Extracellular vesicles and nanoparticles: emerging complexities.

Autor: Jeppesen DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zhang Q; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Franklin JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Coffey RJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: robert.coffey@vumc.org.

Publikováno v: Trends in cell biology [Trends Cell Biol] 2023 Aug; Vol. 33 (8), pp. 667-681. Date of Electronic Publication: 2023 Feb 01.

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.

Autor: Mateescu B; Brain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., Jones JC; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Alexander RP; Extracellular RNA Communication Consortium, Phoenix, AZ 85254, USA., Alsop E; Neurogenomics Division, TGen, Phoenix, AZ 85004, USA., An JY; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Asghari M; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., Boomgarden A; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA., Bouchareychas L; Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.; Northern California Institute for Research and Education, San Francisco, CA 94121, USA., Cayota A; Functional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.; University Hospital, Universidad de la República, Montevideo 11600, Uruguay., Chang HC; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Charest A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Chiu DT; Department of Chemistry and Bioengineering, University of Washington, Seattle, WA 98195, USA., Coffey RJ; Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA., Das S; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., De Hoff P; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA., deMello A; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., D'Souza-Schorey C; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA., Elashoff D; Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Eliato KR; Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Franklin JL; Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA., Galas DJ; Pacific Northwest Research Institute, Seattle, WA 98122, USA., Gerstein MB; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.; Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06520, USA.; Department of Computer Science, Yale University, New Haven, CT 06520, USA., Ghiran IH; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Go DB; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Gould S; Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA., Grogan TR; Department of Medicine Statistics Core, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA., Higginbotham JN; Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hladik F; Departments of Obstetrics and Gynecology, and Medicine, University of Washington, Seattle, WA, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Huang TJ; Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA., Huo X; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Hutchins E; Neurogenomics Division, TGen, Phoenix, AZ 85004, USA., Jeppesen DK; Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Jovanovic-Talisman T; Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Kim BYS; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kim S; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Kim KM; Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Kim Y; Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Kitchen RR; Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Knouse V; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., LaPlante EL; Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Lebrilla CB; Department of Chemistry, University of California, Davis, CA 95616, USA., Lee LJ; Department of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Lennon KM; Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Li G; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Li F; Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Li T; Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA., Liu T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA., Liu Z; Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA., Maddox AL; Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., McCarthy K; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Meechoovet B; Neurogenomics Division, TGen, Phoenix, AZ 85004, USA., Maniya N; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Meng Y; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., Milosavljevic A; Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Program in Quantitative and Computational Biosciences Baylor College of Medicine, Houston, TX 77030, USA., Min BH; Department of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea., Morey A; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA., Ng M; Northern California Institute for Research and Education, San Francisco, CA 94121, USA., Nolan J; Scintillon Institute, San Diego, CA, USA., De Oliveira Junior GP; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Paulaitis ME; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Phu TA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA., Raffai RL; Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.; Northern California Institute for Research and Education, San Francisco, CA 94121, USA.; Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA., Reátegui E; Department of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Roth ME; Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Routenberg DA; Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA., Rozowsky J; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA., Rufo J; Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA., Senapati S; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Shachar S; Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA., Sharma H; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Sood AK; Department of Gynecologic Oncology & Reproductive Medicine, University of Texas MD Aderson Cancer Center, Houston, TX 77030, USA., Stavrakis S; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., Stürchler A; Brain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland., Tewari M; Department of Internal Medicine, Hematology/Oncology Division, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA., Tosar JP; Functional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay.; Analytical Biochemistry Unit, School of Science, Universidad de la República, Montevideo 11400, Uruguay., Tucker-Schwartz AK; Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA., Turchinovich A; Cancer Genome Research (B063), German Cancer Research Center DKFZ, Heidelberg 69120, Germany.; Heidelberg Biolabs GmbH, Heidelberg 69120, Germany., Valkov N; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Van Keuren-Jensen K; Neurogenomics Division, TGen, Phoenix, AZ 85004, USA., Vickers KC; Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Vojtech L; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA., Vreeland WN; Bioprocess Measurement Group, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA., Wang C; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Wang K; Institute for Systems Biology, Seattle, WA 98109, USA., Wang Z; Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA., Welsh JA; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Witwer KW; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Wong DTW; Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA., Xia J; Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA., Xie YH; Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA., Yang K; Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA., Zaborowski MP; Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland., Zhang C; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA., Zhang Q; Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zivkovic AM; Department of Nutrition, University of California, Davis, CA 95616, USA., Laurent LC; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA.

Publikováno v: IScience [iScience] 2022 Jun 23; Vol. 25 (8), pp. 104653. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.

Autor: Zhang Q; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jeppesen DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Higginbotham JN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Graves-Deal R; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Trinh VQ; Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, TN, USA., Ramirez MA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Sohn Y; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Neininger AC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Taneja N; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., McKinley ET; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Niitsu H; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cao Z; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Evans R; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA., Glass SE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ray KC; Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, TN, USA., Fissell WH; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA., Hill S; Proteomics Laboratory, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Rose KL; Proteomics Laboratory, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA., Huh WJ; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Washington MK; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Ayers GD; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Burnette DT; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Sharma S; Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA.; California NanoSystems Institute, University of California at Los Angeles, Los Angeles, CA, USA., Rome LH; California NanoSystems Institute, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Franklin JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Lee YA; Section of Surgical Sciences, Vanderbilt University School of Medicine, Nashville, TN, USA., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Coffey RJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. robert.coffey@vumc.org.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. robert.coffey@vumc.org.

Publikováno v: Nature cell biology [Nat Cell Biol] 2021 Dec; Vol. 23 (12), pp. 1240-1254. Date of Electronic Publication: 2021 Dec 09.

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.

Autor: Hinger SA; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA., Abner JJ; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA., Franklin JL; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37235, USA., Jeppesen DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37235, USA., Coffey RJ; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37235, USA.; Veterans Affairs Medical Center, Nashville, TN, 37235, USA.; Vanderbilt University, Nashville, TN, 37235, USA., Patton JG; Department of Biological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235, USA. james.g.patton@vanderbilt.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Sep 25; Vol. 10 (1), pp. 15804. Date of Electronic Publication: 2020 Sep 25.

Reassessment of Exosome Composition.

Autor: Jeppesen DK; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Fenix AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Franklin JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Veterans Affairs Medical Center, Nashville, TN 37232, USA., Higginbotham JN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zhang Q; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Zimmerman LJ; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Liebler DC; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Ping J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Evans R; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Fissell WH; Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Patton JG; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA., Rome LH; Department of Biological Chemistry, David Geffen School of Medicine and the California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA 90095, USA., Burnette DT; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Coffey RJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Veterans Affairs Medical Center, Nashville, TN 37232, USA. Electronic address: robert.coffey@vumc.org.

Publikováno v: Cell [Cell] 2019 Apr 04; Vol. 177 (2), pp. 428-445.e18.