Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jeong-Ho Oak"'
Autor:
Kiyotaka Nakagawa, Jeong-Ho Oak, Ohki Higuchi, Tsuyoshi Tsuzuki, Shinichi Oikawa, Haruhisa Otani, Masatoshi Mune, Hua Cai, Teruo Miyazawa
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2514-2524 (2005)
Peroxidized phospholipid-mediated cytotoxicity is involved in the pathophysiology of diseases [i.e., an abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) in plasma of type 2 diabetic patients]. The PCOOH accumulation may relate to Amador
Externí odkaz:
https://doaj.org/article/7f3a77deb0fe4ac08ebf4babcbf9195f
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 3, Pp 523-529 (2002)
Maillard reactions are among the most important of the chemical and oxidative changes occurring in food and biological samples that contribute to food deterioration and to the pathophysiology of human disease. Although the association of lipid glycat
Externí odkaz:
https://doaj.org/article/50b94927165a45b98ab519e95583394a
Autor:
Yuta Tanaka, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki
Publikováno v:
Journal of Medicinal Chemistry. 65:4270-4290
Inhibition of glucosylceramide synthase (GCS) is a major therapeutic strategy for Gaucher's disease and has been suggested as a potential target for treating Parkinson's disease. Herein, we report the discovery of novel brain-penetrant GCS inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a407ff68d50cb206d4c182ef36b2c1cf
https://doi.org/10.1021/acs.jmedchem.1c02078
https://doi.org/10.1021/acs.jmedchem.1c02078
Autor:
Hua Cai, Jeong-Ho Oak
Publikováno v:
Diabetes. 56:118-126
Angiotensin II (Ang II) levels are increased in patients with diabetes, but mechanisms underlying its contribution to diabetic vascular diseases are incompletely understood. We recently reported that in aortic endothelial cells, Ang II induces endoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee32b3e7070082904eaf327df8d941ce
https://doi.org/10.2337/db06-0288
https://doi.org/10.2337/db06-0288
Autor:
Tsuyoshi Tsuzuki, Teruo Miyazawa, Jeong Ho Oak, Haruhisa Otani, Hua Cai, Ohki Higuchi, Kiyotaka Nakagawa, Shinichi Oikawa, Masatoshi Mune
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 11, Pp 2514-2524 (2005)
Peroxidized phospholipid-mediated cytotoxicity is involved in the pathophysiology of diseases [i.e., an abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) in plasma of type 2 diabetic patients]. The PCOOH accumulation may relate to Amador
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c5612a876b005da976042a9f06e10b
https://doi.org/10.1194/jlr.d500025-jlr200
https://doi.org/10.1194/jlr.d500025-jlr200
Publikováno v:
Annals of the New York Academy of Sciences. 1043:280-283
Amadori-glycated phosphatidylethanolamine (Amadori-PE), a nonenzymatically glycated lipid formed under hyperglycemic conditions, is known as a reliable indicator of lipid glycation in vivo. We have quantified the Amadori-PE concentration in human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699a5b9162e7698d6e5f838545e3daa7
https://doi.org/10.1196/annals.1333.034
https://doi.org/10.1196/annals.1333.034
Publikováno v:
Annals of the New York Academy of Sciences. 1043:276-279
Phospholipid-linked glycation has been implicated to play an important role in lipid peroxidation associated with several conditions, such as normal aging and diabetes. In this study, we established a convenient method for the preparation of a high-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee59d50a22243b4d70e966260f0d28d
https://doi.org/10.1196/annals.1333.033
https://doi.org/10.1196/annals.1333.033
Publikováno v:
International Congress Series. 1245:285-288
The oxidative modification of lipids in food and biological systems has been recognized to play a central role in food deterioration and in pathophysiology of human diseases. Although the association of lipid glycation with this process has been rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd876eb91a5a14538c079328046cd06
https://doi.org/10.1016/s0531-5131(02)00911-1
https://doi.org/10.1016/s0531-5131(02)00911-1
Publikováno v:
International Congress Series. 1245:61-64
Using large unilamellar vesicles (LUVs), generally accepted to be a biomembrane model, we investigated the peroxidative role of the Amadori-product derived from the glycation of phosphatidylethanolamine (PE), namely Amadori-PE. Amadori-PE-LUV compose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ad7ff1bd8a60fbdf8489a5e13c8a11b
https://doi.org/10.1016/s0531-5131(02)01025-7
https://doi.org/10.1016/s0531-5131(02)01025-7
Publikováno v:
NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI. 49:646-651
本研究では,タマネギ抽出物がAmadori-PEの生成と細胞毒性に与える影響を調べDioleoyl PEとD-グルコースをメタノール中でインキュベート(60℃, 1日)すると,dioleoyl PEの50%がAmadori-PEに変換されて
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65badff9d90ab0769e1b51131272731b
https://doi.org/10.3136/nskkk.49.646
https://doi.org/10.3136/nskkk.49.646