystander therapy against cancer

Autor: Gerard Rubí-Sans, Jerónimo Blanco, Nuria Rubio, Miguel A. Mateos-Timoneda, Irene Cano-Torres, Barbara Blanco-Fernandez, Elisabeth Engel, Marta Guerra-Rebollo, Lourdes Sánchez-Cid, Cristina Garrido, Soledad Pérez-Amodio

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74235a5c6ae872b5445eac2f56731a06
http://hdl.handle.net/2445/184321

Glioblastoma therapy with cytotoxic mesenchymal stromal cells optimized by bioluminescence imaging of tumor and therapeutic cell response.

Autor: Maria Alieva, Juli R Bagó, Elisabet Aguilar, Carolina Soler-Botija, Olaia F Vila, Joan Molet, Sanjiv S Gambhir, Nuria Rubio, Jerónimo Blanco

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35148 (2012)

Genetically modified adipose tissue derived mesenchymal stromal cells (hAMSCs) with tumor homing capacity have been proposed for localized therapy of chemo- and radiotherapy resistant glioblastomas. We demonstrate an effective procedure to optimize g

Externí odkaz: https://doaj.org/article/df3d4245eb274f3eaf487fa5f07d68e1