Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jeppe P. Ekberg"'
Autor:
Anna Sofie Husted, Jeppe H. Ekberg, Emma Tripp, Tinne A.D. Nissen, Stijn Meijnikman, Shannon L. O'Brien, Trond Ulven, Yair Acherman, Sjoerd C. Bruin, Max Nieuwdorp, Zach Gerhart-Hines, Davide Calebiro, Lars O. Dragsted, Thue W. Schwartz
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101103- (2020)
Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback regu
Externí odkaz:
https://doaj.org/article/dfb3bd9efe4a45b38a1d9a446ce4b2e5
Autor:
Thue W. Schwartz, Maja S. Engelstoft, Andreas N. Madsen, Pascal Timshel, Jeppe P. Ekberg, Maria Hauge
Publikováno v:
Molecular and Cellular Endocrinology. 449:64-73
GPR40 is generally known to signal through Gq. However, in transfected cells, certain synthetic agonists can make the receptor signal also through Gs and cAMP (Hauge et al., 2015). Here we find that, in colonic crypt cultures, the GLP-1 secretion ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f62573f3620dd2c248762fe3ab9576
https://doi.org/10.1016/j.mce.2016.11.024
https://doi.org/10.1016/j.mce.2016.11.024
Autor:
Maja S. Engelstoft, Jacek Mokrosinski, Alexander Munk, Natalia Petersen, Yue Feng, Fiona M. Gribble, Margaret Wu, Jens J. Holst, Jin Shang, Yun-Ping Zhou, Thue W. Schwartz, Andrew D. Howard, Jeppe P. Ekberg, Siv A. Hjorth, Jonas T. Treebak, Kristoffer L. Egerod, Frank Reimann, Jens F. Rehfeld, Olga Rudenko, Peter Thams
Publikováno v:
Rudenko, O, Shang, J, Munk, A, Ekberg, J P, Petersen, N, Engelstoft, M S, Egerod, K L, Hjorth, S A, Wu, M, Feng, Y, Zhou, Y-P, Mokrosinski, J, Thams, P, Reimann, F, Gribble, F, Rehfeld, J F, Holst, J J, Treebak, J T, Howard, A D & Schwartz, T W 2019, ' The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones ', Molecular Metabolism, vol. 19, pp. 49-64 . https://doi.org/10.1016/j.molmet.2018.10.012
OBJECTIVES: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear.METHODS AND RESULTS: We find that GPR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f1db027dfe484c01950af736ab3092
https://pubmed.ncbi.nlm.nih.gov/30472415
https://pubmed.ncbi.nlm.nih.gov/30472415
Autor:
Birgitte Holst, Jerry Di Salvo, Michael Lückmann, Marie A. Vestmar, Maja S. Engelstoft, Andrew D. Howard, Michael W. Miller, Thue W. Schwartz, Adam B. Weinglass, Thomas M. Frimurer, Andreas N. Madsen, Maria E. Trujillo, Michael Wright, Anna Sofie Husted, Jeppe P. Ekberg, Maria Hauge
Publikováno v:
Molecular Metabolism
Objectives GPR40 (FFAR1), a clinically proven anti-diabetes target, is a Gq-coupled receptor for long chain fatty acids (LCFA) stimulating insulin secretion directly and mediating a major part of the dietary triglyceride-induced secretion of the incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b5af997d5cc9813838fab22a527c11