One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.

Autor: Jepps, TA¹, OlesEN, SP², GreENwood, IA¹

Publikováno v: British Journal of Pharmacology. Jan2013, Vol. 168 Issue 1, p19-27. 9p.

Molecular and functional characterization of Kv 7 channels in penile arteries and corpus cavernosum of healthy and metabolic syndrome rats

Autor: Jepps, TA, Olesen, SP, Greenwood, IA, Dalsgaard, T

BACKGROUND AND PURPOSE: KCNQ-encoded voltage-dependent potassium channels (Kv 7) are involved in the regulation of vascular tone. In this study we evaluated the influence of Kv 7 channel activation on smooth muscle relaxation in rat penile arteries a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a340ee98ee9bb1a8b5c1965ed29cba6d

Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension.

Autor: Chadha PS, Zunke F, Zhu HL, Davis AJ, Jepps TA, Olesen SP, Cole WC, Moffatt JD, Greenwood IA, Chadha, Preet S, Zunke, Friederike, Zhu, Hai-Lei, Davis, Alison J, Jepps, Thomas A, Olesen, Søren P, Cole, William C, Moffatt, James D, Greenwood, Iain A

Publikováno v: Hypertension (0194911X); Apr2012, Vol. 59 Issue 4, p877-884, 8p

Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation.

Autor: Forrester EA; Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George's University, Cranmer Terrace, London SW17 ORE, UK., Benítez-Angeles M; I Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico., Redford KE; Bioelectricity Lab, Department of Physiology & Biophysics, School of Medicine, University of California, Irvine, USA., Rosenbaum T; I Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico., Abbott GW; Bioelectricity Lab, Department of Physiology & Biophysics, School of Medicine, University of California, Irvine, USA., Barrese V; Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy., Dora K; Department of Pharmacology, Oxford University, Oxford, UK., Albert AP; Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George's University, Cranmer Terrace, London SW17 ORE, UK., Dannesboe J; Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Salles-Crawley I; Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George's University, Cranmer Terrace, London SW17 ORE, UK., Jepps TA; Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Greenwood IA; Vascular Biology Section, Molecular & Clinical Sciences Research Institute, St George's University, Cranmer Terrace, London SW17 ORE, UK.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2024 Nov 25; Vol. 120 (14), pp. 1811-1824.

Polymodal K ⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.

Autor: Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Yoshimura RF; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Yeromin AV; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Hogenkamp D; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., van der Horst J; Department of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Zavala A; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Chinedu S; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Arena G; Redwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA., Lasky E; Redwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA., Fisher M; Philip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA., Tracy CR; Philip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA., Othy S; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Jepps TA; Department of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Cahalan MD; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. abbottg@hs.uci.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Aug 28; Vol. 7 (1), pp. 1059. Date of Electronic Publication: 2024 Aug 28.