Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jeongbeob, Seo"'
Autor:
Byung-Nam Kang, Hong-Jun Kang, Sunjoo Kim, Jungwoo Lee, Jinwoo Lee, Hee-Jin Jeong, Seeun Jeon, Youngdo Shin, Cheolhwan Yoon, Cheolkyu Han, Jeongbeob Seo, Jaesook Yun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 85:129205
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
Metastatic breast cancers are aggressive tumors associated with high levels of epithelial-mesenchymal transition (EMT) markers, activation of IL6/JAK2/STAT3 and PI3K/AKT pathways for cell growth, mobility, invasion, metastasis, and CSC status. We ide
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
Autor:
Juhyun Moon, Gilnam Lee, Suk Young Cho, Yunsuk Choi, Jene Choi, Choung-Soo Kim, Sang-Hwa Yang, Kyun-Seop Bae, Jeongbeob Seo, Je-Hwan Lee, Bon-Kwan Goo, Jung Jin Hwang, Eun-Hye Hur
Publikováno v:
Oncotarget
Primary or acquired resistance to MEK inhibitors has been a barrier to successful treatment with MEK inhibitors in many tumors. In this study, we analyzed genome-wide gene expression profiling data from 6 sensitive and 6 resistant cell lines to ident
Autor:
Suk Young Cho, Woori Jo, Young Hee Yoon, Gilnam Lee, Eun Kyung Choi, Jung Jin Hwang, Hyun-Ji Choi, Bongcheol Kim, Woo-Chan Son, Joo Yong Lee, Hyun-Kyu Park, Jeongbeob Seo, Choung-Soo Kim
Publikováno v:
Journal of Applied Toxicology. 35:199-204
Many systemic drugs can induce ocular toxicity and several ocular side-effects have been identified in clinical studies. However, it is difficult to detect ocular toxicity in preclinical studies because of the lack of appropriate evaluation methods.
Publikováno v:
Scientific Reports
SCIENTIFIC REPORTS(6)
SCIENTIFIC REPORTS(6)
Metastatic breast cancers are aggressive tumors associated with high levels of epithelial-mesenchymal transition (EMT) markers, activation of IL6/JAK2/STAT3 and PI3K/AKT pathways for cell growth, mobility, invasion, metastasis, and CSC status. We ide
Autor:
Kande K. D. Amarasinghe, Sanjoy K. Chowdhury, Jeongbeob Seo, John Montgomery, Alexey V. Savchenko, Eric Oblinger
Publikováno v:
Pure and Applied Chemistry. 74:129-133
Substrates that possess an a,b-unsaturated carbonyl tethered to an alkyne have been utilized in a variety of nickel-catalyzed processes. Depending on ligand structure, reagent structure, reaction conditions, and workup conditions, several different m
Publikováno v:
The Journal of Organic Chemistry. 64:6060-6065
Unsaturated acyloxazolidinones and α‘-silyloxy enones were found to be effective substrates in nickel-catalyzed organozinc-promoted cyclizations. Both groups served as convenient enoate equivalents, whereas methyl enoates themselves were inefficie
Autor:
John Montgomery, Jeongbeob Seo
Publikováno v:
Tetrahedron. 54:1131-1144
A series of polyunsaturated enones were investigated in Ni(COD)2 / organozinc - mediated cyclizations. One substrate class underwent an efficient [2+2+2] cycloaddition reaction to generate a tricyclic ring system from a linear precursor. A discussion
Autor:
Hyun-Kyu, Park, Woori, Jo, Hyun-Ji, Choi, Bongcheol, Kim, Gilnam, Lee, Jeongbeob, Seo, Suk Young, Cho, Choung-Soo, Kim, Eun Kyung, Choi, Jung Jin, Hwang, Joo Yong, Lee, Young Hee, Yoon, Woo-Chan, Son
Publikováno v:
Journal of applied toxicology : JAT. 35(2)
Many systemic drugs can induce ocular toxicity and several ocular side-effects have been identified in clinical studies. However, it is difficult to detect ocular toxicity in preclinical studies because of the lack of appropriate evaluation methods.
Autor:
Suk Young Cho, Je-Hwan Lee, Gilnam Lee, Jung Jin Hwang, Choung-Soo Kim, Se Jin Jang, Jeongbeob Seo, Sang-wook Lee, Chulsoo Lim, Jene Choi, Ji-young Song
Publikováno v:
Investigational new drugs. 31(6)
Epidermal growth factor receptor (EGFR) gene mutations activate the KRAS-RAF-MEK-ERK pathway in lung cancer cells. EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib induce apoptosis of cancer cells, but prolonged treatment is often associated