Výsledky vyhledávání

Molecular Structural Evolution of Near-Infrared Cationic Aggregation-Induced Emission Luminogens: Preclinical Antimicrobial Pathogens Activities and Tissues Regeneration

Autor: Heejeong Kim, Jingjing Han, Dayeh Kim, Jeongsun Ha, Liuwei Zhang, Juyoung Yoon, Haidong Li, Jingyun Wang

Publikováno v: CCS Chemistry. 4:487-500

Increasingly infectious diseases from microbial pathogens (including bacteria and fungi) threaten human health: a situation that has aroused public health concern around the world. Unfortunately, b...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::173bc34e15d1af570fe1c2d07f611409
https://doi.org/10.31635/ccschem.021.202101206

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A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near N-methyl-d-aspartate (NMDA) receptors

Autor: Nahyun Kwon, Chang Su Lim, Dayoung Lee, Gyeongju Ko, Jeongsun Ha, Moonyeon Cho, K. M. K. Swamy, Eun-Young Lee, Dong Joon Lee, Sang-Jip Nam, Xin Zhou, Hwan Myung Kim, Juyoung Yoon

Publikováno v: Chemical Communications. 58:3633-3636

In this article, we report coumarin derivative 1 bearing cyanoacrylamide and ifenprodil moieties as the first reversible fluorescent probe that can monitor GSH near NMDA receptors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6773b8b75e232fd5c14f9d378dcb25f
https://doi.org/10.1039/d1cc05512g

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Fluorescence Probe for Imaging N-Methyl-d-aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy

Autor: Juyoung Yoon, Hwan Myung Kim, Nahyun Kwon, Jun Yin, Jeongsun Ha, Chang Su Lim, Dayoung Lee, Gyeongju Ko

Publikováno v: Analytical Chemistry. 93:11612-11616

N-Methyl-d-aspartate (NMDA) is an excitotoxic amino acid used to identify a specific subset of glutamate receptors. The activity of NMDA receptors is closely related to the redox level of the biological system. Glutathione (GSH) as an antioxidant pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::279feb7a4b174f5b3cdb53571eb44b88
https://doi.org/10.1021/acs.analchem.1c02350

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Rational Molecular Design of Efficient Heavy-Atom-Free Photosensitizers for Cancer Photodynamic Therapy

Autor: Van‐Nghia Nguyen, Jeongsun Ha, Hyunsun Jeong, Moonyeon Cho, Gyongmi Kim, Juyoung Yoon

Publikováno v: ChemPlusChem. 87(7)

Photodynamic therapy has emerged as a promising modality for treatment of cancer due to its minimal invasiveness and high selectivity. However, development of advanced photosensitizers (PSs) for clinical translation of photodynamic therapy remains ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11405afeeb74e05053ca228e71132d22
https://pubmed.ncbi.nlm.nih.gov/35502845

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Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer

Autor: Juyoung Yoon, Sang Jun Park, Dong Joon Lee, Gain Baek, Chang Su Lim, Hwan Myung Kim, Van-Nghia Nguyen, Sujie Qi, Seonye Heo, Yubin Yim, Jeongsun Ha

Publikováno v: Chemical Communications. 56:11489-11492

Novel thiocarbonyl derivatives (NIS and CRNS) with excellent ROS generation abilities are synthesized and studied as potential photosensitizers for one- and two-photon excited photodynamic therapy. In particular, NIS-Me and CRNS display outstanding p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11e63bd15c4c8113cb706f2aa3be3e4
https://doi.org/10.1039/d0cc04644b

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Reactivity Differences Enable ROS for Selective Ablation of Bacteria

Autor: Xiaofeng Wu, Mengyao Yang, Ji Seon Kim, Rui Wang, Gyoungmi Kim, Jeongsun Ha, Heejeong Kim, Yejin Cho, Ki Taek Nam, Juyoung Yoon

Publikováno v: Angewandte Chemie (International ed. in English). 61(17)

An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a59a2c5f470925b2adf47d2cf5e3a2
https://pubmed.ncbi.nlm.nih.gov/35174598

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Structure-oriented design strategy to construct NIR AIEgens to selectively combat gram (+) multidrug-resistant bacteria in vivo

Autor: Haidong Li, Mengyao Yang, Ji Seon Kim, Jeongsun Ha, Jingjing Han, Heejeong Kim, Yejin Cho, Jingyun Wang, Ki Taek Nam, Juyoung Yoon

Publikováno v: Biomaterials. 286:121580

Multidrug-resistant (MDR) gram-positive bacteria are an inevitable source of infection for hospitalized patients and one of the reasons for the increased proportion of severe diseases. Therefore, constructing smart agents for specific and effective c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da60543651a56ecd625c517362ba6d8
https://doi.org/10.1016/j.biomaterials.2022.121580

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Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis

Autor: Juyoung Yoon, Van-Nghia Nguyen, Moonyeon Cho, Haidong Li, Jeongsun Ha, K.M.K. Swamy

Publikováno v: Coordination Chemistry Reviews. 439:213936

Boron-dipyrromethene (BODIPY) platforms have been recognized as potential candidates for a wide range of applications, especially for constructing fluorescent probes due to their unique photophysical properties, outstanding photo- and chemical stabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ccf3a71ae56e44dd5cdad6990152941
https://doi.org/10.1016/j.ccr.2021.213936

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