Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jeong Pil Han"'
Autor:
Jeong Hyeon Lee, Jeong Pil Han, Dong Woo Song, Geon Seong Lee, Beom Seok Choi, MinJeong Kim, Yeji Lee, Seokjoong Kim, Hyukjin Lee, Su Cheong Yeom
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 161-172 (2023)
Recent therapeutic strategies for hemophilia include long-term therapeutic gene expression using adeno-associated virus (AAV) and rebalancing therapy via the downregulation of anticoagulant pathways. However, these approaches have limitations in immu
Externí odkaz:
https://doaj.org/article/b2eacd899eaa49578e6f6dbdd78f0144
Autor:
Jeong Pil Han, Yeji Lee, Jeong Hyeon Lee, Hye Yoon Chung, Geon Seong Lee, Yu Ri Nam, Myeongjin Choi, Kyoung-Sik Moon, Haeshin Lee, Hyukjin Lee, Su Cheong Yeom
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102050- (2023)
Gene therapy and rebalancing therapy have emerged as promising approaches for treating hemophilia A, but there are limitations, such as temporary efficacy due to individual differences. Genome editing for hemophilia has shown long-term therapeutic po
Externí odkaz:
https://doaj.org/article/04122e44a72248089f84d8113f0cc24e
Autor:
Jeong Hyeon Lee, Hye-Kyung Oh, Beom Seok Choi, Ho Hyeon Lee, Kyu Jun Lee, Un Gi Kim, Jina Lee, Hyerim Lee, Geon Seong Lee, Se Jun Ahn, Jeong Pil Han, Seokjoong Kim, Su Cheong Yeom, Dong Woo Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 551-562 (2022)
Recently, clinical trials of adeno-associated virus-mediated replacement therapy have suggested long-term therapeutic effects for several genetic diseases of the liver, including hemophilia. However, there remain concerns regarding decreased therapeu
Externí odkaz:
https://doaj.org/article/6ce05ab8d5ed4e9389d35cc55017b674
Autor:
Geon Seong Lee, Geon Kwak, Ji Hyun Bae, Jeong Pil Han, Soo Hyun Nam, Jeong Hyeon Lee, Sumin Song, Gap-Don Kim, Tae Sub Park, Yang Kyu Choi, Byung-Ok Choi, Su Cheong Yeom
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
The microrchidia (MORC)-family CW-type zinc finger 2 (MORC2) gene is related to DNA repair, adipogenesis and epigenetic silencing via the human silencing hub (HUSH) complex. MORC2 missense mutation is known to cause peripheral neuropathy of Charcot-M
Externí odkaz:
https://doaj.org/article/ff35c3cd53c74585a5924306be1525fd
Publikováno v:
Biology, Vol 10, Iss 8, p 704 (2021)
Hemophilia A (HA) is an X-linked recessive blood coagulation disorder, and approximately 50% of severe HA patients are caused by F8 intron 22 inversion (F8I22I). However, the F8I22I mouse model has not been developed despite being a necessary model t
Externí odkaz:
https://doaj.org/article/bbb4651267f34ac191108d375e067ca4
Publikováno v:
Cells, Vol 10, Iss 5, p 1028 (2021)
Neuronal nitric oxide synthase (nNOS) has various roles as a neurotransmitter. However, studies to date have produced insufficient data to fully support the correlation between nNOS and bowel motility. This study aimed to investigate the correlation
Externí odkaz:
https://doaj.org/article/1edad3b2311b440e91960584027c6e18
Autor:
Jeong Pil Han, Yoo Jin Chang, Dong Woo Song, Beom Seok Choi, Ok Jae Koo, Seung Youn Yi, Tae Sub Park, Su Cheong Yeom
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3747 (2020)
In homology-directed repair, mediated knock-in single-stranded oligodeoxynucleotides (ssODNs) can be used as a homologous template and present high efficiency, but there is still a need to improve efficiency. Previous studies have mainly focused on c
Externí odkaz:
https://doaj.org/article/52a9fea8b312467786e900017e22a5f3
Autor:
Sungsook Yu, Su Cheong Yeom, Tae Wook Nam, Ki Taek Nam, Young Jin, Jae-Hoon Lee, Ji-Young Cha, Yoon Ki Kim, Jeong Pil Han, Jae Il Roh, Han Woong Lee
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Engineered nucleases are widely used for creating frameshift or nonsense mutations in the target genes to eliminate gene functions. The resulting mRNAs carrying premature termination codons can be eliminated by nonsense-mediated mRNA decay. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058f546159429bd9fd972b090da44352
http://link.springer.com/article/10.1038/s41598-020-61154-4
http://link.springer.com/article/10.1038/s41598-020-61154-4
Autor:
Jeong Pil Han, MinJeong Kim, Beom Seok Choi, Jeong Hyeon Lee, Geon Seong Lee, Michaela Jeong, Yeji Lee, Eun-Ah Kim, Hye-Kyung Oh, Nanyeong Go, Hyerim Lee, Kyu Jun Lee, Un Gi Kim, Jae Young Lee, Seokjoong Kim, Jun Chang, Hyukjin Lee, Dong Woo Song, Su Cheong Yeom
Publikováno v:
Science Advances
Hemophilia is a hereditary disease that remains incurable. Although innovative treatments such as gene therapy or bispecific antibody therapy have been introduced, substantial unmet needs still exist with respect to achieving long-lasting therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb04fe64af157d8ac2d76b9a60792218
http://europepmc.org/articles/PMC8782450
http://europepmc.org/articles/PMC8782450
Autor:
Ji Hyun Bae, Sumin Song, Geon Kwak, Soo Hyun Nam, Byung-Ok Choi, Jeong Pil Han, Gap-Don Kim, Jeong Hyeon Lee, Su Cheong Yeom, Yang-Kyu Choi, Tae Sub Park, Geon Seong Lee
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 10 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
The microrchidia (MORC)-family CW-type zinc finger 2 (MORC2) gene is related to DNA repair, adipogenesis and epigenetic silencing via the human silencing hub (HUSH) complex. MORC2 missense mutation is known to cause peripheral neuropathy of Charcot-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ead6c6cf23f49d6edd3b538cb835ca3
https://doi.org/10.1242/dmm.049123
https://doi.org/10.1242/dmm.049123