Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeppe Kejser Christensen"'
Publikováno v:
British Journal of Pharmacology. 168:2000-2010
Background and Purpose Strong implications in major neurological diseases make the neuronal α4β2 nicotinic ACh receptor (nAChR) a highly interesting drug target. In this study, we present a detailed electrophysiological characterization of NS9283,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c359ae431753a54cc4304d30decc975
https://doi.org/10.1111/bph.12095
https://doi.org/10.1111/bph.12095
Autor:
Morten Grunnet, Philip K. Ahring, Kathy L. Kohlhaas, Tino Dyhring, Dan Peters, Smith M, Jeppe Kejser Christensen, Sandager-Nielsen K, Jacobsen Am, E.Ø. Nielsen, Daniel B. Timmermann, Gunnar M. Olsen
Publikováno v:
British Journal of Pharmacology. 167:164-182
BACKGROUND AND PURPOSE Positive allosteric modulation of α4β2 nicotinic acetylcholine (nACh) receptors could add a new dimension to the pharmacology and therapeutic approach to these receptors. The novel modulator NS9283 was therefore tested extens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a25a324fd3d11c452c08ab3afdec5aba
https://doi.org/10.1111/j.1476-5381.2012.01989.x
https://doi.org/10.1111/j.1476-5381.2012.01989.x
Autor:
Bente Frølund, Camilla P. Hansen, Jeppe Kejser Christensen, Thomas Balle, Tommy Liljefors, Anders A. Jensen
Publikováno v:
Journal of Medicinal Chemistry. 51:7380-7395
A series of carbamoylcholine and acetylcholine analogues were synthesized and characterized pharmacologically at neuronal nicotinic acetylcholine receptors (nAChRs). Several of the compounds displayed low nanomolar binding affinities to the alpha4bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ceb3573a3b734aaba741e3abd46cc73
https://doi.org/10.1021/jm701625v
https://doi.org/10.1021/jm701625v
Autor:
Eva Dam, Philip K. Ahring, Tino Dyhring, Helle K. Erichsen, Joachim Demnitz, Jeppe Kejser Christensen, Gordon Munro
Summary Aims Here, we investigate the pharmacology of NS383, a novel small molecule inhibitor of acid-sensing ion channels (ASICs). Methods ASIC inhibition by NS383 was characterized in patch-clamp electrophysiological studies. Analgesic properties w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd01958a7734bbd9ffdcd91fa7625ad
https://europepmc.org/articles/PMC6492852/
https://europepmc.org/articles/PMC6492852/
Autor:
Jeppe Kejser Christensen, Elsebet Ø. Nielsen, Dan Peters, Gunnar M. Olsen, Jesper T. Andreasen, John Paul Redrobe
Publikováno v:
Neuropharmacology. 73
As affective and cognitive disturbances frequently co-occur in psychiatric disorders, research into opportunities to simultaneously target both entities is warranted. These disorders are typically treated with monoamine reuptake inhibitors (MRIs), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2d22ba252c38c075445fc0f1e62c6c
https://pubmed.ncbi.nlm.nih.gov/23748055
https://pubmed.ncbi.nlm.nih.gov/23748055
Autor:
Marianne L. Jensen, Philip K. Ahring, Jeppe Kejser Christensen, Kasper Harpsøe, Thomas Balle, Dan Peters
The neuronal α4β2 nicotinic acetylcholine receptors exist as two distinct subtypes, (α4)(2)(β2)(3) and (α4)(3)(β2)(2), and biphasic responses to acetylcholine and other agonists have been ascribed previously to coexistence of these two receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d0825c159158966bf170168cfee973
https://europepmc.org/articles/PMC6623092/
https://europepmc.org/articles/PMC6623092/
Autor:
John Paul Redrobe, Jesper T. Andreasen, Dan Peters, Jeppe Kejser Christensen, Elsebet Ø. Nielsen, Gunnar M. Olsen, Naheed R. Mirza
Publikováno v:
Journal of psychopharmacology (Oxford, England). 25(10)
Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. Accordingly, nicotine enhances antidepressant-like actions of reuptake inhibitors selective for serotonin or noradrenaline in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77200bb8d539709b75403912245ecd6
https://pubmed.ncbi.nlm.nih.gov/20360159
https://pubmed.ncbi.nlm.nih.gov/20360159
Autor:
John Paul Redrobe, Jeppe Kejser Christensen, Elsebet Ø. Nielsen, Daniel B. Timmermann, Gunnar M. Olsen, Dan Peters
Publikováno v:
European journal of pharmacology. 602(1)
The alpha7 (alpha7) nicotinic acetylcholine receptor may represent a drug target for the treatment of disorders associated with working memory/attentional dysfunction. We investigated the effects of three distinct alpha7 nicotinic acetylcholine recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0677144600085ce0af0a2ff7d78c6842
https://pubmed.ncbi.nlm.nih.gov/18848931
https://pubmed.ncbi.nlm.nih.gov/18848931
Autor:
Egeria Guarino, Stefania Butini, Salvatore Sanna Coccone, Elena Morelli, Meri De Angelis, Arne Schousboe, Isabella Fiorini, Sandra Gemma, Jeppe Kejser Christensen, Francesco Trotta, Giuseppe Campiani, Darryl S. Pickering, Ettore Novellino
(S)-CPW399 ((S)-1) is a potent and excitotoxic AMPA receptor partial agonist. Modifying the cyclopentane ring of (S)-1, we developed two of the most potent and selective functional antagonists (5 and 7) for kainate receptor (KA-R) subunit iGluR5. Der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acc51d87e880d482f6c5ee244a10a44
http://hdl.handle.net/11588/333684
http://hdl.handle.net/11588/333684
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
8 páginas, 7 figuras.
Although some physiological functions of kainate receptors (KARs) still remain unclear, recent advances have highlighted a role in synaptic physiology. In hippocampal slices, kainate depresses GABA-mediated synaptic inhibi
Although some physiological functions of kainate receptors (KARs) still remain unclear, recent advances have highlighted a role in synaptic physiology. In hippocampal slices, kainate depresses GABA-mediated synaptic inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ada1b4289fb1f56d78096ea4102aa7a
https://pubmed.ncbi.nlm.nih.gov/15483117
https://pubmed.ncbi.nlm.nih.gov/15483117