Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia:The COVID STEROID randomised, placebo-controlled trial

Autor: Cecilie Bauer Derby, Henrik Nielsen, Anders Granholm, Theis Lange, Tine Sylvest Meyhoff, Trine Bak Jonassen, Lene Surland Knudsen, Balasubramanian Venkatesh, Mikkel Zacharias Bystrup Holst-Hansen, Jens S. Svenningsen, Jens Wolfgang Leistner, Lene Lund Andersen, Dalia Abou-Kassem, Marie Helleberg, Anders Pape Møller, Camilla Meno Kristensen, Rebecka Rubenson Wahlin, Mette Mindedahl Jespersen, Thomas Hildebrandt, Jens Laigaard, Johan Mikkelsen, Carl Johan Steensen Hjortsø, Niels Christian Haubjerg Østerby, Thomas Strøm, Boris Wied Tøstesen, Ali Al-Alak, Anne Sofie Andreasen, Vivekanand Jha, Birka Ravnholt Damlund, Stephan M. Jakob, Reem Zaabalawi, Lene Russell, Morten H. Bestle, Thomas Benfield, Esben Clapp, Caroline Løkke Bjerregaard, Christian Gluud, Anders Perner, Maria Cronhjort, Charlotte Suppli Ulrik, Vibe Sommer Mikkelsen, Signe Bjørn Laursen, Lone Musaeus Poulsen, Morten Hylander Møller, Peter Buhl Hjortrup, Christoffer Sølling, Vibeke Lind Jørgensen, Bodil Steen Rasmussen, Naomi E Hammond, Sheila Nainan Myatra, Emilie Kabel Madsen, Maj Brit Nørregaard Kjær, Gitte Kingo Vesterlund, Mathilde Languille Lassen, Emma Victoria Hatley, Marie Qvist Jensen, Marie Warrer Munch, Anders Hørby Rasmussen, Mik Wetterslev, Mathilde Lykke, Anne Craveiro Brøchner, Emil Arnerlöv, Steffen Christensen, Janne Schwab, Thomas Steen Jensen, Jeppe Lundholm Stadarfeld Jensen, Klaus Tjelle Kristiansen, Mohammed Mahmoud Daoud, Luca Cioccari, Suhayb Abdi, Kirstine la Cour, Nick Meier

Publikováno v: Munch, M W, Meyhoff, T S, Helleberg, M, Kjær, M B N, Granholm, A, Hjortsø, C J S, Jensen, T S, Møller, M H, Hjortrup, P B, Wetterslev, M, Vesterlund, G K, Russell, L, Jørgensen, V L, Kristiansen, K T, Benfield, T, Ulrik, C S, Andreasen, A S, Bestle, M H, Poulsen, L M, Hildebrandt, T, Knudsen, L S, Møller, A, Sølling, C G, Brøchner, A C, Rasmussen, B S, Nielsen, H, Christensen, S, Strøm, T, Cronhjort, M, Wahlin, R R, Jakob, S M, Cioccari, L, Venkatesh, B, Hammond, N, Jha, V, Myatra, S N, Jensen, M Q, Leistner, J W, Mikkelsen, V S, Svenningsen, J S, Laursen, S B, Hatley, E V, Kristensen, C M, Al-Alak, A, Clapp, E, Jonassen, T B, Bjerregaard, C L, Østerby, N C H, Jespersen, M M, Abou-Kassem, D, Lassen, M L, Zaabalawi, R, Daoud, M M, Abdi, S, Meier, N, la Cour, K, Derby, C B, Damlund, B R, Laigaard, J, Andersen, L L, Mikkelsen, J, Jensen, J L S, Rasmussen, A H, Arnerlöv, E, Lykke, M, Holst-Hansen, M Z B, Tøstesen, B W, Schwab, J, Madsen, E K, Gluud, C, Lange, T & Perner, A 2021, ' Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia : The COVID STEROID randomised, placebo-controlled trial ', Acta Anaesthesiologica Scandinavica, vol. 65, no. 10, pp. 1421-1430 . https://doi.org/10.1111/aas.13941
Munch, M W, Meyhoff, T S, Helleberg, M, Kjaer, M-B N, Granholm, A, Hjortsø, C J S, Jensen, T S, Møller, M H, Hjortrup, P B, Wetterslev, M, Vesterlund, G K, Russell, L, Jørgensen, V L, Tjelle Kristiansen, K, Benfield, T, Ulrik, C S, Andreasen, A S, Bestle, M H, Poulsen, L M, Hildebrandt, T, Knudsen, L S, Møller, A, Sølling, C G, Brøchner, A C, Rasmussen, B S, Nielsen, H, Christensen, S, Strøm, T, Cronhjort, M, Wahlin, R R, Jakob, S M, Cioccari, L, Venkatesh, B, Hammond, N, Jha, V, Myatra, S N, Jensen, M Q, Leistner, J W, Mikkelsen, V S, Svenningsen, J S, Laursen, S B, Hatley, E V, Kristensen, C M, Al-Alak, A, Clapp, E, Jonassen, T B, Bjerregaard, C L, Østerby, N C H, Jespersen, M M, Abou-Kassem, D, Lassen, M L, Zaabalawi, R, Daoud, M M, Abdi, S, Meier, N, la Cour, K, Derby, C B, Damlund, B R, Laigaard, J, Andersen, L L, Mikkelsen, J, Jensen, J L S, Rasmussen, A H, Arnerlöv, E, Lykke, M, Holst-Hansen, M Z B, Tøstesen, B W, Schwab, J, Madsen, E K, Gluud, C, Lange, T & Perner, A 2021, ' Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia : the COVID STEROID randomised, placebo-controlled trial ', Acta Anaesthesiologica Scandinavica . https://doi.org/10.1111/aas.13941
Acta Anaesthesiologica Scandinavica

BACKGROUND In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID-19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In th

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https://curis.ku.dk/ws/files/312772504/Low_dose_hydrocortisone_in_patients_with_COVID_19_and_severe_hypoxia.pdf