Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Jeong Seop, Rhee"'
Autor:
Nina Rößler, Tassilo Jungenitz, Albrecht Sigler, Alexander Bird, Martin Mittag, Jeong Seop Rhee, Thomas Deller, Hermann Cuntz, Nils Brose, Stephan W. Schwarzacher, Peter Jedlicka
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
Dendritic spines are crucial for excitatory synaptic transmission as the size of a spine head correlates with the strength of its synapse. The distribution of spine head sizes follows a lognormal-like distribution with more small spines than large on
Externí odkaz:
https://doaj.org/article/bd78c7109d364e9c9d436be340b75e5d
Autor:
Kyung Ah Han, Hee-Yoon Lee, Dongseok Lim, Jungsu Shin, Taek Han Yoon, Chooungku Lee, Jeong-Seop Rhee, Xinran Liu, Ji Won Um, Se-Young Choi, Jaewon Ko
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101203- (2020)
Summary: Leukocyte common antigen-related receptor tyrosine phosphatases (LAR-RPTPs) are evolutionarily conserved presynaptic organizers. The synaptic role of vertebrate LAR-RPTPs in vivo, however, remains unclear. In the current study, we analyzed t
Externí odkaz:
https://doaj.org/article/8331278c5a4e4d039059f9c23d3380dd
Autor:
Dennis B. Nestvogel, Ricardo Martins Merino, Carolina Leon-Pinzon, Manuel Schottdorf, ChoongKu Lee, Cordelia Imig, Nils Brose, Jeong-Seop Rhee
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3261-3269.e4 (2020)
Summary: Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control and sensory adaptation. Neurons employ synaptic vesicle priming proteins of
Externí odkaz:
https://doaj.org/article/5e7eccf9d8674c90a53cc788990e52c9
Autor:
Asha Kiran Akula, Xin Zhang, Julio S. Viotti, Dennis Nestvogel, Jeong-Seop Rhee, Rene Ebrecht, Kerstin Reim, Fred Wouters, Thomas Liepold, Olaf Jahn, Ivan Bogeski, Thomas Dresbach
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Neurotransmitter release is mediated by an evolutionarily conserved machinery. The synaptic vesicle (SV) associated protein Mover/TPRGL/SVAP30 does not occur in all species and all synapses. Little is known about its molecular properties and how it m
Externí odkaz:
https://doaj.org/article/bd88b6e42d3c4ddf8e9a60044d777648
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11268 (2021)
Ca2+ entry through Cav1.3 Ca2+ channels plays essential roles in diverse physiological events. We employed yeast-two-hybrid (Y2H) assays to mine novel proteins interacting with Cav1.3 and found Snapin2, a synaptic protein, as a partner interacting wi
Externí odkaz:
https://doaj.org/article/bae69d8ff4b841d7911c1fb77205dd9c
Autor:
Hong Jun Rhee, Ali H. Shaib, Kristina Rehbach, ChoongKu Lee, Peter Seif, Carolina Thomas, Erinn Gideons, Anja Guenther, Tamara Krutenko, Matthias Hebisch, Michael Peitz, Nils Brose, Oliver Brüstle, Jeong Seop Rhee
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2212-2228.e7 (2019)
Summary: iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized
Externí odkaz:
https://doaj.org/article/be79eb1df6054ca6a5dd84a11de59ece
Autor:
Lena S. Mortensen, Silvia J.H. Park, Jiang-bin Ke, Benjamin H. Cooper, Lei Zhang, Cordelia Imig, Siegrid Löwel, Kerstin Reim, Nils Brose, Jonathan B. Demb, Jeong-Seop Rhee, Joshua H. Singer
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2239-2250 (2016)
Complexin (Cplx) proteins modulate the core SNARE complex to regulate exocytosis. To understand the contributions of Cplx to signaling in a well-characterized neural circuit, we investigated how Cplx3, a retina-specific paralog, shapes transmission a
Externí odkaz:
https://doaj.org/article/3c96857817d840289321a4eb85904210
Autor:
Matthieu Hammer, Dilja Krueger-Burg, Liam Patrick Tuffy, Benjamin Hillman Cooper, Holger Taschenberger, Sarit Pati Goswami, Hannelore Ehrenreich, Peter Jonas, Frederique Varoqueaux, Jeong-Seop Rhee, Nils Brose
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 516-523 (2015)
Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are among the most common genetic abnormalities associated with autism spectrum disorders, but little is known about the function of Neuroligin-4 and the consequences of its los
Externí odkaz:
https://doaj.org/article/667388ddc3cc4c2a98b9a39a1297d127
Autor:
Olaf Jahn, Stefan Bonn, Klaus P. Hellmann, Nils Brose, Marilyn Tirard, Kamal Chowdhury, Jeong-Seop Rhee, Orr Shomroni, Silvia Ripamonti
Publikováno v:
Journal of neurochemistry 154(6), 647-661 (2020). doi:10.1111/jnc.15008
SUMOylation is a dynamic post-translational protein modification that primarily takes place in cell nuclei, where it plays a key role in multiple DNA-related processes. In neurons, the SUMOylation-dependent control of a subset of neuronal transcripti
Autor:
Rachel Straussberg, Marta Rosário, Guntram Borck, Victor Tarabykin, Olaf Jahn, Stephen Horan, A Ioana Weber, Rüstem Yilmaz, Ekrem Dere, Alina Smorodchenko, Hong Jun Rhee, Jeong-Seop Rhee, Susanne Mueller, Katrin I. Willig, Philipp Boehm-Sturm, Manuela Schwark, Mateusz C. Ambrozkiewicz, Sami Zaqout, Ekaterina Borisova, Theres Schaub, Bekir Altas, Silvia Ripamonti, Hiroshi Kawabe, Lars Piepkorn
Publikováno v:
Molecular Psychiatry. 26:1980-1995
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, encoding for a ubiquitin l