Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeppe Egedal Kirchhoff"'
Autor:
Jonas Goldin Diness, Jeppe Egedal Kirchhoff, Tobias Speerschneider, Lea Abildgaard, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsTo describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant
Externí odkaz:
https://doaj.org/article/5c0147df7d244338b19b09ac7b4cb339
Autor:
Jeppe Egedal Kirchhoff, Mark Alexander Skarsfeldt, Kalai Mangai Muthukumarasamy, Rafel Simó-Vicens, Sofia Hammami Bomholtz, Lea Abildgaard, Thomas Jespersen, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IK
Externí odkaz:
https://doaj.org/article/0dc2f2226e674b7996e9529f482bfbcc
Autor:
Jonas Goldin, Diness, Jeppe Egedal, Kirchhoff, Tobias, Speerschneider, Lea, Abildgaard, Nils, Edvardsson, Ulrik S, Sørensen, Morten, Grunnet, Bo Hjorth, Bentzen
Publikováno v:
Frontiers in Pharmacology
Aims To describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistan
Autor:
Tobias Speerschneider, Rafel Simó-Vicens, Bo Hjorth Bentzen, Jonas Goldin Diness, Bernardo Dolce, Morten Grunnet, Jeppe Egedal Kirchhoff, Lea Abildgaard, Ulrik Svane Sørensen
Publikováno v:
British Journal of Pharmacology. 174:4396-4408
Background and Purpose Small conductance calcium-activated potassium (KCa2) channels represent a promising atrial-selective target for treatment of atrial fibrillation. Here, we establish the mechanism of KCa2 channel inhibition by the new compound A
Autor:
Thomas Jespersen, Morten Grunnet, Majid Sheykhzade, Jeppe Egedal Kirchhoff, Lea Abildgaard, Jonas Goldin Diness
Publikováno v:
Pflugers Archiv
Kirchhoff, J E, Diness, J G, Abildgaard, L, Sheykhzade, M, Grunnet, M & Jespersen, T 2016, ' Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation ', Pfluegers Archiv, vol. 468, no. 11, pp. 1853–1863 . https://doi.org/10.1007/s00424-016-1883-9
Kirchhoff, J E, Diness, J G, Abildgaard, L, Sheykhzade, M, Grunnet, M & Jespersen, T 2016, ' Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation ', Pfluegers Archiv, vol. 468, no. 11, pp. 1853–1863 . https://doi.org/10.1007/s00424-016-1883-9
Dose is an important parameter in terms of both efficacy and adverse effects in pharmacological treatment of atrial fibrillation (AF). Both of the class III antiarrhythmics dofetilide and amiodarone have documented anti-AF effects. While dofetilide h
Autor:
Jeppe Egedal, Kirchhoff, Mark Alexander, Skarsfeldt, Kalai Mangai, Muthukumarasamy, Rafel, Simó-Vicens, Sofia Hammami, Bomholtz, Lea, Abildgaard, Thomas, Jespersen, Ulrik S, Sørensen, Morten, Grunnet, Bo Hjorth, Bentzen, Jonas Goldin, Diness
Publikováno v:
Frontiers in Pharmacology
Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (IKr) is inhibited. The current mediated by KCa2-channels, IK
Autor:
Majid Sheykhzade, Morten Grunnet, Jeppe Egedal Kirchhoff, Jonas Goldin Diness, Thomas Jespersen
Publikováno v:
Journal of Cardiovascular Pharmacology. 66:294-299
During recent years, small conductance Ca-activated K (SK) channels have been reported to play a role in cardiac electrophysiology. SK channels seem to be expressed in atria and ventricles, but from a functional perspective, atrial activity is predom
Autor:
Thomas Jespersen, Morten Grunnet, Jeppe Egedal Kirchhoff, Jonas Goldin Diness, Majid Sheykhzade
Publikováno v:
Heart Rhythm. 12:409-418
Background Application of antiarrhythmic compounds is limited by both proarrhythmic and extracardiac toxicities, as well as incomplete antiarrhythmic efficacy. An improved antiarrhythmic potential may be obtained by combining antiarrhythmic drugs wit
Autor:
Jeppe Egedal, Kirchhoff, Jonas Goldin, Diness, Majid, Sheykhzade, Morten, Grunnet, Thomas, Jespersen
Publikováno v:
Heart rhythm. 12(2)
Application of antiarrhythmic compounds is limited by both proarrhythmic and extracardiac toxicities, as well as incomplete antiarrhythmic efficacy. An improved antiarrhythmic potential may be obtained by combining antiarrhythmic drugs with different