Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jeongsik Yong"'
Autor:
Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 10, Pp 2145-2161 (2024)
Abstract Alternative cleavage and polyadenylation within introns (intronic APA) generate shorter mRNA isoforms; however, their physiological significance remains elusive. In this study, we developed a comprehensive workflow to analyze intronic APA pr
Externí odkaz:
https://doaj.org/article/827be614bc174acd9275265f854cc847
Autor:
Jeongsik Yong, Juhyun Song
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116688- (2024)
Metabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive fat accumulation and dyslipidemia, and is known to be accompanied by neuropathological symptoms such as memory loss, anxiety, and depression. As the number of
Externí odkaz:
https://doaj.org/article/d41244bb709a4af387d9d97a96014f83
Autor:
Lauren J. Sundby, William M. Southern, Jiao Sun, Xiaobai Patrinostro, Wei Zhang, Jeongsik Yong, James M. Ervasti
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151397- (2024)
The cytoplasmic actin proteins, β- and γ-actin, are 99% identical but thought to perform non-redundant functions. The nucleotide coding regions of cytoplasmic actin genes, Actb and Actg1, are 89% identical. Knockout (KO) of Actb by Cre-mediated del
Externí odkaz:
https://doaj.org/article/213c04ad534c416084dde9f9fa09cb67
Autor:
Naima Ahmed Fahmi, Khandakar Tanvir Ahmed, Jae-Woong Chang, Heba Nassereddeen, Deliang Fan, Jeongsik Yong, Wei Zhang
Publikováno v:
BMC Bioinformatics, Vol 23, Iss S3, Pp 1-14 (2022)
Abstract Background The eukaryotic genome is capable of producing multiple isoforms from a gene by alternative polyadenylation (APA) during pre-mRNA processing. APA in the 3′-untranslated region (3′-UTR) of mRNA produces transcripts with shorter
Externí odkaz:
https://doaj.org/article/73aa49f2544e4f40a4dc1ad28ac37c2c
Autor:
Wei Zhang, Raphael Petegrosso, Jae-Woong Chang, Jiao Sun, Jeongsik Yong, Jeremy Chien, Rui Kuang
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is necessary to accurately measure iso
Externí odkaz:
https://doaj.org/article/e573e790ac5349d7a120885e27090456
Autor:
Hsin-Sung Yeh, Jeongsik Yong
Publikováno v:
Journal of Lipid and Atherosclerosis, Vol 9, Iss 1, Pp 8-22 (2020)
Post-transcriptional regulations of mRNA transcripts such as alternative splicing and alternative polyadenylation can affect the expression of genes without changing the transcript levels. Recent studies have demonstrated that these post-transcriptio
Externí odkaz:
https://doaj.org/article/793500c1d02849468be614c079e7cb85
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008218 (2021)
High-throughput spatial-transcriptomics RNA sequencing (sptRNA-seq) based on in-situ capturing technologies has recently been developed to spatially resolve transcriptome-wide mRNA expressions mapped to the captured locations in a tissue sample. Due
Externí odkaz:
https://doaj.org/article/5bd80c885b06466ca0a597303b4e7c09
Autor:
Diako Ebrahimi, Christopher M. Richards, Michael A. Carpenter, Jiayi Wang, Terumasa Ikeda, Jordan T. Becker, Adam Z. Cheng, Jennifer L. McCann, Nadine M. Shaban, Daniel J. Salamango, Gabriel J. Starrett, Jairam R. Lingappa, Jeongsik Yong, William L. Brown, Reuben S. Harris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human APOBEC3H has several haplotypes and splice variants with distinct anti-HIV-1 activities, but the genetics underlying the expression of these variants are unclear. Here, the authors identify an intronic deletion in A3H haplotype II resulting in
Externí odkaz:
https://doaj.org/article/ea3b48a2ed974a7c8e6b38190a93470e
Publikováno v:
Endocrinology and Metabolism, Vol 32, Iss 4, Pp 413-421 (2017)
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene
Externí odkaz:
https://doaj.org/article/3fd37ec5fbe04a9e8759001f013fbb82
Publikováno v:
npj Precision Oncology, Vol 1, Iss 1, Pp 1-15 (2017)
Abstract Network-based analytics plays an increasingly important role in precision oncology. Growing evidence in recent studies suggests that cancer can be better understood through mutated or dysregulated pathways or networks rather than individual
Externí odkaz:
https://doaj.org/article/1f00df00fc5746258cca79b4f42f264e