Cold acclimation increases depolarization resistance and tolerance in muscle fibers from a chill-susceptible insect

Autor: Jeppe Seamus, Bayley, Jesper Givskov, Sørensen, Martin, Moos, Vladimír, Koštál, Johannes, Overgaard

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 319(4)

Cold exposure depolarizes cells in insects due to a reduced electrogenic ion transport and a gradual increase in extracellular K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18432b6b0c23d7139b2b3a971e3f0ce1
https://pubmed.ncbi.nlm.nih.gov/32847398

Skeletal muscle dysfunction in the db/db mouse model of type 2 diabetes

Autor: Ole Bækgaard Nielsen, Jeppe Seamus Bayley, Thomas Holm Pedersen

Publikováno v: Muscle & Nerve. 54:460-468

Introduction In this study we examined the mechanisms of motor dysfunction in type 2 diabetes. Methods Contractile force was measured in isolated nerve–muscle preparations of db/db mice using various protocols for electrical stimulation. Sarcoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1f3a0c20b69033a317c9fad9e3e03e
https://doi.org/10.1002/mus.25064

Cold acclimation modulates voltage gated Ca 2+ channel currents and fiber excitability in skeletal muscles of Locusta migratoria

Autor: Jeppe Seamus Bayley, Johannes Overgaard, Thomas Holm Pedersen, Martin Johannesen Klepke

Publikováno v: Bayley, J S, Klepke, M J, Pedersen, T H & Overgaard, J 2019, ' Cold acclimation modulates voltage gated Ca 2+ channel currents and fiber excitability in skeletal muscles of Locusta migratoria ', Journal of Insect Physiology, vol. 114, pp. 116-124 . https://doi.org/10.1016/j.jinsphys.2019.03.003

Cold exposure is known to induce stressful imbalances in chill susceptible insects, including loss of hemolymph water, hyperkalemia and cell depolarization. Cold induced depolarization induces uncontrolled Ca 2+ influx and accumulation of injury thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48efecb90f7dc3c1d165029b5821a32
https://pure.au.dk/portal/da/publications/cold-acclimation-modulates-voltage-gated-ca-2-channel-currents-and-fiber-excitability-in-skeletal-muscles-of-locusta-migratoria(2741790e-8b4d-470b-a091-1e8db3a99a55).html

Cold exposure causes cell death by depolarization-mediated Ca2+ overload in a chill-susceptible insect

Autor: Camilla Grønkjær, Jeppe Seamus Bayley, Mads Kuhlmann Andersen, Christian Bak Winther, Johannes Overgaard, Ole Bækgaard Nielsen, Thomas Holm Pedersen

Publikováno v: Bayley, J S, Winther, C B, Andersen, M K, Grønkjær, C, Nielsen, O B, Pedersen, T H & Overgaard, J 2018, ' Cold exposure causes cell death by depolarization-mediated Ca2+ overload in a chill-susceptible insect ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 41, pp. E9737-E9744 . https://doi.org/10.1073/pnas.1813532115

Cold tolerance of insects is arguably among the most important traits defining their geographical distribution. Even so, very little is known regarding the causes of cold injury in this species-rich group. In many insects it has been observed that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3cbb35a3f5d31165c3f5b32699cf5c
https://pure.au.dk/portal/da/publications/cold-exposure-causes-cell-death-by-depolarizationmediated-ca2-overload-in-a-chillsusceptible-insect(4ba3c736-9abe-4dcb-b4cc-3a740adf4405).html