Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeongsup Shim"'
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1245-1253 (2019)
T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit patients’ T cells to kill cancer cells. There are many TDBs in clinical trials, demonstrating their widely recognized therapeutic potential. However, th
Externí odkaz:
https://doaj.org/article/24baf0511d5140e6b4f811d725bf2025
Autor:
Bingchuan Wei, Xuan Gao, Lance Cadang, Saeed Izadi, Peilu Liu, Hui-Min Zhang, Elizabeth Hecht, Jeongsup Shim, Gordon Magill, Juan Rincon Pabon, Lu Dai, Wilson Phung, Elaine Lin, Christopher Wang, Kevin Whang, Sean Sanchez, Jose Oropeza Jr, Julien Camperi, Jennifer Zhang, Wendy Sandoval, Yonghua Taylor Zhang, Guoying Jiang
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation betwee
Externí odkaz:
https://doaj.org/article/bdd3b615610e438ebfe86ec19cb0df05
Publikováno v:
mAbs
T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit patients’ T cells to kill cancer cells. There are many TDBs in clinical trials, demonstrating their widely recognized therapeutic potential. However, th
Autor:
Juan Pablo Rincon Pabon, Jennifer Zhang, Peilu Liu, Saeed Izadi, Lu Dai, Guoying Jiang, Yonghua Taylor Zhang, Julien Camperi, Wendy Sandoval, Gordon Magill, Sean Sanchez, Hui-Min Zhang, Xuan Gao, Jose Oropeza, Elaine Lin, Elizabeth S. Hecht, Bingchuan Wei, Lance Cadang, Kevin Whang, Christopher Wang, Jeongsup Shim, Wilson Phung
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation betwee
Autor:
Benjamin Haley, Cynthia Lam, Brett Marshall, Danming Tang, John B. Lowe, Jeongsup Shim, Shahram Misaghi, Bronislawa Petryniak, Brad Snedecor, Mandy Yim, Martina Brozynski, Amy Heidersbach, Salina Louie, David E. Shaw, Aaron Miller
Publikováno v:
Biotechnology and Bioengineering. 114:632-644
During antibody dependent cell cytotoxicity (ADCC) the target cells are killed by monocytes and natural killer cells. ADCC is enhanced when the antibody heavy chain's core N-linked glycan lacks the fucose molecule(s). Several strategies have been uti
Autor:
Yiwei Wang, Alex Yee-Chen Huang, Peter Qiao, Lan Zhou, Jeongsup Shim, Jay Myers, Grant Zimmerman, Dan Huang, John B. Lowe, David T. Scadden, Weihuan Wang, Vionnie W.C. Yu, Yuanshuai Huang, Pamela Stanley, William W. Xin, Wei Xin, Minhong Yan, Xiaoran Huang, Shuiliang Yu, Christian W. Siebel
Publikováno v:
Stem Cells. 33:2280-2293
Notch is long recognized as a signaling molecule important for stem cell self-renewal and fate determination. Here, we reveal a novel adhesive role of Notch-ligand engagement in hematopoietic stem and progenitor cells (HSPCs). Using mice with conditi
Publikováno v:
Journal of immunological methods. 448
Drozitumab is an agonistic therapeutic monoclonal antibody (mAb) against the pro-apoptotic death receptor 5 (DR5). In vitro cell killing assays using drozitumab have traditionally required cross-linking with anti-Fc antibody to amplify the pro-apopto
Autor:
Salina, Louie, Benjamin, Haley, Brett, Marshall, Amy, Heidersbach, Mandy, Yim, Martina, Brozynski, Danming, Tang, Cynthia, Lam, Bronislawa, Petryniak, David, Shaw, Jeongsup, Shim, Aaron, Miller, John B, Lowe, Brad, Snedecor, Shahram, Misaghi
Publikováno v:
Biotechnology and bioengineering. 114(3)
During antibody dependent cell cytotoxicity (ADCC) the target cells are killed by monocytes and natural killer cells. ADCC is enhanced when the antibody heavy chain's core N-linked glycan lacks the fucose molecule(s). Several strategies have been uti
Autor:
Lebing Wei Li, Yunfang Man, Bronisilawa Petryniak, Stephanie M. Chervin, Quanjian Yan, Lan Zhou, John B. Lowe, Charles A. Su, Jeongsup Shim
Publikováno v:
Blood. 112:308-319
Cell-cell contact–dependent mechanisms that modulate proliferation and/or differentiation in the context of hematopoiesis include mechanisms characteristic of the interactions between members of the Notch family of signal transduction molecules and
Autor:
Portia R. Peters, Shuichi Takayama, Jeongsup Shim, Marie Csete, Xiaoyue Zhu, Keiji Naruse, Joong Hwan Bahng, Elizabeth Ho Liu, M.D. Thouless, Kristen L. Mills
Publikováno v:
Nature Materials. 4:403-406
The interface between extracellular matrices and cells is a dynamic environment that is crucial for regulating important cellular processes such as signal transduction, growth, differentiation, motility and apoptosis1. In vitro cellular studies and t