Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jeonghoon Sun"'
Autor:
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Todd Hager, Junming Yie, Wei Wang, Dwight Winters, Stephen Smith, Chris Spahr, Lei-Ting Tam, Zhongnan Shen, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Lau, Allen Sickmier, Mark Leo Michaels, Thomas Boone, Murielle M Véniant, Jing Xu
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49345 (2012)
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2 diabetes. However, the use of wild type native FGF21 is challenging due to several limitations. Among these are its short half-life, its susceptibility to i
Externí odkaz:
https://doaj.org/article/4b03784bd0594b29a2d0316fd49362ba
Autor:
Douglas D, Banks, Jon F, Cordia, Vladimir, Spasojevic, Jeonghoon, Sun, Sarah, Franc, Younhee, Cho
Publikováno v:
Protein science : a publication of the Protein Society. 27(12)
Inert co‐solutes, or excipients, are often included in protein biologic formulations to adjust the tonicity of liquid dosage forms intended for subcutaneous delivery. Despite the low concentration of their use, many of these excipients alter protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9590157ab9de7d352e688cba79407f1
https://pubmed.ncbi.nlm.nih.gov/30267438
https://pubmed.ncbi.nlm.nih.gov/30267438
Autor:
Marc W. Retter, Mark Leo Michaels, Derek E. Piper, Katherine C Matsuda, Lei Zhou, Chadwick T. King, Wei Wang, Higbee Jared Martin, Jeonghoon Sun, Howard Monique L, Simon Jackson, Ren Xu, Randal R. Ketchem, Brandon Ason, Jie Tang, Kirk Henne, Joyce Chi Yee Chan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 353(1)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as an attractive therapeutic target for cardiovascular disease. Monoclonal antibodies (mAbs) that bind PCSK9 and prevent PCSK9:low-density lipoprotein receptor complex formation reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f51d0f83b17b3574d22d7dc84b3f51
https://pubmed.ncbi.nlm.nih.gov/25653417
https://pubmed.ncbi.nlm.nih.gov/25653417
Autor:
Jeonghoon Sun, Tae Woo Kwon, Demetri Theodore Moustakas, Jang H. Han, Mi Young Seo, Hui-hua Lu, Jong Won Kim, Anang A. Shelat, Chon Saeng Kim
Publikováno v:
Journal of Virology. 77:571-582
Hepatitis C virus (HCV) is a positive-strand RNA virus that encodes a helicase required for viral replication. Although HCV does not replicate through a DNA intermediate, HCV helicase unwinds both RNA and DNA duplexes. An X-ray crystal structure of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021ca45c381056ab46b8d7af6268a33f
https://doi.org/10.1128/jvi.77.1.571-582.2003
https://doi.org/10.1128/jvi.77.1.571-582.2003
Publikováno v:
Journal of Molecular Biology. 307:1103-1112
We have determined the sequence requirements for the N-terminal protein hinge of the active-site lid of triosephosphate isomerase. The codons for the hinge (PVW) were replaced with a genetic library of all possible 8000 amino acid combinations. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c305a43e6af18deadbc3e5d4cd076b
https://doi.org/10.1006/jmbi.2001.4536
https://doi.org/10.1006/jmbi.2001.4536
Autor:
Nicole S. Sampson, Jeonghoon Sun
Publikováno v:
Biochemistry. 38:11474-11481
In previous work we tested what three amino acid sequences could serve as a protein hinge in triosephosphate isomerase [Sun, J., and Sampson, N. S. (1998) Protein Sci. 7, 1495-1505]. We generated a genetic library encoding all 8000 possible 3 amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303dcc6ef82ec5583e2fef7014b7bdea
https://doi.org/10.1021/bi990862g
https://doi.org/10.1021/bi990862g
Autor:
Nicole S. Sampson, Jeonghoon Sun
Publikováno v:
Protein Science. 7:1495-1505
We have determined the sequence requirements for a protein hinge in triosephosphate isomerase. The codons encoding the hinge at the C-terminus of the active-site lid of triosephosphate isomerase were replaced with a genetic library of all possible 8,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f503af6e40f612ce58e04e3762d4708
https://doi.org/10.1002/pro.5560070702
https://doi.org/10.1002/pro.5560070702
Publikováno v:
Biochemistry. 35:12788-12795
The proximal iron ligand in horseradish peroxidase (HRP) is His-170. The H170A mutant of polyhistidine-tagged HRP (hHRP) has been expressed in a baculovirus system and has been purified and characterized. At pH 7, the Soret maximum of the mutant is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dabaff2588977d6f32feb7d9000ff9
https://doi.org/10.1021/bi9609331
https://doi.org/10.1021/bi9609331
Autor:
Wei Wang, E. Allen Sickmier, Yvonne Y. Lau, Lei-Ting Tam, Jeonghoon Sun, Zhongnan Shen, Murielle M. Véniant, Randy Ira Hecht, Chris Spahr, Dwight Winters, Jing Xu, Ed Belouski, Michael Hall, Shanaka Stanislaus, Junming Yie, Mark Leo Michaels, Yue-Sheng Li, Narumol Chinookoswong, Stephen Smith, Todd Hager, Thomas C. Boone
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e49345 (2012)
PLoS ONE, Vol 7, Iss 11, p e49345 (2012)
Fibroblast growth factor 21 (FGF21) is a promising drug candidate for the treatment of type 2 diabetes. However, the use of wild type native FGF21 is challenging due to several limitations. Among these are its short half-life, its susceptibility to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3e4149650061ef6c2e0155e5401e81
http://europepmc.org/articles/PMC3507880
http://europepmc.org/articles/PMC3507880
The Mechanism of Inhibition of Antibody-Based Inhibitors of Membrane-Type Serine Protease 1 (MT-SP1)
The mechanisms of inhibition of two novel scFv antibody inhibitors of the serine protease MT-SP1/matriptase reveal the basis of their potency and specificity. Kinetic experiments characterize the inhibitors as extremely potent inhibitors with K(I) va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0254ba8047c839f6ed175d9fd36c7a9d
https://europepmc.org/articles/PMC2041882/
https://europepmc.org/articles/PMC2041882/
