Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jeong Su Do"'
Publikováno v:
Cells, Vol 13, Iss 11, p 891 (2024)
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of
Externí odkaz:
https://doaj.org/article/6d88eb26bd4948ef971f8340fd052cc0
Autor:
Jeong-su Do, Daniel Zwick, Jonathan D. Kenyon, Fei Zhong, David Askew, Alex Y. Huang, Wouter Van’t Hof, Marcie Finney, Mary J. Laughlin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The key obstacle to clinical application of human inducible regulatory T cells (iTreg) as an adoptive cell therapy in autoimmune disorders is loss of FOXP3 expression in an inflammatory milieu. Here we report human iTreg co-cultured with bon
Externí odkaz:
https://doaj.org/article/24468a2c65444254ba3db5b26d183319
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110516 (2014)
Naïve CD4 T cells are triggered to undergo spontaneous proliferation, a proliferative response induced in response to homeostatic stimulation, when exposed to severe lymphopenic environments. They spontaneously acquire proinflammatory effector pheno
Externí odkaz:
https://doaj.org/article/7cd3e9c00ac545ba84b0b36e45e055ec
Autor:
Mary J. Laughlin, Alex Yee-Chen Huang, Jeong-su Do, Marcie Finney, Daniel Zwick, Fei Zhong, Jonathan D. Kenyon, Wouter Van’t Hof, David Askew
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The key obstacle to clinical application of human inducible regulatory T cells (iTreg) as an adoptive cell therapy in autoimmune disorders is loss of FOXP3 expression in an inflammatory milieu. Here we report human iTreg co-cultured with bone marrow-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f696dcce0662d667736824a9cee71d3
http://europepmc.org/articles/PMC8140113
http://europepmc.org/articles/PMC8140113
Autor:
Wouter Van’t Hof, Fei Zhong, Mary J. Laughlin, Jeong su Do, Marcie Finney, Alex Yee-Chen Huang
Publikováno v:
Bone Marrow Transplantation. 53:1568-1577
Foxp3 is essential for T regulatory cell (Treg) function. Broad complex-Tramtrack-Bric-a-brac domain (BTB) and Cap'n'collar (CNC) homology 1, transcription factor 2 (BACH2) stabilizes Treg immune homeostasis in murine studies. However, little is know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d989cf9addf361a2a3f96ee7e0fe2084
https://doi.org/10.1038/s41409-018-0205-6
https://doi.org/10.1038/s41409-018-0205-6
Autor:
Emina Huang, Booki Min, Theresa T. Pizarro, Sohee Kim, Karen Keslar, Eun Jung Jang, Jeong Su Do, Robert L. Fairchild
Publikováno v:
The Journal of Immunology. 198:908-915
γδ T lymphocytes, dominant T cell subsets in the intestine, mediate both regulatory and pathogenic roles, yet the mechanisms underlying such opposing effects remain unclear. In this study, we identified a unique γδ T cell subset that coexpresses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b74097436db46023991d2f8d11bd96b
https://doi.org/10.4049/jimmunol.1601060
https://doi.org/10.4049/jimmunol.1601060
Autor:
Sohee Kim, Tara M. DeSilva, Eun Jung Jang, Nina Dvorina, Stephen A. Stohlman, Jeong-su Do, Xiaoxia Li, Vivekananthan Nagarajavel, Dario A. A. Vignali, Booki Min, Dongkyun Kim, Angela H. Ting, William M. Baldwin, Alice Valentin-Torres
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(38)
Dysregulated Foxp3+ Treg functions result in uncontrolled immune activation and autoimmunity. Therefore, identifying cellular factors modulating Treg functions is an area of great importance. Here, using Treg-specific Il27ra-/- mice, we report that I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77be62f99df63832013cfa75500fde12
https://pubmed.ncbi.nlm.nih.gov/28874534
https://pubmed.ncbi.nlm.nih.gov/28874534
Autor:
Michael L. Freeman, Jeong Su Do, Anabelle Visperas, Yoichiro Iwakura, Booki Min, Mohamed Oukka
Publikováno v:
Immunology and cell biology
Disturbance of T-cell homeostasis could lead to intestinal inflammation. Naive CD4 T cells undergoing spontaneous proliferation, a robust proliferative response that occurs under severe lymphopenic conditions, differentiate into effector cells produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b46808255690206163823edd3e8e8a2
https://doi.org/10.1038/icb.2013.70
https://doi.org/10.1038/icb.2013.70
Publikováno v:
Mucosal immunology
T helper type 17 (Th17) cells have been implicated in autoimmunity and inflammatory bowel disease (IBD). Antigen-presenting cell (APC) -derived cytokines such as interleukin (IL)-1β and IL-6 are key mediators supporting Th17 differentiation, yet how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c583ce66519b90ed9c4355f1e84c971
http://europepmc.org/articles/PMC3989480
http://europepmc.org/articles/PMC3989480
Autor:
Aoi Akitsu, Amy G. Hise, Edward S. Mocarski, Caroline El-Sanadi, Muhammet F. Gulen, Bradley N. Martin, Zizhen Kang, Xiaoxia Li, Paul L. Fox, Paul G. Pavicic, Marc E. Rothenberg, Yoichiro Iwakura, Booki Min, Anasuya Sarkar, Richard M. Ransohoff, Jarod A. Zepp, Guanglin Bian, Jeong Su Do, Junjie Zhao, Mark D. Wewers, Chenhui Wang, William J. Kaiser, George R. Dubyak, Cun Jin Zhang
Interleukin 1β (IL-1β) is critical for the in vivo survival, expansion and effector function of IL-17-producing helper T (T(H)17) cells during autoimmune responses, including experimental autoimmune encephalomyelitis (EAE). However, the spatiotempo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa7476c7d30f8272c4c361dd57654a7
https://europepmc.org/articles/PMC5385929/
https://europepmc.org/articles/PMC5385929/
